Sign in Register

Clinical intelligence & editorial.

Advertisement

Advertisement

Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,657–1,668 of 2,098 articles

PubMed

A Glutamatergic Medial Prefrontal Cortex-Locus Coeruleus Circuit Drives Intestinal Dysmotility in Diarrhea-Predominant Irritable Bowel Syndrome.

Diarrhea-predominant irritable bowel syndrome (IBS-D) is a common chronic disorder of gut–brain interaction characterized by intestinal dysmotility. Central sensitization has a proposed role in intestinal dysmotility, yet the precise neural circuits and mechanisms remain poorly understood. In this study, we established a neonatal maternal deprivation plus restraint stress (NMD + RS) mouse model that recapitulates key diarrhea-like phenotypes. Neural activation mapping revealed a significant upre...

Articles
Jia SM, Wang KQ, Hu SF, Weng RX, Liu K, Sun Q, Li R•
PubMed

Hypoglycaemia and Cardiac Arrhythmias in Type 1 Diabetes Mellitus: A Mechanistic Review.

Hypoglycaemia in patients with type 1 diabetes mellitus (T1DM) remains a major clinical burden and, beyond its metabolic complications, can cause serious cardiac arrhythmias. Multiple mechanisms lead to different types of arrhythmias during hypoglycaemia. However, existing studies often involve mixed diabetes populations, small cohorts, or limited monitoring during nocturnal periods, leaving a critical gap in understanding the links between glucose fluctuations and arrhythmic events. This review...

Articles
Mavromoustakou K, Fragoulis C, Cholidou K, Sotiropoulou Z, Anagnostopoulos N, Gastouniotis I, Lontou SP, Dimitriadis K, Thanopoulou A, Chrysohoou C, Tsioufis K•
PLOS

Delivering culturally adapted family interventions for people with schizophrenia in Indonesia: A feasibility randomised controlled trial and nested process evaluation

Schizophrenia is a severe and enduring illness with high relapse rates leading to functional impairment. Although family interventions effectively reduce relapse, most evidence originates from high-income settings. This single-masked feasibility trial randomised 74 service-user–carer dyads to receive either a culturally adapted family intervention or treatment as usual. The intervention was delivered by non-specialist healthcare workers through a task-shifting approach integrated into primary ca...

Articles
Laoise Renwick, Helen Brooks, Budi-anna Keliat, Dewi Wulandari, Rizqy Fadilah, Raphita Diorarta, Suherman, Georgia Addison, Penny Bee, Karina Lovell, Herni Susanti•
PLOS

Retraction: Metformin attenuates osteoclast-mediated abnormal subchondral bone remodeling and alleviates osteoarthritis via AMPK/NF-κB/ERK signaling pathway

After this article [ 1 ] was published, concerns were raised about the results presented in Figs 3 and 7. Specifically, the following figure panels appear similar: Fig 3C RANKL 50 ng/mL + Met-0 μM day 3 panel of [ 1 ] and Fig 2A RANKL-50 ng/mL + DHA-5 μM panel of [ 2 ]; upon editorial follow-up, the second author stated that Fig 3C RANKL 50 ng/mL + Met-0 μM day 3 panel of [ 1 ] is incorrect. Fig 7A 4 weeks sham-operated panel* of [ 1 ] and Fig 7E left panel of [3, retracted in 4]; upon edi...

Articles
The PLOS One Editors•
PLOS

Retraction: Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway

After this article [ 1 ] was published, concerns were raised about Figs 3, 4, and 7. Specifically, the following figure panels appear similar: Fig 3D RANKL‑100 ng/ml CUR 10 μM day 3 panel of [1] and Fig 6A Sham+PBS panel of [2, retracted in 3]. Fig 4C RANKL-100 ng/ml CUR-0 μM panel and the central region of the Fig 4C RANKL-100 ng/ml CUR-10 μM panel when enlarged. Fig 7A 8 weeks OA+CUR panel* of [1] and Fig 7B 8 weeks DMM+Met panel of [4, retracted in 5]. Fig 7B 4 weeks OA+vehicle pa...

Articles
The PLOS One Editors•
PLOS

Retraction: Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption

After this article [ 1 ] was published, concerns were raised about Figs 2 and 6. Specifically, the following figure panels appear similar: Fig 2A 8 weeks DMM+PBS panel of [1] and Fig 8B 8 weeks Sham-operated coronal panel of [2]. Fig 6A sham+PBS panel of [1] and Fig 3D day 3 RANKL-100 ng/ml CUR-10 μM panel of [3, retracted in 4]. Upon editorial follow-up, data underlying the panels of concerns were provided; however, these data were not sufficient to resolve the concerns listed above an...

