Clinical intelligence & editorial.

PubMed

Functional dysconnectivity in reward-related circuits in adolescents with major depressive disorder with and without suicidal ideation.

Objective Adult major depression (MDD) studies implicate reward- and control-network dysconnectivity in suicidality, but it is unclear whether analogous alterations characterize adolescents, whose neural systems are still maturing. Methods Resting-state fMRI was obtained from 102 adolescents (12–17 years): 21 MDD with suicidal ideation (SI), 33 MDD without SI, and 48 matched healthy controls. Seed-based analyses targeted bilateral nucleus accumbens (NAc), ventral tegmental area (VTA), and bil...

Major Depressive Disorder

Hsu JW, Huang WS, Cheng LK, Chen LC, Chen LF, Bai YM, Tu PC, Chen MH• January 14, 2026

PubMed

Prevalence and Related Factors of Suicide Attempts in Inpatients with Major Depressive Disorder in China: A Large-Scale Cross-Sectional Study.

Background: Major depressive disorder (MDD) is often linked to a high likelihood of suicide attempts (SAs). This study investigated the incidence of SAs among patients with MDD and the associated clinical and demographic factors. Methods: A total of 3200 hospitalized patients diagnosed with MDD were enrolled at the Fourth People’s Hospital of Hefei, China, between May 20, 2022, and June 28, 2024. Data collection included demographic characteristics and biochemical profiles. Results: A total...

Major Depressive Disorder

Zhang L, Zhou C, Wang Z, Wang Y, Cheng J, Yu T, Sun G, Zhang X• January 14, 2026

PubMed

PreBP: an interpretable, optimized ensemble framework using routine complete blood count for rapid pathogen identification in bacterial pneumonia.

Introduction Bacterial pneumonia remains a major global health challenge, and early pathogen identification is important for timely and targeted treatment. However, conventional microbiological diagnostics such as sputum or blood culture are labor-intensive and time-consuming. Methods We propose an interpretable ensemble learning framework (PreBP) for rapid pathogen identification using routinely available complete blood count (CBC) parameters. We analyzed 1,334 CBC samples from patients with...

Bacterial Pneumonia

Hao X, Liang D, Shen Y, Sun C, Lan W• January 14, 2026

PubMed

Trends in fentanyl-containing drug samples seized by law enforcement agencies across Canada.

Abstract Background and aims Canada's drug toxicity crisis has been largely attributed to a volatile fentanyl‐dominated unregulated drug supply with increasing reports of fentanyl detected in combination with benzodiazepines, stimulants and xylazine. Although rates of opioid‐related harms vary significantly by region, it remains unknown how the composition of the unregulated drug supply differs across Canada. Therefore, we sought to describe trends in Canadian fentanyl‐containing drug seizures...

Fentanyl

Ledlie S, Garg R, Leece P, Kolla G, Hyshka E, Tadrous M, Gomes T• January 14, 2026

PubMed

Reducing Glucocorticoid Burden in Lupus with Omega-3 Fatty Acids: Docosahexaenoic Acid Augments Prednisone Efficacy in Maintaining Cyclophosphamide-Induced Remission of Preclinical Lupus Nephritis.

Background: Managing lupus nephritis (LN) remains challenging due to relapses after immunosuppressive induction and toxicity from long-term glucocorticoid (GC) maintenance therapy. Dietary omega-3 fatty acids prevent LN onset in preclinical models, but their role in maintaining remission post-induction remains unstudied. Methods: The silica-accelerated LN (SALN) model using lupus-prone NZBWF1 mice was used to evaluate how docosahexaenoic acid (DHA), an omega-3 fatty acid, influenced LN remiss...

Prednisone

Anderson AN, McDonald OF, Johnson SS, Liddle JJ, Estrada V, Jackson JT, Lewandowski RP, Wagner JG, Harkema JR, Pestka JJ• January 14, 2026

PubMed

Triamcinolone acetonide-loaded chitosan-polyethylene glycol hydrogel for preventing esophageal stricture post-endoscopic submucosal dissection.

Abstract Postoperative esophageal stricture remains a significant challenge following endoscopic submucosal dissection (ESD), with limited effective prophylactic options in clinic. Here, we report the development of an injectable and tissue-adhesive hydrogel drug delivery system composed of quaternary ammonium chitosan and polyethylene glycol (QCS-PEG), which was loaded with triamcinolone acetonide (QCS-PEG@TA), designed to mitigate post-ESD strictures. In vitro assays demonstrated that the hyd...

