Sign in Register

Clinical intelligence & editorial.

Advertisement

Advertisement

Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,597–1,608 of 2,098 articles

PubMed

When Warm Meets Cold: Mixed-Type Autoimmune Hemolytic Anemia Revealing an Underlying Autoimmune Disorder.

Autoimmune hemolytic anemia (AIHA) is a rare immune-mediated disorder caused by autoantibodies directed against red blood cell antigens. Mixed-type AIHA, characterized by the coexistence of warm-reactive IgG and cold-reactive complement-fixing antibodies, is uncommon and often diagnostically challenging due to overlapping serologic features and transfusion incompatibility. We report the case of a 40-year-old woman who presented with an acute onset of breathlessness, palpitations, and severe fati...

Articles
S M, Jain D, Ramachandran K•
PubMed

Association between anti-TNF and NSAID therapy and choroidal and macular thickness in ankylosing spondylitis: an OCT-based study.

This prospective, cross-sectional study aimed to evaluate the association between non-steroidal anti-inflammatory drugs (NSAIDs) and anti–tumor necrosis factor-α (anti-TNF-α) therapy and retinal and choroidal thickness in patients with ankylosing spondylitis (AS) without uveitis, and to compare these findings with healthy controls. A total of 65 AS patients and 30 age- and sex-matched healthy controls were included. Macular thickness, retinal nerve fiber layer (RNFL) thickness, and subfoveal cho...

Articles
Gök ZE, Altuner MŞ, Mutlu K•
PubMed

Identification and validation of PANoptosis-related genes in ankylosing spondylitis.

Ankylosing spondylitis (AS) is a common immune inflammatory disease. PANoptosis, as a novel programmed cell death pathway, its mechanism of action in ankylosing spondylitis remains unclear. Therefore, this study aims to clarify the role of a novel programmed cell death pattern - PANoptosis - in the pathogenesis of ankylosing spondylitis (AS), and to screen and verify key genes (APRGS), providing new ideas for the diagnosis and treatment of AS. Based on multiple gene expression datasets (GSE25101...

Articles
Shan Z, Li J, Mu X, Zhang J, Ren S•
PubMed

Evaluating Associations Between Ankylosing Spondylitis, Torque Teno Virus and Polymorphisms in Interleukin 6 and Vitamin D Receptor Genes.

ABSTRACT The etiology of ankylosing spondylitis (AS) is complex and not yet fully understood. Interleukin‐6 (IL‐6), vitamin D and the vitamin D receptor (VDR) play an important role in modulating immune response, and Torque teno virus is considered a marker of immune status. This case–control study aimed to investigate the predisposition to AS. A total of 85 patients with AS and 100 clinically healthy individuals were included. VDR polymorphisms (rs2228570, rs1544410, rs7975232, rs731236) were...

Articles
Cimponeriu D, Berca LM, Radu I, Toma M, Nica R, Nica S, Măciucă R•
PubMed

Lisinopril-Induced Angioedema Triggered by Tattoo Cellulitis and Acute Kidney Injury: A Case Report.

Angiotensin-converting enzyme inhibitor-induced angioedema is a rare, potentially life-threatening disorder. This mostly manifests with swelling of the lips, tongue, and face with no known reports of angiotensin-converting enzyme inhibitor-induced angioedema from soft-tissue infections. We present herein a case of a 47-year-old male with a history of chronic kidney disease stage III who developed acute upper lip angioedema and severe acute kidney injury while on lisinopril/hydrochlorothiazide, f...

Articles
Zedan M, Howard S, Foryt P, Aroriode T•
PubMed

Case series of selenium insufficiency among infants with intestinal failure.

Background Selenium (Se) is an essential trace element incorporated into ‘selenoenzymes’ that are necessary for immune, thyroid and antioxidant responses. Infants with intestinal failure (IF) require prolonged administration of parenteral nutrition (PN). This report presents a series of infants with IF who demonstrate biochemical Se deficiency despite PN supplementation, which normalized following dose escalation. Case Series Patient 1 was born at 25 weeks’ gestation, birthweight 870 g, with...

