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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 301–312 of 2,098 articles

PubMed

Effects of Lovastatin on Autism-Like Behavioral, Metabolic, and Neuroinflammatory Alterations in Male BTBR T+ Tf/J Mice.

Introduction Statins inhibit 3-hydroxy-3-methylglutaryl–coenzyme A (HMG-CoA) reductase, thereby reducing cellular cholesterol and isoprenoid biosynthesis. In addition to lowering serum cholesterol, statins exert pleiotropic neuroprotective effects, including anti-inflammatory, antioxidant, and immunomodulatory actions mediated through the mevalonate pathway. Statins are increasingly being explored for drug repurposing in neuropsychiatric and neurodevelopmental disorders. This study evaluated th...

Articles
Jayaprakash P, Thomas SD, Salleh H, Abdullah H, Al Dhaheri D, Baniyas S, Al Derei M, Al Rahbi F, AlKaabi A, Al Shamsi N, Al Houqani S, Oz M, Sadek B•
PubMed

Serum CCL23 as a Potential Biomarker for Asthma in Pregnancy: A Prospective Case-Control Study.

Purpose Early identification of asthma in pregnancy is challenging due to limited feasibility of pulmonary function testing. We aimed to characterize serum CCL23 expression in pregnant women with asthma and to assess its potential as an auxiliary clinical marker. Methods Transcriptomic sequencing first identified differentially expressed genes (DEGs) in peripheral blood between pregnant women with asthma and healthy pregnant controls. A validation cohort of 37 pregnant women with asthma and 3...

Articles
Xie J, Yan X, Song Y, Wang H, Xu G, Xu L•
PubMed

Reviewed article: Carvalho, SMO; Andrade, JX; Nascimento, FF; Rodrigues, MTP; Mascarenhas, MDM. Temporal trends in acquired syphilis detection, hospitalizations, and mortality: a time series analysis, Brazil, 2011-2023. Epidemiol Serv Saude. 2026:35;e20251388.

Peer review A Questionnaire Does the manuscript contain new and significant information to justify publication? Yes Does the Abstract (Summary) clearly and accurately describe the content of the article? Yes Is the problem significant and concisely stated? Yes Are the methods described comprehensively? Yes Are the interpretations and conclusions justified by the results? Yes Is adequate reference made to other work in the field? Yes Manuscript Structure: Length of article is: Adequate...

Articles
Eduvirgem J•
PubMed

Reviewed article: Carvalho, SMO; Andrade, JX; Nascimento, FF; Rodrigues, MTP; Mascarenhas, MDM. Temporal trends in acquired syphilis detection, hospitalizations, and mortality: a time series analysis, Brazil, 2011-2023. Epidemol Serv Saude. 2026:35;e20251388.

Peer review B Questionnaire Does the manuscript contain new and significant information to justify publication? Yes Does the Abstract (Summary) clearly and accurately describe the content of the article? Yes Is the problem significant and concisely stated? Yes Are the methods described comprehensively? No Are the interpretations and conclusions justified by the results? Yes Is adequate reference made to other work in the field? Yes Manuscript Structure: Length of article is: Adequate N...

Articles
de Sousa IBA•
PubMed

Reviewed article: Carvalho, SMO; Andrade, JX; Nascimento, FF; Rodrigues, MTP; Mascarenhas, MDM. Temporal trends in acquired syphilis detection, hospitalizations, and mortality: a time series analysis, Brazil, 2011-2023. Epidemol Serv Saude. 2026:35;e20251388.

First round comments Agradecemos a submissão do manuscrito RESS-2026-1388 intitulado “Tendência temporal da detecção, internação hospitalar e mortalidade da sífilis adquirida, Brasil, 2011-2023: estudo de série temporal” à Revista Epidemiologia e Serviços de Saúde: revista do SUS (RESS). Após a revisão do seu artigo, identificamos a necessidade de uma revisão substancial para que o manuscrito esteja de acordo com os padrões editoriais da revista e para viabilizar sua publicação. Além dos pont...

Articles
Moura MDG•
PLOS

Fungal suppression by bacterial metabolite-activated human intestinal γδT-cells is disrupted in Crohn’s disease

Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacterial metabolite HMB-PP is sensed by a specialized population of Vγ9Vδ2+T-cells, which we now report can potently suppress growth of endogenous fungi in human intestinal organ cultures. In healthy intestine, HMB-PP-stimulated Vδ2+ T-cells restricted outgrowth of keystone fungus Candida albicans via a...

