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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,561–1,572 of 2,098 articles

PubMed

Intranasal unadjuvanted LcrV boosts parental Yersinia OMV primed lung immunity against pneumonic plague in mice.

Pneumonic plague remains a high-consequence respiratory disease, highlighting the need for vaccines that induce durable lung-localized immunity. We show that intramuscular prime-boost vaccination with Alum-absorbed OMV46-LcrV (OMV46-LcrV/Alum) is safe but provides limited long-term protection against respiratory Yersinia pestis challenge in mice. To enhance lung immunity, we deliver an adjuvant-free intranasal LcrV “spike” following IM OMV46-LcrV/Alum priming. This “prime-spike” regimen is well...

Articles
Majumder S, Das S, Saqib M, Van der Veer M, Acee M, Sun W•
PubMed

Prevalence, associated factors, and temporal variation of allergic rhinitis among 13 to 14-year-old adolescents from rural Sri Lanka: An analytical cross-sectional study.

Background: Allergic rhinitis is often underdiagnosed despite its high prevalence and considerable impact on academic achievement and quality of daily living. The study aims to describe the epidemiological patterns of allergic rhinitis among adolescents aged 13–14 years in Anuradhapura, Sri Lanka. Methods: An analytical cross-sectional study was conducted in 2023 among adolescents from 32 grade 8 classes in 6 government secondary schools located in the Anuradhapura municipal council area and...

Articles
Subhanee T, Thennakoon S, Sridharan PS, Siriwardhana TC, Sulakkhana S, Sumanapala V, Wijayarathna L, Warnasekara J, Rajapakse S•
PubMed

Prevalence and influencing factors of allergic rhinitis in Xi'an: A 2022 survey.

Background: The incidence of allergic rhinitis (AR) has been rising annually in China, correlating with the ongoing intensification of global climate change and industrialization. Objectives: This study aimed to investigate the self-reported prevalence of AR among adults in Xi’an, as well as the relevant influencing factors. Methods: The prevalence of AR was assessed among adult residents across 11 districts of Xi’an from June to October 2022. Additionally, an analysis was conducted to dete...

Articles
Zhang X, Gao Y, Li J, Xi L, Zhang L, Zhang Y•
PubMed

Evaluating montelukast-second-generation antihistamine combinations versus monotherapy in allergic rhinitis: A network meta-analysis.

Background: Allergic rhinitis (AR) is an atopic condition affecting over 400 million people worldwide, impairing quality of life and often leading to complications such as asthma and sinusitis. Montelukast, a leukotriene receptor antagonist, is often used in combination with second-generation antihistamines (sgAHs) to enhance symptom control. However, the relative efficacy of different montelukast-sgAH combinations remains unclear. Objective: To evaluate and compare the efficacy of montelukas...

Articles
Wandana A, Tanely JC, Sudrajat RMC, Alexandra J, Albani NNA, Seto Anggraini Widyastuti E, Sumantri S•
PubMed

Antimicrobial photodynamic therapy using sodium iron chlorophyllin against drug-resistant Cutibacterium acnes from patients with acne vulgaris.

Antimicrobial resistance in Cutibacterium acnes is a growing concern, limiting treatment options for acne vulgaris (AV) and increasing the risk of opportunistic infections. Photodynamic therapy (PDT), using an effective photosensitizer (PS) and optimized light parameters, is a potent broad-spectrum antimicrobial strategy with minimal risk of resistance development. This study aimed to assess the efficacy of PDT using sodium iron chlorophyllin (CHL-Fe) as an in-house photosensitizer (CH-PDT) agai...

Articles
Mahajindawong B, Kumtornrut C, Asawanonda P, Kerr SJ, Chatsuwan T, Boontaveeyuwat E•
PubMed

Fatal multi-drug-resistant gram-negative bacterial pneumonia among adults hospitalized àt Mulago National Referral Hospital, Uganda: an autopsy study.

Background Pneumonia, responsible for three million deaths annually worldwide, remains a leading cause of death from hospital-acquired infections. Unfortunately, treatment in most cases is empirical and not based on microbiological data because of difficulty in obtaining reliable lower respiratory tract specimens as they are frequently contaminated by upper respiratory tract bacterial flora. We examined aseptically collected lung specimens from decedents with fatal pneumonia to (a) isolate the...

Articles
Mutumba W, Kajumbula H, Lukande R, Kalungi S, Semmuli B, Banturaki G, Nakanjako D•
PubMed

Artificial intelligence in the diagnosis and prognosis of pediatric bacterial pneumonia: current advances and challenges.

