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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,825–1,836 of 2,098 articles

PubMed

Buzhong Yiqi Decoction Regulates Th17 Cells Differentiation in Autoimmune Thyroiditis through PTEN/AKT-immunometabolism Axis.

Introduction Autoimmune thyroiditis (AIT), a prevalent autoimmune disorder, can severely impair patients' quality of life when progressing to hypothyroidism. This investigation seeks to systematically evaluate the therapeutic efficacy of Buzhong Yiqi Decoction (BZYQ) against iodine-induced AIT while elucidating its underlying molecular mechanisms. Methods NOD.H-2h4 mice received daily 0.05% sodium iodide gavage for 8 weeks to induce AIT. Thyroid histopathology was evaluated by HE staining. Se...

Articles
Li J, Zhao Z, Liu D, Luo Y, Guo FY, Wang ZM, Song N, Liu Z, Yang X•
PubMed

Triglyceride Glycemic Index and Triglyceride/HDL Ratio: Can They be Biomarkers for Insulin Resistance in Euthyroid Women with Hashimoto's Thyroiditis, and Are They Related to Thyroid Function Tests?

Introduction Hashimoto’s thyroiditis (HT) is the most common autoimmune disease. Insulin resistance (IR), independent of thyroid function tests but attributed to thyroid autoantibodies, can be observed in (HT). The most frequently employed method for demonstrating IR is the HOMA-IR index. Recently, the triglyceride-glucose index (TGI) and triglyceride-to-HDL ratio (TG/HDL) have been proposed as novel, practical, and cost-effective indicators of IR. Thus, this study aimed to investigate the rela...

Articles
ÇetinkayaAltuntaş S, Özgen H•
PubMed

Anti-TNF Drug-Induced Sarcoidosis in Inflammatory Bowel Diseases: Multicentric Case Series and Literature Review.

Introduction Sarcoidosis is an inflammatory granulomatous condition and presents overlapping features with inflammatory bowel disease (IBD). Anti‐TNF treatment has revolutionized the management of several conditions, including IBD and sarcoidosis. Yet, anti‐TNF drugs have been associated with drug‐induced sarcoidosis reaction (DISR). Methods This is a retrospective, international, multicentric case series, including IBD patients with anti‐TNF–related DISR. A literature review was performed to...

Articles
Bez P, Chkolnaia Z, Aratari A, Ascolani M, Bacsur P, Blesl A, Seksik P, Nikolic S, Edoardo V S, Rattazzi M, Cinetto F, Felice C•
PubMed

Integrated Bioinformatics Methods Were Employed to Investigate Potential Molecular Links Between Obstructive Sleep Apnea and Sarcoidosis.

Background Previous studies have established a frequent coexistence of obstructive sleep apnea (OSA) and sarcoidosis, yet the molecular mechanisms linking these conditions are not well understood. Methods This study employed integrated bioinformatics analysis and Mendelian randomization (MR) to identify potential mechanisms and infer causal relationships between OSA and sarcoidosis. Genetic instruments associated with OSA and sarcoidosis were screened, and bidirectional MR analysis was conduc...

Articles
Li Y, Lan C, Lei H, Lyu Z, Lin D, Shen J, Jiang H, Wang Y, Lu C, Liu Y•
PubMed

Paraneoplastic Pemphigus Mimicking Stevens-Johnson Syndrome in a Patient with Multiple Myeloma: A Rare and Clinically Challenging Presentation.

Paraneoplastic pemphigus (PNP) is a rare, severe autoimmune mucocutaneous disorder most commonly associated with lymphoproliferative malignancies. Here, we report the first documented case of PNP as a paraneoplastic manifestation of multiple myeloma (MM). A 61-year-old male with MM developed widespread mucocutaneous ulcerations shortly after his eleventh chemotherapy cycle, initially suspected to represent Stevens–Johnson syndrome. Clinical examination revealed diffuse skin peeling, mucosal invo...

Articles
Keshavarz Z, Zangooie A, Sadooghi Rad E, Bojaran R, Salehi Z•
PubMed

Aberrant Glymphatic System Function in Chronic Heart Failure with Preserved Ejection Fraction.

Background Cognitive dysfunction is frequently observed in chronic Heart Failure with preserved Ejection Fraction (HFpEF) patients, while the underlying neuropathological basis remains incompletely characterized. This study aimed to demonstrate aberrant glymphatic system function in chronic HFpEF and its association with cognitive ability. Materials and Methods We proposed a multimodal neuroimaging model combining the Analysis of Perivascular Space Index (ALPS-index), Choroid Plexus Volume (C...

