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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 313–324 of 2,098 articles

PLOS

Female sexual dysfunction in premenopausal women with diabetes mellitus in northern Nigeria: A cross-sectional study from two tertiary hospitals examining associations with glycaemic control and reproductive hormones

Background: Female sexual dysfunction (FSD) is a recognised complication of diabetes mellitus (DM), but evidence on its clinical and biological correlates in sub-Saharan Africa remains limited. FSD is defined as a disorder characterized by disturbances in sexual desire, arousal, orgasm, and/or pain that causes interpersonal difficulty or distress. This study examined associations between glycaemic control, reproductive hormonal status, and FSD among premenopausal women with diabetes in northern...

Articles
Fatima M. Damagum, Amina H. Hassan, Andrew E. Uloko, Hauwa A. Habeeb, Hadiza B. Damagum, Zainab A. Umar, Hassan A. Murtala, Zainab Abdulkadir, Ibrahim Y. Ibrahim, Zainab U. Ibrahim, Umar F. Abdullahi, Hamisu M. Salihu, Muktar H. Aliyu, Phylis J. Kanki, Baba M. Musa•
PubMed

Temporal trends in acquired syphilis detection, hospitalizations, and mortality: a time series analysis, Brazil, 2011-2023.

Resumo Objetivo: Analisar a tendência temporal de detecção, internação hospitalar e mortalidade da sífilis adquirida no Brasil no período de 2011 a 2023. Métodos: Análise de série temporal, com dados secundários do Sistema de Informação de Agravos de Notificação, do Sistema de Informações Hospitalares do Sistema Único de Saúde e do Sistema de Informações sobre Mortalidade. Foram calculadas as taxas de detecção, internação hospitalar e mortalidade segundo região geográfica. Foi utilizado o mo...

Articles
de Carvalho SMO, Andrade JX, Nascimento FF, Rodrigues MTP, Mascarenhas MDM•
PubMed

Integrated Transcriptomic and DNA Methylation Analysis Identifies KRT6B and CHI3L2 as Candidate Shared Biomarkers of Psoriasis and Cutaneous Melanoma.

Background Different studies have drawn inconsistent conclusions on whether psoriasis increases the risk of cutaneous melanoma (CM). Although shared gene expression or methylation pathways between the two diseases have been independently reported, suggesting a potential molecular basis for their comorbidity, whether expression and methylation synergistically contribute to their pathogenesis remains unclear. Therefore, this study aimed to identify common methylation-regulated genes (co-MRGs) as...

Articles
Gao L, RenChen X, Li H, Li B•
PubMed

Persistent hypogammaglobulinaemia after rituximab in children with difficult-to-treat nephrotic syndrome: a multicentre cross-sectional observational study.

Background Rituximab is widely used for difficult steroid-dependent and frequently relapsing nephrotic syndrome (SDNS/FRNS). Persistent hypogammaglobulinaemia (PH) after rituximab is increasingly recognised, but data from low- and middle-income settings remain limited. Methods In this multicentre cross-sectional study, children <18 years with SDNS/FRNS who had received rituximab ≥12 months earlier were evaluated for serum immunoglobulin G (IgG) levels. PH was defined as IgG<2 SD below age-adj...

Articles
Saha S, Baranwal D, Sarkar S, Poddar S, Akhtar S, Tse Y, Sinha R•
PubMed

Low-Titre ANA Late-Onset Systemic Lupus Erythematosus Presenting With Pleural Effusion and Markedly Elevated Pleural Adenosine Deaminase Mimicking Tuberculous Pleuritis.

ABSTRACT Pleural effusion with markedly elevated adenosine deaminase (ADA) levels is commonly associated with tuberculous pleuritis but may occur in other conditions. We report a case of low‐titre ANA late‐onset systemic lupus erythematosus (SLE) presenting with pleural effusion and markedly elevated ADA levels mimicking tuberculosis. A 78‐year‐old man with pneumoconiosis presented with fever, cough, and progressive pleural effusion. Pleural fluid analysis revealed lymphocyte‐predominant exudat...

Articles
Inoue S, Tatsuta M, Tatsutani T, Ueda S, Wakamatsu K, Kawasaki M•
PubMed

Early decline in anti-integrin αvβ6 autoantibodies strongly predicts 1-year clinical remission in vedolizumab-treated patients with ulcerative colitis.

Abstract Background Anti-integrin αvβ6 immunoglobulin G autoantibodies have emerged as one of the most accurate non-invasive biomarkers for ulcerative colitis (UC). We aimed to validate their diagnostic performance in a French multicentre cohort of patients with inflammatory bowel disease (IBD) and to evaluate their predictive value for vedolizumab clinical response. Methods We performed a multicentre, non-interventional post hoc analysis using prospectively collected serum samples and clini...

