Clinical intelligence & editorial.

PubMed

Exploring the Anti-Inflammatory Effects of Aloe vera Flower (AVF) and Its Active Ingredients in a Skin Inflammation Model Induced by Glyoxal-Derived Advanced Glycation End Products (GO-AGEs).

Objective: Advanced glycation end-products (AGEs) contribute to oxidative stress and inflammation, leading to various disorders, including skin inflammation. Here, we investigated the anti-inflammatory effects of Aloe vera flower (AVF) extract and its active constituents, vitexin (V) and isovitexin (IV), in a glyoxal-derived AGE (GO-AGE)-induced skin inflammaging model. Methods: We evaluated the effects of AVF, V, and IV in epidermal keratinocytes (HaCaT cells) using enzyme-linked immunosorbent...

Articles

Lee EY, Hong SM, Kim SY, Sultana R• January 9, 2026

PubMed

Patient Perceptions of Ozempic (Semaglutide) for Weight Loss: Mixed Methods Analysis of Online Medication Reviews.

Background Ozempic (semaglutide) has received widespread attention for its appetite-suppressing effects, leading to extensive off-label use for weight loss. Although gastrointestinal side effects are well documented, less is known about how users assess the trade-off between perceived benefits and adverse effects, or how these assessments influence treatment discontinuation. Importantly, existing insights are often limited to clinical trial populations and may not fully reflect real-world exper...

Articles

Armanious AJ, Hunter RM, Griffiths KR, Bowrey HE, Brown RM, James MH• January 9, 2026

PubMed

The efficacy of carvedilol in improving cardiac function and survival in patients with anthracycline-induced cardiotoxicity: a comprehensive systematic review and meta-analysis.

Background Anthracyclines (ANT) are widely used in chemotherapy, but their dose-dependent Cardiotoxicity limits long-term use. Carvedilol, a non-selective beta-blocker, has shown potential as a Cardioprotective agent for patients receiving ANT, though its overall effectiveness remains unclear. This systematic review and meta-analysis aimed to assess the impact of carvedilol on cardiac function and survival in patients with anthracycline-induced Cardiotoxicity. Methods We performed a comprehen...

Articles

Abbasi SUAM, Bhagwan R, Rehman A, Malik N, Khaskheli SA, Rajpar NA, Nabi R, Basra AA, Meghwar S, Ahmed R, Singh K• January 9, 2026

PubMed

Chlamydia psittaci pneumonia in a patient using ustekinumab therapy for Crohn's disease.

ABSTRACT Background Ustekinumab, a monoclonal antibody targeting the p40 subunit of interleukin-12 and interleukin-23, is widely used for immune-mediated diseases such as Crohn’s disease. By modulating Th1 and Th17 pathways, ustekinumab may increase susceptibility to intracellular pathogens. We report the first case of Chlamydia psittaci pneumonia in a patient treated with ustekinumab. Case Summary A 27-year-old woman with Crohn’s disease presented with severe community-acquired pneumonia, p...

Articles

Dirks JAMC, Mulder L, Burgers K, Damoiseaux JGMC, Heddema ER• January 9, 2026

PubMed

Pediatric Cardiology Echocardiography Curriculum and Workshop for Pediatric Residents in Mwanza, Tanzania-Using Deliberate Practice for Skill Acquisition.

Bugando Medical Center (BMC) in Mwanza, Tanzania, with two hundred pediatric beds, has a large burden of pediatric heart disease. The general pediatric residents are front-line cardiology providers. At the time of this study, there was a single pediatrician with echocardiography training, performing all echocardiograms and providing trainee education, teaching residents on-the-job with limited access to continued education. Our aim was to build pediatric residents’ cardiac ultrasound capacity at...

Articles

Patel SG, Acevedo J, Patel A, Fant C, Mushi T, Kabrigi J, Masoza T• January 9, 2026

PubMed

Can a Benign Hematology Phenomenon Critically Impact the Neutropenia Status and Treatment of Patients With Cancer?

Neutropenia in oncology care usually has a disease-related or therapy-related etiology. However, for a population with a benign hematology phenomenon known as benign ethnic neutropenia (BEN) or Duffy-null associated neutrophil count (DANC), neutropenia can be unexpected or more severe during oncology care. A lack of awareness of this phenomenon and its impact can lead to actions that result in treatment delays, dose reductions, or even treatment discontinuation. Additionally, patients may be exc...

Articles

Ndje AP• January 9, 2026

PubMed

Comparative study between female patients with functional dyspepsia accompanied by abnormal urinalysis and those with urinary tract infections: a retrospective case-control study.

