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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,801–1,812 of 2,098 articles

PubMed

AMSC-sEVs Ameliorated Crohn's Disease by Inhibiting Macrophage-Myofibroblast Transition Through the Delivery of MFGE8.

ABSTRACT This study elucidates the critical role of macrophage‐myofibroblast transition (MMT) in the pathogenesis of intestinal fibrosis in Crohn's disease (CD). Through analysis of stricturing intestinal tissues from CD patients and TNBS‐induced CD mouse models, we demonstrated that TGF‐β1 activates the MAPK signalling pathway to induce MMT in macrophages (Mø), resulting in increased expression of α‐SMA and collagen production. Importantly, these MMT‐derived myofibroblasts secrete CCL17, which...

Articles
Xie M, Liu Q, Xiong Z, Li J, Jin R, Lian L, Li Z•
PubMed

Orofacial granulomatosis in pediatric Crohn's disease: clinical outcomes and genetic background in the era of biologics: a retrospective study in Japan.

Background/Aims Occasionally, pediatric Crohn’s disease (CD) may develop after diagnosis of orofacial granulomatosis (OFG), which is characterized by chronic granulomatous lesions of the oral mucosa, lips, and perioral area. This study aimed to clarify clinical characteristics, treatment responses, and potential genetic contributors in pediatric patients with CD complicating OFG. Methods We studied pediatric patients with CD complicating OFG who were treated from 2013 to 2022 at 7 Japanese in...

Articles
Nambu R, Naito T, Haruyama M, Hosokawa J, Shimizu H, Takeuchi I, Hagiwara SI, Mizuochi T, Takaki Y, Ishige T, Nishizawa T, Kudo T, Ito N, Kawai Y, Kakuta Y, Nagasaki M, Shimizu T, Iwama I, Arai K•
PubMed

Two Cases of Allergic Contact Dermatitis Caused by Coco Betaine in Clobetasol Propionate Shampoo.

We present two cases of allergic contact dermatitis caused by the amphoteric surfactant coco betaine, a constituent of clobetasol propionate (CP) shampoo, despite the low allergenic potential of CP shampoo formulations. The patients were Japanese males, aged 49 and 52 years, with severe atopic dermatitis, who had been treated with oral cyclosporine for several years. Patch testing revealed that only coco betaine 1% aq. showed a clearly positive reaction in both cases, whereas the patch test resu...

Articles
Iijima S, Murayama K, Takayama N, Sugiyama M, Matsunaga K•
PubMed

Challenges With Buprenorphine Initiation in the Fentanyl Era-Adapting Effectively to the Moment.

Current best practice for management of opioid use disorder (OUD) includes provision of medication with full (eg, methadone) or partial (eg, buprenorphine) activity at the μ opioid receptors. Buprenorphine is extensively used to treat OUD, and has long been noted to have the capacity to precipitate opioid withdrawal with initial dosing.1 In this study, Kawasaki et al2 share data from a nationwide survey of buprenorphine prescribers reporting challenges with buprenorphine-related withdrawal in th...

Articles
Garneau WM, Strain EC, Fingerhood MI•
PubMed

Adult reference values for spirometry, body plethysmography and diffusing capacity adjusted for sex, age, weight, height or arm span - the Danish lung function material (DALFUMAT) study.

ABSTRACT Objectives The study aimed to develop new national reference values for dynamic and static lung volumes, as well as diffusing capacity for carbon monoxide, measured in the same participants. These values were compared with existing reference values from GLI and ECCS. Additional aims included the development of lung function reference values based on arm span, the establishment of post-bronchodilator reference values for spirometry, the creation of reference values for bronchodilator r...

Articles
Mortensen J, Kristensen L, Munkholm M, Hanel B, Abrahamsen J, Sidenius K, Grønlund B, Hilberg O, Maltbæk N, Titlestad IL, Dahl R, Bibby BM, Kryger SN, Weinreich UM, Schmid JM, Bendstrup E, Paludan JPD, Hyldgaard C, Danielsen LM, Dahl LS, Jørgensen E, Jensen TT, Ellingsgaard TK, Fuglø D, Hovind P, Berg RMG, Madsen F•
PubMed

Significance of 14-3-3 Epsilon for Right Ventricular Failure Associated with Pulmonary Hypertension.

