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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,813–1,824 of 2,098 articles

PubMed

Effectiveness of Superior Laryngeal Nerve Block in Patients with Neurogenic Cough: A Prospective Cohort Study.

Introduction: A study was undertaken to evaluate the role of superior laryngeal nerve block in management of neurogenic cough. Materials and Methods: A Prospective Cohort study was conducted on 30 patients of neurogenic cough in Government Medical College, Patiala, India from Jan 2024 to May 2025. Adult patients with unexplained cough > 8wks were included in the study and superior laryngeal nerve block with long acting steroid and local anaesthetic was given. All patients were monitored every...

Articles
Kaur J, Yadav V•
PubMed

Milk Components and Fatty Acid Composition as Predictors of Days Open in Early Lactation Holstein Cows.

ABSTRACT This study investigated relationships between milk components, fatty acid (FA) composition, and days open in early lactation Holstein cows under heat stress and non‐heat stress conditions, and evaluated predictive ability for reproductive performance. Data from 461 multiparous cows (1155 observations) across three farms were analyzed using dairy herd improvement (DHI) records from March 2020 to September 2024. Cows were classified by days open (≤ 150 vs. ≥151 days) and season, and anal...

Articles
Nagahaka N, Matamura M, Kondo M•
PubMed

Omalizumab as an Effective Therapy for Testosterone-induced Angioedema in a Transgender Person: A Case Report.

Background Gender affirming hormone therapy is a cornerstone for transgender and gender diverse individuals. We report the first case in the literature of systemic allergic reactions to testosterone therapy and how we succeeded in managing them. Case Presentation A 19-year-old transgender person assigned female at birth started testosterone therapy to achieve full masculinization. For 14 months, testosterone was administered via transdermal and intramuscular preparations and was well tolerate...

Articles
Marinelli L, Motta G, Castella L, Voltolini S, Romano A, Giudice AD•
PubMed

Single-Cell RNA Sequencing Revealing Dysregulated Perturbations of Tregs in Psoriasis and Construction of a Treg-Related Diagnostic Model via a 101- Combination Machine Learning Computational Framework.

Introduction Regulatory T cells (Tregs) exhibit compromised immunosuppressive functions in psoriasis, yet understanding of their dysregulated perturbations remains limited. Methods scRNA-seq data from the skin of patients with psoriasis and healthy controls were analyzed to identify emigrating cells and their populations and functional states. Pseudotime as well as cell-cell communication analyses were employed to explore the origins and interactions of psoriasis-related Tregs. hdWGCNA, LASSO...

Articles
Huang Z, Sui Y, Liu S•
PubMed

The Heart of Psoriasis: Cardiovascular Alterations and Common Inflammatory Mechanisms.

Introduction This mini-review aims to investigate the shared pathophysiological mechanisms linking psoriasis to cardiovascular disease (CVD), with a particular emphasis on electrocardiographic and echocardiographic alterations in individuals affected by psoriasis. Methods A comprehensive search of PubMed and Google Scholar was conducted for studies published between January 1980 and June 2025. The search included clinical trials, observational studies, reviews, and meta-analyses. Results Th...

Articles
Santillo E, Marini L, Cardinali L•
PubMed

Mendelian Randomization Analysis of Psoriasis and Multiparameter Renal Function Trajectories.

Introduction While observational studies suggest that psoriasis may increase the risk of renal impairment, evidence supporting a causal relationship remains inconclusive. This Mendelian randomization (MR) study systematically investigates the genetic causality between psoriasis and multidimensional renal function trajectories, encompassing both static measures and dynamic progression patterns. Methods We utilized genetic variants associated with psoriasis identified in a Finnish population-ba...

Articles
Huang Z, Liu S•
PubMed

CD20 Loss as a Mechanism of Resistance to Mosunetuzumab in Relapsed Follicular Lymphoma.

To the editor. Mosunetuzumab (mosu), a CD20×CD3 bispecific antibody, has emerged as an effective therapeutic option for relapsed/refractory (R/R) follicular lymphoma (FL), yielding durable remissions even in heavily pretreated patients. In the pivotal phase II GO29781 study, mosu achieved substantial clinical activity and subsequently received accelerated approval in this setting. Updated analyses confirmed its long-term benefit, with complete remission (CR) rates approaching 60% and a 2-year p...

