Zollinger-Ellison syndrome

Zollinger-Ellison syndrome is a rare neuroendocrine disorder characterized by the development of gastrin-secreting tumors, known as gastrinomas, which predominantly arise within the duodenum or pancreas Zollinger-Ellison syndrome most frequently occurs sporadically, though roughly 20% to 25% of cases arise in association with the inherited autosomal dominant disorder multiple endocrine neoplasia type 1

Zollinger-Ellison syndrome is a rare neuroendocrine disorder characterized by the development of gastrin-secreting tumors, known as gastrinomas, which predominantly arise within the duodenum or pancreas These functional neoplasms autonomously produce excessive amounts of gastrin, stimulating gastric parietal cells to induce profound, uncontrolled gastric acid hypersecretion Pathophysiologically affecting the gastrointestinal tract, the resulting hyperchlorhydria commonly presents with severe, re...

Pathophysiologically affecting the gastrointestinal tract, the resulting hyperchlorhydria commonly presents with severe, recurrent, or refractory peptic ulcer disease, gastroesophageal reflux, abdominal pain, and secretory diarrhea