Triamcinolone Acetonide

Li Y, Gao R, He Z, Liu K, Feng Z, Huang P, Zhang C, Hou H, Xu B, An J, Zhao Y, Wang W, Zhang S, Li P• January 14, 2026

PubMed

The Impact of Nurse Practitioner Full Practice Authority on Chronic Condition-Related Readmissions and Emergency Department Visits in the United States.

Background: Chronic conditions affect over 60% of US adults and drive nearly 90% of the nation’s $4.9 trillion in annual health care costs. Nurse practitioners (NPs), particularly in Full Practice Authority (FPA) states, may be critical to improving outcomes and reducing health care burdens. Objectives: To evaluate whether nurse practitioner FPA reduces hospital readmissions and emergency department visits related to chronic conditions across the United States. Research Design: A secondary...

Nurse Practitioner

Fitzpatrick JJ, Mehlman MJ, Plemmons A, Duffy EG, Votruba M, Gerlick JA, Davis S, Norful AA• January 14, 2026

PubMed

Light Therapy Alleviates Addiction-Related Symptoms and Reshapes Habenula and Midbrain Pathways.

ABSTRACT The treatment of internet gaming disorder (IGD) poses a significant challenge. Light therapy has demonstrated efficacy in preventing cocaine‐driven reinstatement in a rodent model. The potential of light therapy, along with its underlying neural mechanisms, in treating IGD remains largely uninvestigated. A total of 104 participants are included in the RCT and 69 in the fMRI analysis. The intervention involves 14 daily sessions of light therapy, light placebo, or cognitive training. At...

Light Therapy

Li J, Huang H, Hu C, Zhang X, Lin S, Huang X, Yuan TF, So KF, Huang L, Ren C, Tao Q• January 14, 2026

PubMed

[Pain and pain management in a nursing home : Results of a cross-sectional study].

Hintergrund Pflegeheimbewohner_innen leiden häufig unter schmerzverursachenden Erkrankungen. Gemäß dem biopsychosozialen Modell von Egle et al. können Schmerzen auf unterschiedlichen Dimensionen die Betroffenen beeinträchtigen. Jedoch werden bei der Behandlung die unterschiedlichen Schmerzdimensionen häufig nicht berücksichtigt, und in vielen Fällen werden Schmerzen seitens des Pflegepersonals nicht identifiziert. Diese Studie zielt darauf ab, die Schmerzprävalenz sowie die gesetzten Interventi...

Pain Management

Pichler E, Schoberer D, Eglseer D, Strobl W, Hödl M• January 14, 2026

PubMed

Integrating Preoperative Preserved Ratio Impaired Spirometry and Inflammatory Markers to Predict Postoperative Complications and Survival in Esophageal Squamous Cell Carcinoma After Neoadjuvant Therapy.

Background Severe postoperative complications (SPCs) adversely affect outcomes in esophageal squamous cell carcinoma (ESCC) following neoadjuvant therapy. The prognostic significance of preserved ratio impaired spirometry (PRISm) and inflammation-based biomarkers such as the systemic inflammation response index (SIRI) and lymphocyte-to-monocyte ratio (LMR) remains unclear. Methods We retrospectively analyzed 224 ESCC patients who underwent esophagectomy after neoadjuvant therapy. PRISm was de...

Spirometry

Xie Q, Lin Q, Zhan J, Chen C, Zheng B, Xu G, Zhu Y, Yang Z• January 14, 2026

PubMed

Interaction between ELMO1 DNA methylation and Med31 promotes H. pylori-induced gastric cancer EMT and intestinal metaplasia via M2 polarization.

Gastric cancer (GC) is primarily associated with Helicobacter pylori (H. pylori) infection, which disrupts gastric mucosa homeostasis, leading to epithelial-mesenchymal transition (EMT) and intestinal metaplasia (IM). We previously found that ELMO1 methylation increased with the progression of chronic gastric inflammation, and its expression was significantly elevated in GC tissues. Further analysis indicated that ELMO1 methylation may interact with Med31. This paper aims to determine the molecu...

H. Pylori

Lu T, Yu T, He C, Huang B, Wang F, Zhang L, Song J• January 14, 2026

PubMed

The pediatric nasal microbiome and its role in chronic ENT disorders: a narrative review.

The human microbiome is increasingly recognized as a key factor in immune development and disease susceptibility, especially in early life. Nasal microbiome has emerged as a critical element in upper airway health, yet its role in pediatric otorhinolaryngological conditions remains underexplored. This narrative review synthesizes current evidence on the microbial nasopharyngeal patterns in healthy children compared with children suffering from chronic ENT conditions such as otitis media, allergi...

Ent

Sîrbu AE, Gradisteanu Pircalabioru G, Deaconu DM, Andronic O, Gheorghe DC• January 14, 2026