Articles
You J, Sheng Z, Xia Y, Zhang Y, Xing C, Chen H, Chen YC, Qian J, Yin X•
PubMed

Exercise as a complementary intervention for adults with attention deficit hyperactivity disorder: a neurobiological analysis.

Objective Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention and/or hyperactivity–impulsivity that interferes with functioning or development. Stimulant medication remains its first-line treatment, but perceived ineffectiveness, side effects, and lack of treatment access may pose challenges for adults with ADHD. Physical exercise has received increasing attention in the treatment of children with ADHD, but research in adults...

Articles
Im D•
PubMed

Hydroxychloroquine Prevents High-altitude Cerebral Edema by Inhibiting Endothelial Claudin-5 Autophagic Degradation.

Background High-altitude cerebral edema (HACE) is a serious condition caused by prolonged hypobaric hypoxia (HH). Autophagic degradation of Claudin-5 plays a crucial role in HH-induced blood-brain barrier (BBB) damage. Hydroxychloroquine (HCQ), a lysosomal inhibitor used in autophagy treatment, reduces inflammation and BBB damage in traumatic brain injury. However, its effectiveness in preventing HACE is still unknown. Methods C57BL/6J mice were treated with HCQ and exposed to HH for 24 hrs t...

Articles
Xue Y, Wan B, Wang Z, Wang Z, Wang D, Yang W, Wang X, Zhu L•
PubMed

RETRACTION: Apelin-13 Is an Early Promoter of Cytoskeleton and Tight Junction in Diabetic Macular Edema via PI-3K/Akt and MAPK/Erk Signaling Pathways.

RETRACTION: Y. Li, Y‐J. Bai, Y‐R. Jiang, W‐Z. Yu, X. Shi, L. Chen, J. Feng, G‐B. Sun, “Apelin‐13 Is an Early Promoter of Cytoskeleton and Tight Junction in Diabetic Macular Edema via PI‐3K/Akt and MAPK/Erk Signaling Pathways,” BioMed Research International, 2018, 3242574, https://doi.org/10.1155/2018/3242574 The above article, published online on 04 April 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Dr. Yoel A. Klug;...

Articles
Research International B•
PubMed

A Network Biology Framework for Exploring Molecular Mechanisms in Cystoid Macular Edema.

Objectives To explore the molecular mechanisms underlying cystoid macular edema (CME) through protein-protein interaction (PPI) network analysis, identifying key regulatory proteins, functional modules, and enriched biological pathways relevant to its pathogenesis. Methods A curated list of 18 CME-associated human proteins was compiled through a literature review, including inflammatory cytokines, angiogenic factors, and regulators of vascular permeability. High-confidence PPI data were obtai...

Articles
Shariati MM•
PubMed

Preoperative Prediction of Fat-Suppressed T2-Weighted Imaging-based Breast Edema Scores for Lymphovascular Invasion in Patients with Breast Cancer.

Introduction: Lymphovascular invasion (LVI) is a critical prognostic factor in breast cancer, typically diagnosed via postoperative pathology. This study aimed to evaluate whether fat-suppressed T2-weighted imaging (FS T2WI)-based breast edema score (BES) combined with clinicopathological features could preoperatively predict LVI status. Materials and Methods: This retrospective study enrolled 574 breast cancer patients who underwent MRI and surgery from January 2021 to December 2023. Patient...

Articles
Sun R, Wang X, Hu Y, Huang Z, Liu H, Wang X•
PubMed

Isfahan familial hypercholesterolemia cohort (IFHC) study: Methods, insights and early results.

BACKGROUND: Familial hypercholesterolemia (FH) is the most common monogenic disorder in humans. There is a lack of data on the clinical characteristics and natural history of FH patients in Iran, which necessitates performing a longitudinal study. METHODS: In this five-year prospective longitudinal cohort study, we enrolled patients with high LDL cholesterol who were registered in the Iranian Registry of Hypercholesterolemia (IFHR), diagnosed as definite and probable FH cases based on the Dut...

Articles
Zarfeshani S, Vaseghi G, Mohammadifard N, Dianatkhah M, Najafian J, Shekarchizadeh M, Hajian S, Pourmoghaddas A, Vaseghi A, Khosravi E, Sarrafzadegan N, Heshmat Ghahderijani K•