Vitamin C deficiency

Vitamin C deficiency is a systemic nutritional disorder caused by an inadequate intake or impaired absorption of ascorbic acid, an essential water-soluble micronutrient and antioxidant Because ascorbic acid serves as an obligate cofactor for prolyl and lysyl hydroxylases, its depletion impairs collagen synthesis and destabilizes connective tissues throughout the integumentary, musculoskeletal, and vascular systems Severe deficiency progresses to scurvy, which is clinically characterized by capil...

Vitamin C deficiency is a systemic nutritional disorder caused by an inadequate intake or impaired absorption of ascorbic acid, an essential water-soluble micronutrient and antioxidant Because ascorbic acid serves as an obligate cofactor for prolyl and lysyl hydroxylases, its depletion impairs collagen synthesis and destabilizes connective tissues throughout the integumentary, musculoskeletal, and vascular systems Severe deficiency progresses to scurvy, which is clinically characterized by capil...

Because ascorbic acid serves as an obligate cofactor for prolyl and lysyl hydroxylases, its depletion impairs collagen synthesis and destabilizes connective tissues throughout the integumentary, musculoskeletal, and vascular systems

Severe deficiency progresses to scurvy, which is clinically characterized by capillary fragility, perifollicular petechiae, ecchymoses, corkscrew hairs, swollen or bleeding gums, poor wound healing, and arthralgias

It primarily affects malnourished populations, individuals with chronic alcohol use disorder, patients with severe malabsorptive gastrointestinal conditions, and those with highly restricted dietary regimens

It primarily affects malnourished populations, individuals with chronic alcohol use disorder, patients with severe malabsorptive gastrointestinal conditions, and those with highly restricted dietary regimens

It primarily affects malnourished populations, individuals with chronic alcohol use disorder, patients with severe malabsorptive gastrointestinal conditions, and those with highly restricted dietary regimens