Articles
Roblin X, Mechi F, Berger AE, Fumery M, Nancey S, Hébuterne X, Carbonnel F, Altwegg R, Barrau M, Sparrow MP, Duru G, Paul S•
PubMed

Selective Electrical Muscle Stimulation of the Vastus Medialis in a Patient With Knee Osteoarthritis, With Changes in Muscle Quality, Symptoms, and Physical Activity: A Case Report.

Patient: Male, 77-year-old Final Diagnosis: Osteoarthritis of the knee Symptoms: Decrease in physical activity • knee joint pain Clinical Procedure: — Specialty: Rehabilitation Objective: Unusual or unexpected effect of treatment Background Fat accumulation in the vastus medialis has been associated with the progression of knee osteoarthritis. Electrical muscle stimulation may reduce intramuscular fat accumulation by inducing contractions of the targeted muscle. We hypothesized that elect...

Articles
Tanino Y, Fukumoto Y, Kono T, Yoshida T•
PubMed

Gut Microbiota Signaling Axes as Candidate Therapeutic Targets in Type 2 Diabetes Mellitus: Mechanistic Crosstalk and Translational Challenges.

Abstract Gut microbiota disturbance serves as a critical pathogenic factor for metaflammation (metabolic inflammation) and insulin resistance in type 2 diabetes mellitus (T2DM). Growing preclinical evidence demonstrates that gut microbial metabolites modulate systemic metabolic and immune homeostasis via multiple interactive signaling axes rather than independent single pathways. This narrative review systematically summarizes four core signaling axes derived from gut microbiota. These axes inc...

Articles
Zhang Y, Zhang T, Tian Y, Wang H, Chen X•
PubMed

SGLT-2 Inhibitors versus GLP-1 Receptor Agonists for Dementia and Depression in Type 2 Diabetes Mellitus: A Meta-Analysis.

Background The comparative effects of sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and glucagon-like peptide-1 receptor agonists (GLP-1RA) on dementia and depression risk in patients with type 2 diabetes mellitus (T2DM) remain unclear. We conducted a meta-analysis to directly compare the incidence of dementia and depression-related outcomes between users of these two drug classes. Methods A systematic literature search was conducted across PubMed, Embase, Cochrane Library, and Web of S...

Articles
Pan R, Wang B, Li Y, Li H, Liang X, Zhang Y, Liu X, Huang X, Wang R, Ji H, Zhao Y•
PubMed

Non-thermal argon plasma therapy alleviates atopic dermatitis by reducing keratinocyte oxidative stress.

Atopic dermatitis (AD) is a prevalent inflammatory skin disorder associated with a considerable disease burden. Despite the advent of biologics a substantial unmet need remains for effective treatment. We aimed to evaluate the effects of non-thermal argon plasma (NAP) in patients with mild-to-moderate AD. The Eczema Area Severity Index (EASI), Numeric Rating Scale (NRS), and Dermatology Life Quality Index (DLQI) were evaluated following AD treatment. 16 S rRNA sequencing was used to assess alter...

Articles
Park YJ, Huang M, Lee YS, Kim HS, Kang HY, Kim CH•
PubMed

Dynamic CD4⁺ T-Cell eQTLs Reveal Gene Regulatory Networks Associated with Atopic Dermatitis.

Background and Objective Atopic dermatitis (AD) is a complex immune-mediated disorder in which aberrant activation of CD4⁺ T cells plays a critical pathogenic role. We integrated dynamic CD4⁺ T cell expression quantitative trait loci (eQTL) data with Mendelian randomization (MR) to dissect the causal effect of transcriptional changes on AD risk. Methods This study integrated dynamic CD4⁺ T-cell eQTL analysis, two-sample MR, colocalization analysis, single-cell transcriptomic, pseudotime, cell...

Articles
Chen J, Bai B•
PubMed

Bioactive Compounds from Traditional Chinese Medicine for Rheumatoid Arthritis: Exposure-Response Constraints, Causal Mechanisms, and Translational Evidence.

Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease sustained by synovial immune–stromal circuits and progressive osteoclast-mediated structural damage. This critical narrative review evaluates 15 chemically defined TCM-derived constituents selected because they have recurrent RA-relevant pharmacology together with sufficient mechanistic, exposure, safety, or translational evidence for comparative appraisal. English-language PubMed and Web of Science searches (January 2010–31 Ju...

Articles
Li H, Xie X, Li N•