Articles
The PLOS One Editors•
PLOS

Pharmacokinetics and analgesic efficacy of fentanyl and buprenorphine in chicken embryos

Chicken embryos are able to process and receive noxious stimuli from embryonic day (ED) 13. In the context of animal welfare, analgesic refinement is highly recommended for painful procedures from this time onwards. In this first study, the pharmacokinetic and pharmacodynamic profiles of the opioid analgesics fentanyl (0.2 mg/kg) and buprenorphine (0.5 mg/kg) were studied in ED17 chicken embryos. Analgesic plasma concentrations were determined at different time points after administration via LC...

Articles
Luis Truhlar, Julia Werner, Marie-Louise Schmid, Aylina Glasenapp, Heike Baehre, Judith Reiser, Julia Koerner, Heidrun Potschka, Marion Bankstahl, Christine Baumgartner•
PLOS

The prevalence and associated factors of uncontrolled blood pressure in a rural community of Nepal: A cross-sectional study

Hypertension affects 1.28 billion adults globally, with two-thirds residing in low- and middle-income countries. In Nepal, about 60% of hypertensive individuals in urban settings have uncontrolled blood pressure, but the situation in rural settings is unknown. We aimed to determine the prevalence and factors associated with uncontrolled blood pressure among individuals diagnosed with high blood pressure, in a rural community in Nepal.We conducted a cross-sectional study among 1,008 individuals a...

Articles
Bihungum Bista, Sushmita Mali, Kjersti Mørkrid, Meghnath Dhimal, Biraj Man Karmacharya, Archana Shrestha•
PLOS

Relationship between the Rate of Perceived Stability, electrodermal activity and task performance during balance challenges in chronic stroke

Introduction: In addition to sensorimotor impairments following stroke, decreased self-efficacy regarding walking balance may lead to self-imposed limitations on community level mobility, especially among women. The Rate of Perceived Stability (RPS) is a self-efficacy measure used to assess individual perception of balance ability when standing or walking balance is challenged. Measurement of electrodermal activation (EDA), modulated by the autonomic nervous system, during perturbations to stand...

Articles
Aishwarya Shenoy, Amy Schneeberg, Towela Tembo, Rebecca M. Todd, Noah D. Silverberg, Janice J. Eng, Tzu-Hsuan Peng, Peyman Servati, Courtney L. Pollock•
PLOS

The effectiveness of smart healthcare for patients with rheumatoid arthritis: A systematic review and meta-analysis

Objectives: This study aimed to evaluate the impact of smart healthcare interventions on disease activity, self-efficacy, self-management, functional levels, and quality of life in rheumatoid arthritis (RA) patients, as well as any associated adverse events. Method: A systematic search was conducted in PubMed, EMBASE, and Cochrane Library for randomized controlled trials (RCTs) from inception to August 2024, using relevant medical subject headings and keywords. The Cochrane risk of bias tool was...

Articles
Yin Yu, Meijiao Wang, Hejing Pan, Lin Huang, Haichang Li, Xuanlin Li•
PubMed

A cross-sectional study on clinical vigilance in the diagnosis and treatment of listeriosis among pregnant women and their knowledge, attitudes, and practices regarding listeriosis in Gansu Province, China.

Background Listeriosis is a serious foodborne disease that threatens the health of pregnant women and their fetuses. Gansu Province, in northwest China, is economically underdeveloped and covers a large geographic area. No population-based studies on listeriosis have been conducted there. In 2022, Gansu added listeriosis to its foodborne disease surveillance system and started a pilot program at five tertiary hospitals in four cities. By the end of 2024, 13 confirmed cases had been reported, in...

Articles
Lin WX, Wang KL, Sang XL, Shi ZY, Liang XC•
PubMed

Persistent effects of neonatal diarrhea on Holstein dairy cow lactation performance through multiple parities.

Abstract Calf diarrhea, one of the most common stresses causing by heifer rearing, affects most Chinese dairy herds, yet its long-term consequences on lactation performance remain poorly quantified. This study explored whether calf diarrhea has a long-term effect on the lactation performance and Dairy Herd Improvement-related indices of dairy cows and its influence during different lactation periods. This retrospective study included a total of 1,907 Holstein dairy cows from a large-scale farm...

Articles
Hou X, Xu J, Ren J, Liu G, Wang X, Du Q, Niu Z, Cao Y, Tong D, Wu S, Yao J•