Articles
Bodkin D, Hemani A, Miller J, Fraysur J, Fuchs E•
PubMed

Swimming in the Air: The Power of Drag at Miniature Scales.

Synopsis At the very edge of powered flight exist miniature insects with typical characteristic wing lengths of less than 1 mm. At such small scales, this domain of flight is characterized by Reynolds numbers (\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{upgreek} \usepackage{mathrsfs} \setlength{\oddsidemargin}{-69pt} \begin{document} $Re$\end{document}) of the order of 10 or less where the eff...

Articles
Sidebottom M, Margetts L, Nabawy MRA•
PubMed

Synthesizing Sex/es Across Scales and Lineages: Centering Plants, Algae, Fungi, Protists, and Modular Metazoans.

Synopsis As humans, we bring biases based on our own vertebrate, mammalian biology into the way we conceptualize the world. This includes how we discuss the range of concepts we reference with the term sex and the implicit assumptions that are often embedded in how we discuss life cycles and reproduction. These assumptions situate diplontic life cycles, unitary body plans, and amphigonic reproduction as normative and frame sex (meiosis and syngamy) and reproduction (the creation of new individu...

Articles
Casper AMA, Warkentin KM•
PubMed

Synthesis of Csp (3) Chlorinated Compounds from Cyclopropanes, Olefins, and C-H Bonds via Photolysis of Willgerodt-Type Reagents.

Csp3–Cl bonds are essential as diversification handles in organic synthesis and are found in many natural products and bioactive molecules. In this work, we introduce a general protocol for the selective chlorination of aryl cyclopropanes, olefins, and activated C–H bonds using direct photoexcitation of Willgerodt-type reagents to generate chlorine radicals. Preliminary results for an iodine­(I/III) catalytic process starting from abundant chloride salts are also presented. Furthermore, a one-po...

Articles
Nguyen TVT, Nguyen TVQ, Tran TTH, Nguyen QH, Waser J•
PubMed

Digital Tools and Chrononutrition: The Role of Wearables, Continuous Glucose Monitoring, and Apps.

Digital chrononutrition integrates wearable sensors, continuous glucose monitoring (CGM), and smart mobile applications to enable precision-based meal timing tailored to each individual’s circadian and metabolic patterns. Wearables track biological rhythms, such as sleep cycles, heart rate variability, and body temperature to define optimal meal windows. CGMs capture detailed glucose profiles, highlighting how meals consumed at different times affect postprandial glycemic responses. When these d...

Articles
Kumar S, Kumari A, Kumar D, Mondal H•
PubMed

[Research in university ENT departments-results of a Germany-wide survey on motivation, barriers, and structural conditions].

Hintergrund Forschung ist ein zentraler Bestandteil der universitären Hals-Nasen-Ohren‑/HNO-Heilkunde. Gleichzeitig stehen klinisch tätige Ärztinnen und Ärzte unter zunehmendem Druck, wissenschaftliche Tätigkeiten mit steigenden Anforderungen im Klinikalltag zu vereinbaren. Ziel der Arbeit Ziel der Studie war es, Motivation, Hemmnisse und strukturelle Rahmenbedingungen für Forschung und wissenschaftliche Qualifikation an deutschen HNO-Universitätsklinika zu analysieren und praxisnahe Empfehlu...

Articles
Kürten CHL, Boosfeld L, Holtmann L, Hansen S, Daser A, Stähr K, Mattheis S, Deitmer T, Stöver T, Hoffmann TK, Lang S•
PubMed

Complex relationship among vessel diameter, shear stress and blood pressure controlling vessel pruning during angiogenesis.

Blood vessel pruning during angiogenesis is the optimization process of the branching pattern to improve the transport properties of a vascular network. Recent studies show that part of endothelial cells (ECs) subjected to lower shear stress migrate toward vessels with higher shear stress in opposition to the blood flow for vessel regression. While dynamic changes of blood flow and local mechano-stress could coordinately modulate EC migration for vessel regression within the closed circulatory s...

Articles
Kumar V, Kumar P, Hikita T, Ding M, Kametani Y, Nakayama M, Hasegawa Y•