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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,549–1,560 of 2,098 articles

PubMed

Respiratory Biofeedback Training as an Adjunct Intervention in Pulmonary Rehabilitation for Late-Stage COPD: A Pilot Trial.

Chronic obstructive pulmonary disease (COPD) is associated with persistent dyspnea, reduced functional capacity, and significant cognitive and affective impairments. Pulmonary rehabilitation improves the physical and psychological condition, however residual symptoms often remain, especially in patients with advanced disease. Respiratory biofeedback training (RBT) may help modulate autonomic and emotional responses to dyspnea, offering a potential adjunctive intervention. This pilot study invest...

Articles
Lagravinese G, Castellana G, Genco M, Guglielmo M, Tagliente S, Guido P, Charitos IA, Aliani M, Battista P, Nese M, Carone M•
PubMed

Shaping the Future of Respiratory Care: A Look Into the Next Decade and Strategic Recommendations by the European Forum for Research and Education in Allergy and Airways Diseases.

Chronic respiratory diseases (CRDs) remain 1 of the leading causes of preventable morbidity and disability worldwide, affecting up to one-third of the total Western population in 2025. Recognizing the substantial burden of inflammatory airway diseases such as asthma, COPD, chronic rhinosinusitis, and respiratory allergy, the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) organized the symposium “Shaping the Future of Respiratory Care” in April 2025 in Brussels...

Articles
Bertels X, Scadding GK, Backer V, Lau S, Fokkens WJ, Barnes PJ, Sprekelsen MB, Bjermer L, Blaiss M, Borzova E, Brüggen MC, Brusselle GG, Cardell LO, Conti DM, Cornet M, De Corso E, De Groeve B, Djukanovic R, Fox AT, Gaga M, Gevaert P, Gibson P, Gray CL, Han J, Heaney L, Heffler E, Hoffmann HJ, Hopkins C, Jackson D, Jauhola O, Jesenak M, Johansen P, Khaleva E, Landis B, Lee S, Lund V, Mäkelä M, McDonald M, Melén E, Mullol J, Nieto-García A, Pavord I, Peters A, Price D, Quirce S, Ryan D, Sahlstrand-Johnson P, Scheire S, Schmid-Grendelmeier P, Schneider S, Senior BA, Shire CME, Smith PK, Szépfalusi Z, Teeling MTA, Wechsler ME, Houssiau P, Rabe KF, Hellings PW, Castro JL•
PubMed

Does differentiation syndrome in newly diagnosed acute promyelocytic leukemia warrant systemic antifungal therapy? A real-world clinical study.

To the Editor The prognosis of acute promyelocytic leukemia (APL) has significantly improved due to the widespread use of all-trans retinoic acid (ATRA) and arsenic-based agents. However, differentiation syndrome (DS) remains a common and potentially fatal complication during initial induction therapy. Characterized by unexplained fever, dyspnea, and multi-organ dysfunction, DS occurs in 17% to 48% of APL patients, with a mortality rate of 7% to 11% [1–7]. Early recognition and prompt intervent...

Articles
Jiang Y, Luo C, Yan H, Zhu L, Hu X, Xue L, Tong J, Zheng C•
PubMed

Multiple-day dexamethasone for controlling delayed chemotherapy-induced nausea and vomiting with low-emetic-risk chemotherapy.

Background Chemotherapy-induced nausea and vomiting (CINV) is a distressing adverse effect of chemotherapy that requires aggressive prevention. This study aimed to evaluate the antiemetic efficacy of a 4-day dexamethasone (DEX) regimen compared with the guideline-recommended 1-day DEX regimen against delayed CINV in patients receiving low-emetic-risk chemotherapy (LEC). Methods Pooled patient-level data from a multicenter, prospective, observational study, including 132 patients receiving LEC...

Articles
Yamashita A, Hayashi T, Shimokawa M, Harimitsu Y, Nishijima Y, Uchiyama M, Ushio S, Shiraishi C, Miyoshi T, Koutake Y, Kawada K, Matsuo K, Egawa T•
PubMed

Additive Association of ABCG2 rs4148155 and SLC22A12 rs75786299 Polymorphisms with Hyperuricemia, Gout, and Nephrolithiasis: A Hospital-Based, Case-Control Study.

Abstract Introduction This study aimed to investigate the interaction between the ABCG2 rs4148155 and SLC22A12 rs75786299 variants and their association with incident gout and nephrolithiasis in the Taiwanese population to better understand the genetic loci regulating hyperuricemia and their contribution to nephrolithiasis development. Methods This retrospective case-control study involved 35,280 adults from the Taiwan Precise Medicine Initiative database. We examined the prevalence of gout...

Articles
Lin CT, Chen IC, Chen YJ, Lin YC, Chang JC, Wang TJ, Huang WN, Chen YH, Wei CY, Lin CH, Chen YM•
PubMed

Innovative Application of Chatbots in Clinical Nutrition Education: The E+DIEting_Lab Experience in University Students.

Background/Objectives: The growing integration of Artificial Intelligence (AI) and chatbots in health professional education offers innovative methods to enhance learning and clinical preparedness. This study aimed to evaluate the educational impact and perceptions in university students of Human Nutrition and Dietetics, regarding the utility, usability, and design of the E+DIEting_Lab chatbot platform when implemented in clinical nutrition training. Methods: The platform was piloted from Decemb...

Articles
Elío I, Tutusaus K, Eguren-García I, Lasarte-García Á, Ortega-Mansilla A, Prola TA, Sumalla-Cano S•
PubMed

Comparison of the effects of microlearning and webinars on knowledge and self-efficacy of emergency medical technicians (EMTs) in the diagnosis and treatment of cardiac arrhythmias.