Articles
Liya Mathew, Sean L. Carlson, Michael Savage, Claire Pardieu, Megan B. O’Brien, Ellie Crawley, Paul Harrow, Ann-Kristin Kaune, Edward Devlin, Emily L. Priest, Marilena Crescente, Kimberly Martinod, James Boot, SoFong Cam Ngan, Marco Gasparetto, Klaartje Kok, James O. Lindsay, Jonathan P. Richardson, Julian R. Naglik, Andrew J. Stagg, Matthias Eberl, Siu Kwan Sze, Carol A. Munro, Neil E. McCarthy•
PLOS

A mucosal barrier injury related six gene transcriptomic signature associated with ulcerative colitis using machine learning and public transcriptomic data

Ulcerative colitis (UC) is characterized by epithelial barrier disruption, mucosal immune activation, and sustained intestinal inflammation. We developed a biologically interpretable public-transcriptomic signature using Gene Expression Omnibus datasets GSE75214, GSE38713, and GSE92415. A literature-curated panel of 35 mucosal barrier injury-related genes was integrated with differential expression, LASSO regression, random forest prioritization, and ridge logistic regression. Six genes (LCN2, D...

Articles
Sen He, Pingliang Sun, Xiaoxin Duan•
PLOS

Online co-care management and glycemic control in patients with type 2 diabetes mellitus: A propensity score-matched retrospective cohort study

Objective: This study aimed to investigate the association of an Online Co-care Management (OCCM) model with changes in glycemic control and metabolic indicators among patients with type 2 diabetes mellitus (T2DM). Methods: Based on clinical follow-up records, we conducted a retrospective cohort study with a propensity score (PS)-matched control group.The OCCM group included patients enrolled in the integrated care clinic from 2022 to 2025 (n = 406). Among patients who did not participate in OCC...

Articles
Shujuan Sun, Ge Yang, Hao Tong, Hui Zhao, Qin Liu, Yiran He, Zhiyue Zhang•
PLOS

Bacterial urinary tract infections and urogenital schistosomiasis co-infection among primary school children in a Meatu district, Tanzania: A call for an integrated preventive approach

Background: Urogenital schistosomiasis (UGS) remains a significant public health issue in Tanzania, co-infection with urinary tract infections (UTIs) can complicate diagnosis due to overlapping symptoms. Additionally, gastrointestinal carriage of multidrug-resistant bacteria (MDRB) increases risks of self-infection and transmission to others. Primary school-aged children in rural settings are particularly at risk for both diseases due to poor water sanitation and risky behaviors. This study repo...

Articles
Johannes Rukyaa, Prisca Damiano, Vitus Silago, Domenica Morona, Jeremiah Seni, Humphrey D. Mazigo, Stephen E. Mshana•
PLOS

Enhancing pathogen detection in pediatric diarrheal stools: The case of molecular multiplexing with a real-time PCR assay

Diarrhea is a leading cause of pediatric morbidity and mortality worldwide, frequently caused by various bacterial, viral, and protozoan pathogens. Identification of these pathogens is important in clinical settings for proper management of the infection. Conventional stool culture technique is time-consuming for the detection of diarrheagenic pathogens. In addition, these traditional procedures lack sensitivity, require a specific laboratory structure, and well-trained staff. Conversely, multip...

Articles
Goutam Chowdhury, Melissa Glenda Lewis, Alok Deb, Mamta Chawla-Sarkar, Sandipan Ganguly, Paulami Dutta, Santasabuj Das, Asish K. Mukhopadhyay, Thandavarayan Ramamurthy•
PLOS

Compare 30-minute automated office blood pressure vs 24-hour ambulatory blood pressure monitoring: A prospective study

Background: Ambulatory blood pressure monitoring (ABPM) is the reference standard for diagnosing hypertension (HTN), but its use in routine practice remains limited because of cost, availability, and patient burden. Automated office blood pressure (AOBP) has been proposed as a practical alternative, although its performance relative to ABPM remains uncertain. Objectives: To evaluate the agreement and diagnostic performance of 30-minute AOBP compared with 24-hour ABPM and to identify optimal cut-...

Articles
Ai Cao My Bui, Quynh Tran Nhat Nguyen, Anh Ngoc Minh Bui, Minh Vu Phuc Ha, Nhan Phu Nguyen, Thy Ha Anh Nguyen, Nhan Quoc Dang, Phuong Minh Tran, Tu Vu Kha, Nhu Dong Phuong Nguyen, Liem Diep Bao Le, Huy Hoai Tran, Dung The Bui, Nghia Phu Nguyen•
PLOS

Prevalence, associations and sex-related disparities of hypertension in South Asians: Evidence from a national survey of Sri Lanka

Background: Blood pressure(BP) control remains suboptimal worldwide. Sex-related disparities in hypertension have been reported, but data from South Asia are limited. Understanding the epidemiology and sex-related differences is essential to improve BP control. Objectives: To assess the prevalence, associations and sex-related disparities of hypertension among Sri Lankans. Methods: We analysed secondary data from the Sri Lanka STEPS Survey 2021, a nationally representative, community-based, cros...

Articles
Chamila Mettananda, Ravini Premaratna, Randula Mallawa, Upeksha Fernando, Arundika Senaratne, Udara Perera, Champika Wickramasinghe•