Clinical intelligence & editorial.

PubMed

Real-world Evaluation of Intravenous Amisulpride in Postoperative Nausea and Vomiting Prevention in India.

Abstract Background The efficacy and safety of intravenous amisulpride in the prevention of postoperative nausea and vomiting (PONV) is established in adult surgical patients; however, evidence in the Indian population is lacking. The phase IV, multicenter, single-arm clinical trial evaluated the efficacy and safety of intravenous amisulpride in preventing PONV in Indian adults undergoing surgery. Materials and methods Adult patients undergoing elective surgery during general anesthesia with...

Nausea And Vomiting

Shah HJ, Pariyani J, Shinde KV, Tamma R, Matey VK, Sharma PK, Kunal GS, Singh VR, Bunkar SK, Agrawal KK, Ramesh G• January 16, 2026

PubMed

Application of artificial intelligence in diagnosis and management of fetal growth disorders: a comprehensive review.

Fetal growth disorders, including both fetal growth restriction and macrosomia, remain major contributors to perinatal morbidity and long-term health risks in adulthood. While ultrasound is the most frequently employed technique for the diagnosis of intrauterine growth abnormalities, its efficacy is constrained by the operator’s experience and variable accuracy. This review explores the role of artificial intelligence (AI) in advancing the detection and management of fetal growth disorders. We c...

Growth Disorders

Ługowski F, Babińska J, Stanirowski PJ• January 16, 2026

PubMed

The imbalance of Th17/Treg cells exists in asymptomatic hyperuricemia (the early stage of gout).

Objectives Given that hyperuricemia is a metabolic condition with a prolonged asymptomatic period and strong associations with gout and various metabolic disorders, we investigated the role of lymphocyte subsets in asymptomatic hyperuricemia (aHUA) and explored their potential implications for immune regulation. Method The study enrolled 59 male patients with aHUA, 29 with acute gout (AG), and 28 healthy male controls (HCs). Laboratory data, including blood cell counts, inflammatory markers,...

Gout And Hyperuricemia

Zhang LQ, Zhao LJ, Qin AL, Wen QY, Gao C, Li XF• January 16, 2026

CDC

Hypertension in Pregnancy Change Package

The Hypertension in Pregnancy Change Package lists process improvements to help clinicians provide care to pregnant women and women of reproductive age.

Hypertension

January 15, 2026

PLOS

Impact of COVID-19 restrictions on thyroid cancer diagnoses in a comprehensive cancer center (2017–2023)

Introduction: The Coronavirus 2019 (COVID-19) pandemic disrupted healthcare delivery across the United States, leading to a sharp decline in outpatient visits. Given that thyroid nodule evaluation and diagnosis typically occur in outpatient settings, we hypothesized that these disruptions would reduce thyroid cancer incidence. This study evaluates trends in thyroid cancer diagnosis, treatment, and outcomes at a U.S. comprehensive cancer center from 2017 to 2023. Methods: We included adults with...

Thyroiditis

Hayley Mann, Erin Dimon, Yichi Zhang, Natalia Arroyo, Abdullah Adil, Yanchen Zhang, Oguzhan Alagoz, Sara Fernandes-Taylor, Erin J. Aiello Bowles, Louise Davies, David O. Francis• January 15, 2026

PLOS

Prevalence of hypertension and associated factors among nurses working in private and public tertiary hospitals in Dar Es Salaam, Tanzania

Nurses face numerous occupational stressors associated with an increased risk of hypertension. This study aimed to determine the prevalence of hypertension and its associated factors among nurses in private and public tertiary hospitals in Dar es Salaam, Tanzania. A cross-sectional study was conducted between July and November 2023 among nurses from one private and one public tertiary hospital. All eligible nurses in the private hospital were recruited, while stratified random sampling was used...

Hypertension

Jestina M. Rutagengwa, Theresia A. Ottaru, Ezra J. Mrema, Zuhura I. Kimera, Hussein H. Mwanga• January 15, 2026

PubMed

Re-ascent triggered high-altitude pulmonary and cerebral edema in a Tibetan with pre-existing high-altitude polycythemia: a Case Report.

