Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Attention Deficit Hyperactivity Disorder (ADHD)* Data are for the U.S. Morbidity: Children ages 3–17 years Percent ever diagnosed with ADHD: 12.0% (2024) Percent of boys ever diagnosed with ADHD: 15.6% (2024) Percent of girls ever diagnosed with ADHD: 8.2% (2024) Source: Interactive Summary Health Statistics for Children: National Health Interview Survey, 2019-2024 Health center visits Rate of visits to health centers by adults with attention deficit/hyperactivity disorder: 52.6 visits/10,...
Background: Klebsiella pneumoniae causes ~20% of sepsis in neonates, with ~40% crude mortality. A vaccine administered to pregnant women, protecting against ≥70% of K. pneumoniae infections, could avert ~400,000 cases and ~80,000 deaths annually, mostly in Africa and South Asia. Vaccine formulations targeting the capsular polysaccharide (K) or lipopolysaccharide (O) antigens are in development. Global K. pneumoniae populations display extensive K and O diversity, necessitating a polyvalent vacci...
Articles
Thomas D. Stanton, Shaun P. Keegan, Jabir A. Abdulahi, Anne V. Amulele, Matthew Bates, Eva Heinz, Yogesh Hooda, Weiming Hu, Kajal Jain, Samiah Kanwar, Rindidzani Magobo, Courtney P. Olwagen, John M. Tembo, Tolbert Sonda, Jonathan Strysko, Caroline C. Tigoi, Sameen Ahmad Amin, Kyle Bittinger, Jennifer Cornick, Ebenezer Foster-Nyarko, Wilson Gumbi, Aneeta Hotwani, Naveed Iqbal, Steven M. Jones, Furqan Kabir, Waqasuddin Khan, Chileshe L. Musyani, Carolyn M. McGann, Varsha Mittal, Ahmed M. Moustafa, Patrick Musicha, James C.L. Mwansa, Moreka L. Ndumba, Erkison E. Odih, Donwilliams O. Omuoyo, Oliver Pearse, Laura T. Phillips, Paul J. Planet, Aniqa Abdul Rasool, Charlene M. C. Rodrigues, Kirsty Sands, Arif M. Tanmoy, Erin Theiller, Allan M. Zuza, Sulagna Basu, Grace J. Chan, Kenneth C. Iregbu, Jean-Baptiste Mazarati, Semaria Solomon Alemayehu, Timothy R. Walsh, Rabaab Zahra, Angela Dramowski, Sombo Fwoloshi, Appiah-Korang Labi, Lola Madrid, Noah Obeng-Nkrumah, David Ojok, Boaz D. Wadugu, Andrew C. Whitelaw, Adhisivam Bethou, Anudita Bhargava, Atul Jindal, Ruchi N. Nanavati, Priyanka S. Prasad, Apurba Sastry, Joveria Q. Farooqi, Najia Ghanchi, Fyezah Jehan, Erum Khan, Ramesh K. Agarwal, Alexander M. Aiken, James A. Berkley, Susan E. Coffin, Nicholas A. Feasey, Nelesh P. Govender, Davidson H. Hamer, Shabir A. Madhi, Muhammad Imran Nisar, Samir K. Saha, Senjuti Saha, Mari Jeeva Sankar, Kelly L. Wyres, Kathryn E. Holt•
Schizophrenia frequently involves comorbid substance use, exacerbating symptoms and reducing treatment efficacy yet no prior studies have examined this comorbidity locally. This study determined the prevalence and factors associated with illicit substance use among adults with schizophrenia at the Livingstone University Teaching Hospital (LUTH). A hospital-based single center cross-sectional study was conducted at LUTH from January to June 2023. A sample of 303 adults with schizophrenia were rec...
Articles
Kimberley R. Kurehwatira, Emmanuel L. Luwaya, Joreen P. Povia, Chileleko Siakabanze, Salma M. Baines, Emmanuel Yumba, Prince Mulambo, David N. Masta, Nestorine N. Ngongo, Natasha Chishala, Emmanuel O. Riwo, Katongo H. Mutengo, Hanzooma Hatwiko, Martin Chakulya, Lukundo Siame, Bislom C. Mweene, Sepiso K. Masenga•
Isothermal nucleic acid amplification methods, such as recombinase polymerase amplification (RPA), are becoming increasingly vital as diagnostic platforms for neglected tropical diseases by enabling rapid and accurate detection in under-resourced regions. We developed a real-time RT-RPA assay for Machupo virus (MACV), the causative agent of Bolivian hemorrhagic fever, and directly compared it to a real-time RT-PCR assay targeting the same viral sequence fragment. The methods were evaluated acros...