Objective The pathophysiology of right ventricular failure in patients with pulmonary hypertension has not been completely examined and monitoring strategies are lacking. The 14-3-3 protein family plays a regulatory role in cardiac fibroblasts. This study investigated whether 14-3-3 epsilon, a member of the 14-3-3 protein family, was associated with right ventricular failure. Methods A monocrotaline-induced pulmonary hypertension rat model was used to investigate the role of 14-3-3 epsilon in...

Articles
Yokokawa T, Nishiura K, Akama J, Kiko T, Sato Y, Miura S, Sato A, Shimizu T, Misaka T, Sato T, Oikawa M, Yoshihisa A, Sugimoto K, Nakazato K, Takeishi Y•
PubMed

Transcutaneous Auricular Vagus Nerve Stimulation Alleviates Headache Symptoms in Migraine Model Mice by the Locus Coeruleus/Noradrenergic System: An Experimental Study in a Mouse Model of Migraine.

Background/Objectives: Migraine is a complex neurological headache disorder, and transcutaneous auricular vagus nerve stimulation (taVNS) can effectively relieve headache symptoms, but its mechanism of effect is still unclear. This study aimed to explore the regulatory effects of taVNS on the locus coeruleus (LC) and the norepinephrine (NE) system in migraine mice. Methods: C57/BL6 mice were randomly assigned to four experimental groups: the control group, model group, taVNS group, and sham taVN...

Articles
Song X, Chen Z, Zhu H, Rong P, Zhang J, Pu X, Wang J•
PubMed

The Serine Protease-Serine Protease Inhibitor Regulatory Network in Inflammatory Bowel Disease: From Molecular Mechanisms to Novel Therapeutic Horizons.

Background Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that presents a significant global health challenge. Although its exact etiology remains unclear, growing evidence indicates that dysregulation of the complex regulatory network of serine proteases and their inhibitors is a major contributor to IBD pathogenesis. This imbalance leads to both pro-inflammatory and protective effects within the inflamed intestine, highlighting the need to be...

Articles
Li Q, Ye H, Chen R, Zhou G, Zhang S•
PubMed

Prevalence and Patterns of Cardiac Arrhythmias in Patients With Chronic Kidney Disease Undergoing Hemodialysis: A Retrospective Study.

Background Cardiac arrhythmias are a leading cause of morbidity and mortality among patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis. Objective The objective of the study is to determine the prevalence and patterns of cardiac arrhythmias in CKD patients receiving maintenance hemodialysis and to identify clinical and dialysis-related factors associated with arrhythmia occurrence. Methods This retrospective cross-sectional study was conducted at Sir Ganga Ram Hos...

Articles
Yousaf MH, Abbas H, Shahzad F, Altaf A, Riaz S, Obaid M, Qureshi DR•
CDC

Diabetes Basics

Diabetes is a long-lasting health condition that affects how your body turns food into energy.

Articles
PubMed

The Traditional Chinese Medicine Compound Hezi Qingyou Formula Controls the MAPK Signaling Pathway for Alleviating Gastric Ulcer Induced by Acetic Acid in Rats.

In clinical practice, Hezi Qingyou Formula (HZQYF) has been observed to effectively alleviate clinical symptoms associated with gastri ulcers, though its precise mechanism of action remains unclear. To investigate the effects of HZQYF on gastric ulcers, we established a rat model of gastric ulcer and examined its impact on ulcer area, pathological changes, inflammatory cytokines, gastric repair factors, levels of T‐superoxide dismutase (SOD), and malondialdehyde (MDA), as well as metabolites in...

Articles
Feng Z, Wei R, Tian J, Li H, Chen H, Hao Y, Chen M, Su B, Lai Y, Xun M, Zhang G, Yao M•
PubMed

Microvascular endothelial metabolic dysfunction drives cerebral edema through bioenergetic failure after ischemia-reperfusion.

Aim: Despite major advances in recanalization therapy, poor functional outcomes after ischemic stroke remain common. The central challenge is not only restoring blood flow but also overcoming the bioenergetic failure that can persist during reperfusion. This study aims to identify the missing link by defining how a metabolic-epigenetic cascade drives microvascular energetic collapse, thereby elucidating mechanisms underlying sustained cerebral edema and the no-reflow phenomenon following ischemi...

Articles
Zhou YF, Yang SB, Zhang F, Sun XD, Chang BH, Li YN, Wu JH, Jin HJ, Huang M, Chen SC, Yang H, Zhu DY, Menon BK, Hu B•