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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,573–1,584 of 2,098 articles

PubMed

Unveiling the Limits of Anticholinergic Burden Scales: A Study of Adverse Drug Reactions in the French Pharmacovigilance Database.

Background and Hypothesis The anticholinergic burden is the cumulative effect of drugs with anticholinergic properties and is typically measured using one of several anticholinergic scales. We hypothesised that these scales may not fully capture all the relevant adverse drug reactions (ADRs). By accessing the French national pharmacovigilance database (FPVD) and focusing on drug classes known to induce anticholinergic ADRs, the objectives of the present study were to describe the reported ADRs,...

Articles
Pecquet PE, Moragny J, Gras V, Schiro P, Pinel S, Laville SM, Liabeuf S•
PubMed

Platelets/lymphocytes ratio and neutrophils/lymphocytes ratio in children with H. pylori associated gastritis: a canary in the mine?

Background Low-grade systemic inflammation and localized stomach inflammation are both brought on by Helicobacter pylori (H. pylori), which is a prevalent cause of chronic gastritis. The aim of this study was to assess the association between H. pylori positivity, severity, and both platelets/lymphocytes ratio (PLR) and neutrophils/lymphocytes (NLR) ratios in children. Methods One hundred consecutive children who underwent gastroscopy for upper gastrointestinal tract symptoms were analysed re...

Articles
Elsaadany E, El Amrousy D, Qassem SS, El Feil N, Morad LM•
PubMed

Toward dynamic graph representation of 12-lead ECG in multimodal surgical risk assessment.

To the Editor, We have reviewed with great interest the recent study by Yoon et al, which introduces a multimodal deep learning model that integrates raw electrocardiogram (ECG) waveforms with clinical data for postoperative risk prediction[1]. The authors’ use of a Transformer-based architecture to capture temporal dependencies in 12-lead ECG signals represents a meaningful step forward from conventional feature-based methods. The model’s performance clearly demonstrates the value of leveragin...

Articles
Zhao S, Zhu S, Yua B•
PubMed

Clinical evaluation of a spot-check ECG for the diagnosis of atrial fibrillation.

Background Opportunistic screening of atrial fibrillation (AF) using wearable spot-check electrocardiogram (ECG) devices has emerged for early detection, yet remains limited by concerns for accuracy and false positives. Objective This study aimed to assess the Masimo W1 wrist-wearable ECG spot-check device in detecting AF and normal sinus rhythm (NSR) while rendering diagnostic ECG waveform quality to support physician overread. Methods Participants with and without a previous AF diagnosis...

Articles
Lambert C, Ganji J, Alghazi A, Good WW, Ghafoori E, Cantillon DJ, Drury P•
PubMed

Higher Social Media Use Associated with Higher Hemoglobin A1C and Greater Diabetes Distress in Young Adults with Type 1 Diabetes.

Objective: Young adults (YA) with type 1 diabetes struggle with glycemic control and diabetes distress. As social media (SM) is highly used by YA, we explored how YA with diabetes use SM, identifying associations with demographics and diabetes measures. Research Design and Methods: We developed and emailed a survey to YA seen in clinic, aged 18–25 years with diabetes ≥1 year, querying SM, demographic, and diabetes characteristics, as well as diabetes distress (Problem Areas in Diabetes [PAID]...

Articles
Maxwell TK, Branka L, Adam A, Weitzman ER, Laffel LM•
PubMed

Running into the Lyme-light: a retrospective cross-sectional study of tick bites and Lyme disease prevalence, incidence, and prevention in hill runners, Scotland, UK.

Background Lyme disease (LD) incidence is increasing globally, driven by changes to habitat and human-vector interactions. Effective prevention relies on local and individual-level understanding of risk and ecosystem interactions. Despite frequent exposure to tick habitats, little is known about tick bites and LD risk among hill, trail, and mountain runners. This study aimed to evaluate the period prevalence of tick bites and incidence of LD in hill runners in Scotland, UK and examine preventiv...