Functional dyspepsia (FD) in female patients can present with abnormal urinalysis results, which may differ from those of urinary tract infections (UTIs). This study is to analyze and compare the differences in urinalysis indicators between the two conditions. We retrospectively collected data from 120 female patients diagnosed with either FD or UTI, with 60 patients in each group. We analyzed and compared the levels of urinary abnormal indicators using the Mann-Whitney U test and Chi-square tes...

Articles

Liao Y, Li Y, Wang X, Pu F, Yong G, Ming W, He G• January 9, 2026

PubMed

Nitrite Dipstick Urinalysis as a Point-Of-Care Test for Sodium Nitrite Poisoning.

Background: Intentional sodium nitrite poisoning is an emerging trend worldwide, as it is promoted for its use in self-euthanasia. Nitrite dipstick urinalysis could potentially serve as a rapid-diagnostic tool. Urine dipstick analysis is a common point-of-care test (POCT) for the initial diagnosis of urinary tract infections. The aim of this study was to investigate nitrite dipstick urinalysis as a potential reliable POCT for the early detection of sodium nitrate poisoning. Methods: Postmorte...

Articles

Bethlehem C, Vleut IT, Augustijn D, Michielse J, Limmen R, Verweij JL, Dekker D, Koch BCP, Hassanzai M• January 9, 2026

PubMed

Development of an Intelligent Clinical Decision Support System for Spirometry Quality Control.

Background: Spirometry is the most widely used pulmonary function test for diagnosing respiratory diseases. However, the quality of the results mainly depends on the correct execution of the maneuver, making quality control essential. Traditionally, this process relies on subjective and laborious visual inspection. Methods: To overcome these limitations, this work proposes an intelligent clinical decision support system to assist in spirometry quality control. The proposed system generates a gra...

Articles

López-Canay J, Priegue-Carrera A, Casado-Trigo A, Represas-Represas C, Fernández-García A, Comesaña-Campos A, Casal-Guisande M, Fernández-Villar A• January 9, 2026

PubMed

The Predictive Value of Nomogram Model Based on Neutrophil-to-Lymphocyte Ratio (NLR) and Prothrombin Time-International Normalized Ratio (PT-INR)-to-Albumin Ratio (PTAR) for Early Bacterial Intra-Abdominal Infection After Orthotopic Liver Transplantation.

Purpose To identify risk factors for bacterial intra-abdominal infections (IAIs) after orthotopic liver transplantation (OLT) and establish a nomogram prediction model based on preoperative neutrophil-to-lymphocyte ratio (NLR) and preoperative prothrombin time-international normalized ratio (PT-INR)-to-albumin ratio (PTAR). Patients and Methods We retrospectively analyzed 261 patients who received OLT between January 2020 and April 2024 in Beijing Friendship Hospital. Independent risk factors...

Articles

Peng HB, Liu Y, Hou F, Zhao S, Zhang YZ, He ZY, Cui TT, Liu JY, Xiong HF, Sun LY• January 9, 2026

PubMed

Impact of an electronic clinical decision support algorithm (eCDSA) on antibiotic prescribing in primary care in Cambodia: A cluster randomised controlled trial.

Objectives Poorly targeted antibiotic use in primary care is a driver of antimicrobial resistance. Electronic clinical decision support algorithms (eCDSAs) integrating point-of-care tests may improve prescribing. We evaluated the impact of an eCDSA on antibiotic prescriptions among febrile patients attending primary health centres in Cambodia. Methods In this cluster randomised controlled trial, 30 PHCs in Battambang Province were randomised (1:1) to either adopt the eCDSA or routine care. Th...

Articles

Wynberg E, Mishra A, Liverani M, Vanna M, Chanpheakdey P, Chaikul K, Suy K, Bory S, Voeurng B, Callery JJ, Chandna A, Adhikari B, Chamsukhee V, Waithira N, Tubprasert J, Poonchai A, Davoeung C, Rekol H, Nguon C, Dysoley L, Day NPJ, Fegan G, Peto TJ, Lubell Y, Chew R• January 9, 2026

PubMed

Endoscopic Topical Application (ETA) Therapy for Refractory Overactive Bladder: A First-in-Human Report.

Refractory overactive bladder (OAB) remains a clinical challenge despite established therapies, such as anticholinergics, β3-agonists, and intradetrusor botulinum toxin (BTX). Emerging evidence suggests that sensory mechanisms within the bladder, including those involving the trigone where superficial afferent networks are present, may contribute to persistent urinary urgency and frequency in some patients. Although intradetrusor BTX injection is effective in selected patients, its impact on the...

Articles

Sadahira T, Sugihara M, Mitsui Y, Watanabe T, Araki M, Watanabe M• January 9, 2026