Articles
Canichella M, Fratoni S, Mazzone C, Di Rocco A, Abruzzese E•
PubMed

Commentary on Seersholm Et al.: Yersinia pestis Infection Is Not Synonymous With Deadly Plague in Neolithic Scandinavia.

ABSTRACT Objectives Emerging genomic evidence has identified ancestral strains of Yersinia pestis in ancient human populations, which has sparked debates about its pathogenic role in later Neolithic societies. Here, we review published evidence linking anthropological and biological data reflecting the past natural history of Y. pestis infection. Materials and Methods Review of reported ancient Y. pestis genomes, paleomicrobiological, archaeological, and ecological data related to ancient pl...

Articles
Oumarou Hama H, Drancourt M, Slavin P, Sebbane F•
PubMed

Genomic Characterization of an Emergent Cross-Border Recombinant Duck Plague Virus With High Pathogenicity and Reduced Vaccine Efficacy in Guangxi, China.

Duck plague virus (DPV) is a major pathogen causing recurrent outbreaks in waterfowl. This study reports the comprehensive characterization of a novel DPV strain, designated GXGG240520, isolated from clinically diseased ducks in Guangxi, China. The strain was confirmed as a virulent DPV by PCR targeting the UL2 gene (1002 bp) and exclusion of other common duck pathogens. In pathogenicity tests, ducks challenged with GXGG240520 exhibited severe clinical signs including anorexia, diarrhea, and hem...

Articles
Yang S, Xu S, Wang K, Liu C, Yang H, Yuan L, Ma S, Xie H, Zhang Z, Li G, Si H, Ning K, Ou C•
PubMed

Mechanism of Buzhong Yiqi Decoction Modulates the Wnt5a/β-catenin Signaling Pathway to Ameliorate Thyroid Inflammatory Damage in Mice with Autoimmune Thyroiditis.

Introduction The Objective is to explore the mechanism by which Buzhong Yiqi decoction improves inflammatory damage in autoimmune thyroiditis (AIT) mice based on the Wnt5a/β-catenin signaling pathway. Methods Sixty 8-week-old NOD.H-2h4 mice of SPF grade were selected and randomly divided into six groups: control group, model group, Buzhong Yiqi decoction low, middle, and high-dose groups (4.78, 9.56, 19.12 g·kg-1), and Western medicine group (selenium yeast tablets, 3.033×10-5 g·kg-1), with t...

Articles
Gao H, Liu Z, Zhao Z, Li J, Wang Z, Cao H, Chen Y, Chen S, Jin Z, Yang X•
PubMed

Exploring Causal Links Between 91 Circulating Inflammatory Proteins and Hashimoto's Thyroiditis: A Bidirectional Mendelian Randomization Study.

Background Increasing evidence has linked inflammation to Hashimoto’s thyroiditis (HT) etiology. However, the causal role of circulating inflammatory proteins in HT remains uncertain. To investigate this, we conducted a bidirectional Mendelian randomization (MR) study. Methods Genetic data for 91 inflammatory proteins and HT were sourced from publicly available GWAS databases. The PhenoScanner database was then searched for pleiotropic SNPs associated with potential confounders. Inverse varia...

Articles
Ding S, Su W, Wu M, Fu M, Wang M, Ji H, Yang B, Zhang Z, Ma C, Pan J, Di X, Zhang X, Zhao X, Sun X, Kong Y•
PubMed

Severe adrenal insufficiency coexisting with autoimmune thyroiditis (Schmidt's syndrome) - case report.

We present a case report of a 14-year-old girl with Schmidt’s syndrome, also known as autoimmune polyglandular syndrome type 2. The previously healthy child began experiencing symptoms including weight loss, nausea, abdominal pain, and poor exercise tolerance. Symptoms worsened during infections, resulting in multiple hospitalisations at a district hospital. During one hospitalisation, autoimmune thyroiditis was diagnosed, and levothyroxine therapy was initiated. After starting levothyroxine tre...

Articles
Dubas K, Flader M, Niedziela M•