Articles
Balfour M, Ribeiro R, Auty H, Heath A•
PubMed

Metabolic Insights From Composition-Based Analysis of Kidney Stones: A Retrospective Study of 506 Patients.

Background: Kidney stone disease is a highly prevalent condition with increasing global incidence and recurrence. The stone composition reflects underlying metabolic and biochemical alterations, and its evaluation may provide clinically relevant information for effective management. Aim: To evaluate the distribution of stone composition in a large surgical cohort and explore its association with routinely assessed metabolic parameters and recurrence patterns. Methods: This retrospective single...

Articles
Portakal S, Cakiroglu B, Uyanık BS, Aydin S, Avci AE•
PubMed

Methodological Comments to "Comparative Effects of Two Acupuncture Protocols in the Management of Chronic Insomnia: A Randomized Controlled Trial" [Letter].

Dear editor We are writing to convey our appreciation for the RCT titled “Comparative Effects of Two Acupuncture Protocols in the Management of Chronic Insomnia” recently published in Nature and Science of Sleep.1 To improve the interpretation and generalizability of its findings, we raise targeted methodological questions as follows. Blinding Effectiveness and Reporting The study adopted a single-blind design, with the treatment group in the prone position and the control group in the supine...

Articles
Zhou G, Shen P, Wan Y•
PubMed

Association Between Antibiotic Use for Nongastrointestinal Infections and Inflammatory Bowel Disease Flare-Ups: A Self-Controlled Case Series Study.

INTRODUCTION: Disruption of gut microbiota by antibiotic use has been linked to the development of inflammatory bowel disease (IBD). This study aimed to evaluate the association between antibiotic use for nongastrointestinal (GI) infections and the risk of IBD flare-ups, and to examine whether route of administration, antimicrobial spectrum, and antibiotic class modulate this risk. METHODS: We conducted a self-controlled case series study using territory-wide electronic medical records from H...

Articles
Zhang Y, Li X, Fang Q, Yang D, Bhaskaran K, Wong AYS, Leung WK•
PubMed

Editorial: Updates on pharmacogenomics role in cancer chemotherapy.

Introduction Chemotherapy continues to be a core component of cancer treatment, yet its success is frequently constrained by a “narrow therapeutic window”—some patients experience severe toxicity, while others show no tumor response. This dual challenge underscores the critical need for personalized medicine. Pharmacogenomics (PGx), the study of how genetic differences affect drug responses, presents a promising strategy for tailoring chemotherapy treatments. This Research Topic combines diver...

Articles
Elbarbry F•
PubMed

A Rare Presentation of Benign Prostatic Hyperplasia With Pure Stromal Hyperplasia as a Large Isolated Pelvic Mass With Normal Prostate Imaging.

Benign prostatic hyperplasia (BPH) is the most common benign lesion of the prostate in aging men. However, diagnosing BPH can be challenging when it presents as an exophytic pelvic mass, particularly if radiologic continuity with the prostate and prostatic glandular components are not clearly seen. Here, we report a 57-year-old male patient with a 2-year history of obstructive voiding dysfunction. Radiologic investigations, including both computed tomography and magnetic resonance imaging, revea...

Articles
Ren D, Houshyar R, Edwards RA•
PubMed

Correlation of anticoagulation assays with bleeding during extracorporeal membrane oxygenation at a tertiary pediatric hospital.

Introduction Due to anticoagulation during Extracorporeal Membrane Oxygenation (ECMO), patients face a higher risk of bleeding. This study aimed to assess the correlation between anticoagulation assays and hemorrhage in ECMO patients. Methods We reviewed records from patients in our critical care units, comparing anticoagulation parameters with clinical outcomes. Statistical analyses included the Wilcoxon rank sum test for continuous variables and chi-square or Fisher’s exact tests for catego...

Articles
Salameh M, Delgado J, Killebrew R, Henderson C, Appachi E•