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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,741–1,752 of 2,098 articles

PubMed

Multidimensional analysis of smartphone overuse in insomnia: Integrating digital phenotyping with clinical assessment.

Abstract Background and aims This study aimed to identify the differences in characteristics between high- and low-risk smartphone users among individuals with insomnia symptoms using digital phenotyping and clinical assessments. Methods A total of 246 participants with insomnia symptoms (M = 31.14, SD = 10.09) were monitored for four weeks using the smartphone application and wearable devices. The participants were divided into high-(n = 141) and low-risk (n = 105) smartphone overuse groups...

Articles
Matsushita E, Kim H, Kim M, Yoon S, Kim S, Yeom JW, Pack SP, Lee HJ, Cheong T, Cho CH•
PubMed

Effects of an online organizational intervention targeting managers in nursing homes on caregivers' low back pain and managers' work engagement: a cluster randomized controlled trial.

Abstract Objectives To examine whether an online organizational intervention targeting managers in nursing homes could promote occupational health activities and reduce caregivers’ low back pain. Methods This 6-month, prospective, cluster randomized controlled trial was conducted between January and July 2024. Nursing homes in Fukuoka Prefecture, Japan were randomly assigned to an online program-intervention group (n = 25) or an active control group (n = 25). The intervention combined an ori...

Articles
Tani N, Ebara T•
PubMed

Effectiveness of exercise interventions for chronic low back pain among office workers: a systematic review and meta-analysis.

Abstract Objectives Chronic low back pain (LBP), largely attributable to prolonged sitting and low levels of physical activity, is prevalent among office workers and constitutes a major occupational health concern. Although exercise therapy is widely recommended for chronic LBP, limited studies specifically target office workers. In this study, we systematically evaluated the effectiveness of exercise interventions for office workers with chronic LBP, focusing on pain intensity, functional dis...

Articles
Yamano H, Urata R, Ogawa K, Hatade T, Shimada R, Yokoyama H, Tanaka H, Mori K, Suetake S•
PubMed

Hereditary angioedema: on-demand treatment and long-term prophylaxis-a global reality.

Abstract Hereditary angioedema (HAE) is a rare disorder of recurrent swellings of the subcutaneous and/or mucosal tissues due to defects in the contact system regulation of bradykinin production. The swellings can be disfiguring, cause debilitating abdominal pain, or be fatal with laryngeal obstruction. Over the last decade, there have been immense successes in management of HAE owing to the development of drugs targeting the contact system. This review focuses on management of HAE due to C1-es...

Articles
Akhoon C, Kiani-Alikhan S•
PubMed

What is the psychological and cognitive impact of returning Alzheimer disease dementia research results to healthy research participants? a delayed-start randomised clinical trial protocol for the WeSHARE study (Washington University study of having Alzheimer disease research results explained).

Abstract Introduction Returning research results that indicate risk of Alzheimer disease (AD) dementia—a disease for which no meaningful treatments or cure exist—to cognitively normal participants is controversial. AD is thought to begin many years before clinical signs and symptoms begin. During this time, individuals are cognitively normal but have biomarkers that indicate pathophysiological changes in the brain. With this study, we aim to evaluate the impact of returning research results on...

Articles
Hartz SM, Goswami S, Oliver A, Evans A, Jackson S, Linnenbringer E, Moulder KM, Morris JC, Mozersky J•
PLOS

Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model

Objectives: This study aimed to evaluate the toxicity and antibacterial efficacy of Cefotaxime/Polymyxin B combination (CTX/PMB) against a polymyxin-carbapenem-resistant (PC-R) Klebsiella pneumoniae strain, using a mice model. Methods and results: A single-dose toxicity assay was conducted in BALB/c mice, divided into control and CTX/PMB-treated groups receiving low, medium, or high CTX doses. Body weight, food, and water intake were monitored for 14 days. After euthanasia, organ weights and pla...

Articles
Mariana Carvalho Sturaro, Nathalia da Silva Damaceno, Gleyce Hellen de Almeida de Souza, José Eduardo Souza Echeverria, Ediane Bortolotte Cornelius, Luccas Pereira Pires, Pedro Vinícius Dias Bassetto Silva, Bárbara Maria Cristaldo Gomes, Thiago Leite Fraga, Osmar Nascimento Silva, Luana Rossato, Simone Simionatto•
PLOS

Prevalence and morphometry of the fabella in cadaveric and radiological studies: Is there a link to knee osteoarthritis?