Purpose of review The clinical presentation of pediatric bacterial pneumonia often overlaps with that of other respiratory conditions, posing considerable diagnostic challenges. This review evaluates the potential of artificial intelligence to improve diagnostic accuracy and prognostic evaluation for this disease. Recent findings Artificial intelligence driven diagnostic tools for pediatric bacterial pneumonia have now been validated in several studies. Clinically, these systems can rapidly p...

Articles
Ye Y, Zhou W•
PubMed

Minimal Disease Activity as A New Therapeutic Target in Atopic Dermatitis: A 5-Year Real-Life Experience With Dupilumab.

ABSTRACT Background Atopic dermatitis (AD) is a chronic inflammatory skin disease with significant physical and psychosocial burden. Dupilumab, a monoclonal antibody targeting IL‐4Rα, has proven to be effective for moderate‐to‐severe AD, but long‐term real‐world data remain limited. Objective The aim of this study is to evaluate the long‐term effectiveness, safety, and achievement of minimal disease activity (MDA) in patients with moderate‐to‐severe AD treated with dupilumab over a 5‐year pe...

Articles
Leo F, Mastorino L, Cangialosi L, Favre D, Fiasconaro CA, Liao Y, Goso F, Siliquini N, Cavaliere G, Quaglino P, Ribero S, Ortoncelli M•
PubMed

Translational Model to Predict Lung and Prostate Distribution of Levofloxacin in Humans.

Background/Objectives: Levofloxacin (LVX) is a fluoroquinolone approved for the treatment of bacterial pneumonia, sinusitis, and prostatitis. Emerging in vitro and preclinical evidence suggests that efflux transporters are involved in LVX’s target tissue site distribution. Methods: The objective of this research was to characterize tissue exposure using a physiologically based pharmacokinetic (PBPK) model to be able to make more educated choices for optimal doses using target site pharmacokineti...

Articles
Sonego Zimmermann E, Dalla Costa T, Cicali B, Almoslem M, Cristofoletti R, Schmidt S•
PubMed

Comparison of the Effective Dose 90 (ED90) and Clinical Outcomes of Fentanyl Versus Esketamine for Analgesia in Hysteroscopy: A Two-Part, Randomized, Double-Blind Trial.

Background Hysteroscopy is a minimally invasive procedure that can nonetheless elicit considerable pain, especially during cervical dilation. While fentanyl is widely used for analgesia, its application is limited by side effects such as respiratory depression. Esketamine, a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist, has emerged as a promising alternative due to its potent analgesic effects and safer profile. This study aimed to determine and compare the effective dose 90...

Articles
Du J, Li C, Huang M, Qin X•
PubMed

Identification of a thermogenic target in the dorsal raphe nucleus for weight management in mice.

Obesity emerges from a complex interplay of factors, including imbalanced interoception, genetic predisposition, and environmental cues, which ultimately disrupt body weight homeostasis1. While much research has concentrated on strategies to suppress appetite for sustained weight loss, insufficient attention has been given to counterregulatory mechanisms that promote energy expenditure. Here, we show that chronic inhibition of GABAergic neurons in the dorsal raphe nucleus and ventrolateral peria...

Articles
Moura-Assis A, Plucińska K, Meseguer D, Baleisyte A, Chen B, Pellegrino K, Parolari L, Shaked JT, Page KJ, Barrows DW, Carroll TS, Grajales-Reyes JG, Na D, Rodriguez-Diaz A, Furtado J, Isaza JU, Schiffer HH, Chen Y, Sun H, Kaushal N, Monenschein H, Barker DF, Ortuño MJ, Renier N, Cohen P, Carlton M, Heintz N, Brice NL, Friedman JM, Schneeberger M•
PubMed

Evaluating the Role of Incentive Spirometry in Asthma Management: A Prospective Controlled Study on Spirometry and Asthma Control Test Improvements.

Purpose Asthma is a chronic lung disease characterized by variable airway obstruction. Despite advancements in pharmacological treatments, interest in non-pharmacological approaches is growing, particularly for variable airway diseases like asthma. Incentive spirometry (IS) is non-pharmacological, inexpensive, safe, and accessible. This study aimed to evaluate the effects of IS on spirometry and asthma control test (ACT) parameters in asthma patients. Patients and Methods This was a prospecti...

Articles
Serce Unat D, Unat ÖS, Deniz S•