High-altitude pulmonary edema (HAPE), high-altitude cerebral edema (HACE), and high-altitude polycythemia (HAPC) are each rarely observed in Tibetan populations. The coexistence of HAPE, HACE, and HAPC in the same person has not been previously documented. Here, we report the case of a native Tibetan male with HAPC who developed both HAPE and HACE upon re-ascent to an altitude of 3,650 m after a 27-day stay at low altitude. On the 3rd-4th day post-return, the patient exhibited persistent dyspnea...

Cerebral Edema

Huang H, Yuan S, Zhang L, Song J, Xue D, Liu D, Cao J• January 15, 2026

PubMed

Chronic HIV infection complicated by pancreatitis, pancreatic tail pseudocyst and atraumatic splenic rupture: a case report.

Background Acute pancreatitis is an uncommon but clinically important complication in people living with HIV (PLWH) and has been linked to HIV itself, older nucleoside reverse transcriptase inhibitors, protease inhibitors via hypertriglyceridemia, and multiple opportunistic or metabolic comorbidities. Atraumatic splenic rupture (ASR) is rare and has been described in association with acute or chronic pancreatitis and, more rarely, with HIV infection. However, the coexistence of chronic HIV infe...

Hiv Infection

Luo C, Lu Z, Liang J, Lu T, Gao M, He T• January 15, 2026

PubMed

A Single-Center Profile of Pemphigus in China: Significant Diagnostic Delay and Evolving Treatment Patterns.

Purpose Pemphigus encompasses a group of rare and potentially life-threatening autoimmune bullous diseases. Epidemiological research on pemphigus in China remains limited. This study aimed to analyze the clinical characteristics, diagnostic delay, and initial treatment patterns of patients with newly diagnosed pemphigus at a tertiary center in China. Patients and Methods This retrospective study included patients newly diagnosed with pemphigus between January 2020 and December 2024 at the out...

Pemphigus

Zhang H, Li D, Zhang Y, Lu X, Tang K, Zuo YG, Jin H• January 15, 2026

PubMed

Diffuse Large B-cell Lymphoma Presenting with Protein-losing Enteropathy during Treatment for Systemic Lupus Erythematosus.

Protein-losing enteropathy (PLE) is a rare complication of systemic lupus erythematosus (SLE). A 38-year-old woman with well-controlled SLE developed abdominal pain, lower-extremity edema, anemia, and hypoalbuminemia. The patient was then diagnosed with PLE. Despite treatment with glucocorticoids and cyclophosphamide, persistent hypoalbuminemia was observed. A biopsy was performed using double-balloon enteroscopy due to small bowel lesions, which confirmed the diagnosis of diffuse large B-cell l...

Systemic Lupus Erythematosus

Yasui S, Nishimura K, Tanimoto Y, Mugitani M, Sugano T, Sy-Janairo ML, Watanabe D, Sakai R, Yamada H, Saegusa J• January 15, 2026

PubMed

Adult-Onset Hypopigmented Mycosis Fungoides: A Systematic Review of Clinicopathologic, Immunophenotypic, and Therapeutic Characteristics.

Abstract Background/Objectives: Hypopigmented mycosis fungoides (hMF) is a rare variant of mycosis fungoides (MF) often seen in younger patients and individuals with darker skin phototypes. The lesions develop as hypopigmented patches or plaques, and they are usually asymptomatic and respond well to topical treatment or phototherapy. Methods: We provide a systematic review on hMF with onset at or beyond 30 years of age, based on SCOPUS, PubMed, and Embase databases. A total of 13 original artic...

Mycosis Fungoides

Kimak-Pielas A, Robak E, Robak T, Żebrowska A• January 15, 2026

PubMed

Cytomegalovirus Colitis during Budesonide Therapy for Ulcerative Colitis.

Budesonide is recommended for mild-to-moderate ulcerative colitis (UC); however, cytomegalovirus (CMV) colitis may still emerge during therapy. We report the case of a 69-year-old woman with left-sided UC who developed worsening diarrhea and hematochezia while receiving budesonide rectal foam and MMX. Colonoscopy revealed longitudinal, undermined, and “double-tracked” ulcers in the rectosigmoid. CMV pp65 antigenemia was positive, and immunohistochemical staining of a biopsy specimen revealed CMV...

Ulcerative Colitis

Tamazawa K, Aizawa M, Wada J, Ishizaki N, Suzuki K, Otomo K, Takagi T, Togashi K, Ohira H• January 15, 2026