Background Emergency medical technicians (EMTs) are crucial for early diagnosis and treatment of cardiac arrhythmias. Continuous training is needed, and innovative methods such as microlearning and webinars may offer advantages over traditional approaches. Methods In this quasi-experimental study, 75 EMTs in Zabol, Iran (2024) were randomly assigned to microlearning, webinar, or control groups. The microlearning group received 22 short online sessions; the webinar group attended two 55-minute...

Articles
Baranipour J, Hosseini SMR, Sharifzadeh GR, Poodineh Moghadam M•
PubMed

Terpenoids: Emerging Natural Modulators for Reversing ABC Transporter-Mediated Multidrug Resistance in Cancer Chemotherapy.

Multidrug resistance (MDR) is a central cause of chemotherapy failure and tumor recurrence and metastasis, and its mechanism involves enhanced drug efflux, target mutation, upregulation of DNA repair and remodeling of the tumor microenvironment. ABC transporter protein (P-gp, MRP, and BCRP)-mediated efflux of drugs is the most intensively researched aspect of the study, but the first three generations of small-molecule reversal agents were stopped in the clinic because of toxicity or pharmacokin...

Articles
Ma L, Mahemuti D, Lan Y, Xu J, Li W, Su Z, Li J, Abuduwaili A, Maimaitijiang A•
PubMed

Water Vapor Thermal Therapy for Benign Prostatic Hyperplasia: An Umbrella Review and Updated Meta-Analysis.

Purpose Water vapor thermal therapy (WVTT) is an emerging minimally invasive therapy for benign prostatic hyperplasia (BPH). This umbrella review and updated meta-analysis aims to evaluate the comprehensive outcomes of WVTT for the management of BPH. Materials and Methods Up to January 2025, randomized clinical trials and observational studies were included in the updated meta-analysis, while systematic reviews and meta-analyses were included in the umbrella review. Both were conducted in acc...

Articles
Li Z, Wang C, Wu Y, Martínez BB, Liu J, Xiang J, Zhang X, Zhao X, Lu Y, Horie S, Gu D, Hou Q•
PLOS

Type 2 diabetes and age-related cognitive decline over 40 years in Danish men–A cohort study based on the Danish Aging and Cognition (DanACo) cohort

Aim: The extant literature on type 2 diabetes and cognitive decline is based on short cognitive follow-ups and assessments of baseline cognitive ability after diagnosis. The objective was to investigate the influence of type 2 diabetes on cognitive decline over a period of on average 44 years. Materials and methods: This cohort study included 5,147 men from the Danish Aging and Cognition cohort consisting of a late mid-life (mean age 64.2 years) follow-up of men with intelligence test scores (IQ...

Articles
Gunhild Tidemann Okholm, Marie Grønkjær, Jørgen Rungby, Erik Lykke Mortensen, Merete Osler•
PubMed

Evolocumab-Induced Angioedema: First Documented Case and Review of a Rare Adverse Event.

Background Evolocumab is a monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9, primarily used to help hyperlipidemia patients who cannot reach target low-density lipoprotein cholesterol despite statins and ezetimibe. While generally well tolerated, serious hypersensitivity reactions are rare. FIH/Early Reports Summary A 64-year-old man with familial hypercholesterolemia developed acute orofacial angioedema 4 months after starting evolocumab. There was no reported expo...

Articles
Habeb B, Derias P, Retzloff J, Kachur S•
PubMed

Structural brain differences associated with panic disorder: an ENIGMA-Anxiety Working Group mega-analysis of 4924 individuals worldwide.

Neuroanatomical findings on panic disorder (PD) are typically difficult to replicate, with inconsistent effects. These concerns prompted a paradigm shift towards large-scale collaborations, focused on harmonized data extraction and processing for robust examination of PD brain correlates. Hence, leveraging the largest-ever multi-site neuroimaging database on PD (Age: 10–66 years; global sites: 28), compiled by the ENIGMA-Anxiety Working Group, we report on cortical and subcortical differences in...

Articles
Han LKM, Bruin WB, Bas-Hoogendam JM, Groenewold NA, Hilbert K, Winkler AM, Zugman A, Asami T, Barber JP, Benedetti F, Blair RJR, Böhnlein J, Brambilla P, Breuer F, Buckner RL, Bülow R, Calkins ME, Chechko N, Dannlowski U, Dohm K, Domschke K, Dresler T, Erhardt-Lehmann A, Fonzo GA, Forstner AJ, Grabe HJ, Grotegerd D, Gur RE, Gur RC, Harmer C, Hofmann D, van den Heuvel OA, Jahanshad N, Kircher TTJ, Koch K, Laansma MA, Langhammer T, Lee SH, Leehr EJ, Maggioni E, Marino CE, Meinert S, Meinert H, Milrod B, Mwangi B, Nielsen JA, Ohrmann P, Pantazatos SP, Paulus MP, Penninx BWJH, Poletti S, Reinecke A, Ridderbusch IC, Rjabtsenkov P, Sämann PG, Satterthwaite TD, Schmaal L, Schrammen E, Soares JC, Solomonov N, Stein MB, Straube B, Straube T, Suarez-Jimenez B, Smoller JW, Talati A, Thomopoulos SI, Vazquez CE, Völzke H, Wittfeld K, Wu MJ, Yang Y, Zunta Soares GB, Lueken U, Thompson PM, Pine DS, Stein DJ, van der Wee NJA, Veltman DJ, Aghajani M•