Articles
Marina A. Kapitonova, Anna V. Shabalina, Igor S. Sukhikh, Artemiy A. Volkov, Vladimir G. Dedkov, Anna S. Dolgova•
Influenza is primarily a respiratory disease but can cause a broad spectrum of complications, including those affecting the cerebrovascular system. The aim of this study was to evaluate cerebrovascular reactivity in patients during and after influenza infection. A total of 92 participants, mean age 43 years, were enrolled; 46 patients with confirmed influenza infection and 46 healthy controls. Cerebrovascular reactivity was assessed using transcranial Doppler in combination with the breath-holdi...
Articles
Ana Orsolic Beslic, Kresimir Caljkusic, Antonela Matana, Katarina Tomelic Ercegovic, Mirela Pavicic Ivelja•
Blood vessel pruning during angiogenesis is the optimization process of the branching pattern to improve the transport properties of a vascular network. Recent studies show that part of endothelial cells (ECs) subjected to lower shear stress migrate toward vessels with higher shear stress in opposition to the blood flow for vessel regression. While dynamic changes of blood flow and local mechano-stress could coordinately modulate EC migration for vessel regression within the closed circulatory s...
Fragile X Syndrome (FXS) is a genetic disorder caused by increased CGG repeats in the Fragile X Messenger Ribonucleoprotein 1 (FMR1) gene which encodes an RNA-binding protein that can alter mRNA processing, translation and stability. Among the effects of FMRP deficiency is the modulation of metabolic pathway gene expression resulting in reduced cholesterol. In this report, the role of Fmr1 in modulating serum cholesterol of mice fed Western diet was investigated. Fmr1-KO mice had reduced serum c...
Articles
Xiaoning Zhao, Jianchang Zhou, Kuang-Yuh Chyu, Ebru Erbay, Bojan Cercek, Prediman K. Shah, Paul C. Dimayuga•
The recent death of many children linked to cough syrup has raised many questions on Indian drug manufacturing quality and its regulation. As WHO linked the death to the poor standard of the drug, it poses a serious question on the prevalent practice of manufacturing and quality control in the country. Moreover, as the deaths were for treatment of a mild symptom, it raises many questions such as why this happened, that is, whether there was any contamination to the formulation? Was there any iss...
Objective A longer duration of untreated illness (DUI) has been associated with poorer outcomes across several mental disorders; however, few studies have investigated DUI in anxiety disorders, particularly in generalized anxiety disorder (GAD). This study aimed to identify sociodemographic and clinical factors associated with a longer DUI in GAD. Methods We conducted a cross-sectional, multicenter study, retrospectively reviewing the medical records of GAD patients from three mental health s...
Articles
Affaticati LM, Giglio E, Capuzzi E, Riva I, La Tegola D, Colmegna F, Clerici M, Buoli M•
Introduction The incidence of infusion-related reactions (IRRs) caused by rituximab is very high, and many studies have explored factors related to the onset of IRR; however, most analyses have been conducted on a mixed range of disease indications. This study aimed to investigate rituximab-induced IRR in patients with non-Hodgkin lymphoma (NHL), particularly follicular lymphoma (FL), and examine the factors related to its occurrence. Methods Data on sociodemographic and blood test findings w...
Articles
Hirobe S, Fukada K, Miyamoto M, Inukai M, Fujimoto R, Maeda S, Maeda M, Fujio Y•
Background JO40295 (jRCT2080223801) evaluated the efficacy and safety of subcutaneous (SC) mosunetuzumab, in combination with lenalidomide and as monotherapy, in Japanese patients with relapsed/refractory (R/R) follicular lymphoma (FL). We report outcomes from the interim analysis of the FLMOON-2 (≥ 1 prior therapy; mosunetuzumab plus lenalidomide) and primary analysis of the FLMOON-3 (≥ 2 prior therapies; mosunetuzumab monotherapy) cohorts. Methods Mosunetuzumab SC was administered with Cycl...
Articles
Makita S, Izutsu K, Mishima Y, Kumode T, Kuroda J, Kanemura N, Fukuhara N, Shimada K, Mori C, Kawasaki A, Miyake T, Maruyama D•
Lower respiratory infections (LRIs) are responsible for significant morbidity and mortality in Ecuador; however, evidence to support prevention strategies is limited. This study aimed to identify age-specific trends, spatial patterns, and sociodemographic risk factors of LRI mortality in Ecuador between 2012–2022, utilizing national mortality data sourced from the Ecuadorian National Institute for Statistics and Censuses (INEC). Age-sex-specific trend analysis was performed using Joinpoint regre...
Articles
Krishna R, Furuya-Kanamori L, Lawford HLS•
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