Objective: To investigate the morphometric features of the fabella in cadaveric specimens and evaluate its prevalence and potential association with knee osteoarthritis through radiological analysis. Methods: In the cadaveric study, 65 knees from 32 cadavers and 3 leg specimens were dissected. Fabellas were measured and analyzed histologically. In the radiological study, bilateral knee X-rays of 1712 patients with osteoarthritis and 2304 control subjects were retrospectively reviewed. The presen...

Articles
Ebru Yolaçan, Nurcan Ercıktı, Barış Baykal, Uğur Bozlar, Necdet Kocabıyık, Mehmet Ali Güner, Necati Salman, Ayşe Özdemir, Mislina Utlu, Laçin Ramazanlı•
PLOS

Correction: Perceptions and practices of community pharmacists towards the use of short-acting beta-2 agonists inhalers in Malaysia: A cross-sectional survey

The Funding statement for this article is incorrect. The correct Funding statement is as follows: The study was supported by the Research and Innovation Division (RMCO) of Universiti Sains Malaysia through a Short Term Research Grant [reference number 304/PFARMASI/6315769].

Articles
Zhe Chi Loh, Rabia Hussain, Bayan Faisal Ababneh, Jaya Muneswarao, Siew Chin Ong, Anees ur-Rehman, Zaheer-Ud-Din Babar•
PLOS

Predictors and prevalence of labor pain management practice at West Guji zone, Southern Ethiopia, 2024

Childbirth is a painful experience for most women, and many require assistance with pain relief. Strategies for managing labor pain include both non-pharmacological and pharmacological intervention. Childbirth is a painful experience for almost all women. The pain that women experience during labor is affected by multiple physiological and psychosocial factors and its intensity can vary greatly. Most women in labor require pain relief. This study aimed to evaluate the practices of managing labor...

Articles
Misgana Desalegn Menesho, Girma Tufa Melesse•
PLOS

Research on the establishment of a four-classification model for breast mass ultrasound images based on transfer learning

Breast mass classification via ultrasound is critical for early diagnosis but remains challenging due to overlapping morphological features. This study evaluates the efficacy of optimized transfer learning (TL) based on deep convolutional neural networks (DCNNs) in distinguishing four breast mass categories: invasive ductal carcinoma (IDC), fibroadenoma (FA), mucinous carcinoma (MC), and inflammatory mass (IM). Our approach comprises four key steps: (1) applying extensive data augmentation to a...

Articles
Jinlao Li, Bo Zhao, YongQi Chen, Guang Wang, XueLiang Tian, ShuYu Zhou•
PLOS

Correction: Antihypertensive therapy to prevent cardiac death: A study of combined ACE inhibitors and β-blockers—a retrospective cohort study in Tsunan Town, Japan

In Fig 1 , the label “Cardiac Deths” should have been “Cardiac Death”. Please see the correct Fig 1 here. 10.1371/journal.pone.0340417.g001 Fig 1 Five-year Trends in SMR for All-cause and Heart Disease Mortality (ICD-10: I20–I52). SMR, standardized mortality ratio. Blue line represents the entire country; Orange line represents Tsunan. In the Acknowledgement statement, the name“T. Yasuzawa” should have been “T. Anzawa”. The correct statement is: We express our deepest gratitude to M. Tsuchiya...

Articles
Shinichiro Ishikawa, Yusaku Hayashi, Toshiyuki Abe, Susumu Tanaka•
PLOS

Correction: Depression as a risk factor for Alzheimer’s disease: A human post-mortem study

The Funding statement for this article is incorrect. The correct Funding statement is as follows: We are grateful to the Alzheimer’s Society (grant 518) and the Elizabeth Blackwell Institute at the University of Bristol and the Wellcome trust institutional strategic support fund (204813/Z/16/Z) who supported Dr. Sinclair and Dr. Morisaki during this research project. Prof. Khandaker is supported by the Wellcome Trust (Grant No. 201486/B/16/Z), the Medical Research Council, UK (Grant No. MC_UU_00...

Articles
Mizuki Morisaki, Farnoosh Rezaali, Laurie C. Lau, Delphine Boche, Golam M. Khandaker, Gustavo Turecki, Lindsey I. Sinclair•