Wernicke-Korsakoff syndrome

Wernicke-Korsakoff syndrome is a dual-phase neurocognitive disorder of the central nervous system caused by severe thiamine (vitamin B1) deficiency, most frequently affecting adults with chronic alcohol use disorder or severe malnutrition It manifests initially as Wernicke encephalopathy, an acute, life-threatening syndrome characterized by altered mental status, ocular motor disturbances such as nystagmus or ophthalmoplegia, and gait ataxia If untreated or inadequately managed, it can progress ...

Wernicke-Korsakoff syndrome is a dual-phase neurocognitive disorder of the central nervous system caused by severe thiamine (vitamin B1) deficiency, most frequently affecting adults with chronic alcohol use disorder or severe malnutrition If untreated or inadequately managed, it can progress to Korsakoff syndrome, a chronic neuropsychiatric state characterized by profound anterograde and retrograde amnesia, executive dysfunction, and confabulation

Wernicke-Korsakoff syndrome is a dual-phase neurocognitive disorder of the central nervous system caused by severe thiamine (vitamin B1) deficiency, most frequently affecting adults with chronic alcohol use disorder or severe malnutrition

Wernicke-Korsakoff syndrome is a dual-phase neurocognitive disorder of the central nervous system caused by severe thiamine (vitamin B1) deficiency, most frequently affecting adults with chronic alcohol use disorder or severe malnutrition

Pathophysiologically, depleted thiamine impairs cerebral glucose metabolism and leads to neuronal injury in vulnerable diencephalic and brainstem structures, including the mammillary bodies, thalamus, and periaqueductal gray It manifests initially as Wernicke encephalopathy, an acute, life-threatening syndrome characterized by altered mental status, ocular motor disturbances such as nystagmus or ophthalmoplegia, and gait ataxia

Pathophysiologically, depleted thiamine impairs cerebral glucose metabolism and leads to neuronal injury in vulnerable diencephalic and brainstem structures, including the mammillary bodies, thalamus, and periaqueductal gray If untreated or inadequately managed, it can progress to Korsakoff syndrome, a chronic neuropsychiatric state characterized by profound anterograde and retrograde amnesia, executive dysfunction, and confabulation