Sign in Register

Clinical intelligence & editorial.

Advertisement

Advertisement

Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 325–336 of 2,098 articles

PubMed

Advanced Nanocarriers for Delivering Traditional Chinese Medicine Monomers in Rheumatoid Arthritis: Prospects and Challenges.

Abstract Rheumatoid arthritis (RA) is an auto-immune disease that is accompanied by constant inflammation and degradation of joints, causing disabilities and poor quality of life. Even though the available therapies alleviate symptoms, long-term use is often linked with loss of effectiveness, systemic toxicity, and poor patient compliance. Recently, bioactive monomers that can be extracted from Traditional Chinese Medicine (TCM) gained attention due to their anti-inflammatory, immunomodulating...

Articles
Yu H, He Z•
PubMed

Biosynthesis of selenium nanoparticles with orange peel waste in microwave: characterization, and spectral properties.

The objective of this study was to reuse agroindustrial waste from orange peels to obtain an orange peel aqueous extract (OPEa), used in the biosynthesis and characterization of selenium nanoparticles (SeNPs). The OPEa acted as a reducing and stabilizing agent in the synthesis of SeNPs, due to its polyphenolic compounds, such as flavonoids, alkaloids, terpenoids, and coumarins, identified by UHPLC-HRMS/MS. The synthesis of SeNPs was conducted in a microwave reactor, at 120 °C and 150 °C, for 30...

Articles
Oliveira TPDS, Lima AKO, Gonçalves TP, Sousa MH, de Aquino Ribeiro JA, Rodrigues CM, Florêncio I, Báo SN, Tada DB, Braga HC, da Silva EC, Muehlmann LA•
PubMed

Botox Injection Combined With Partial Arytenoidectomy: A Novel Approach for Treatment of Episodic Laryngeal Breathing Disorders.

ABSTRACT Objective The aim of this study was to develop effective treatments for episodic laryngeal breathing disorders (ELBD), a series of diverse obstructive respiratory disorders with an unknown pathogenesis. The diseases include paradoxical vocal fold motion/movement disorder (PVFMD), vocal cord dysfunction (VCD), irritable larynx syndrome (ILS), exercise‐induced laryngeal obstruction, and laryngospasm. Methods Five patients with ELBD were involved in this study (60–81 years, average of...

Articles
Zhou Z, Wu JH, Yan PK, Li XX, Kang J, Ge PJ•
PubMed

An endpoint multiplex PCR/RT-PCR for detection of viral agents of bovine respiratory disease.

Bovine respiratory disease (BRD) is a clinicopathological syndrome caused by complex interactions among host and environmental factors, viruses and bacteria. The multi-agent BRD etiology makes laboratory diagnosis challenging, as various pathogens should be investigated for an accurate results. Herein, we describe an endpoint multiplex PCR/RT-PCR for detection of major BRD-associated viruses: bovine herpesvirus 1 (BoAHV-1), bovine pestiviruses (BVDV-1, BVDV-2, HoBiPeV), bovine parainfluenza viru...

Articles
Alessio NHP, Silva Júnior JVJ, Dionisio IF, Dos Santos VS, Gomes V, Weiblen R, Flores EF•
PubMed

Effects of Partial Fishmeal Replacement With Methanotrophic Bacterial Protein (Methylococcus capsulatus) in Siberian Sturgeon (Acipenser baerii) on Growth Performance, Nutrient Utilization, Body Composition, Immune Responses, Liver Histology, Gene Expression, and Gut Microbiota.

This study evaluated the effects of dietary methanotrophic bacterial protein from Methylococcus capsulatus (MCP) as a partial replacement for fishmeal in juvenile Siberian sturgeon (Acipenser baerii). Four isonitrogenous, isolipidic, and isoenergetic diets were formulated containing 0%, 5.25%, 10.50%, or 15.75% MCP, corresponding to 0%, 25%, 50%, and 75% replacement of fishmeal, respectively. A total of 540 fish (23.15 ± 0.35 g) were randomly assigned to experimental diets in triplicate groups o...

Articles
Van Doan H, Hyrsl P, Zuskova E, Angel R, Tomcala A, Nguyen TT, Zare M, Rashidian G, Stejskal V, Tran HQ•
PubMed

Prioritizing Osteoporosis-Associated Candidates Through Multi-Omics Mendelian Randomization, Transcriptomic Modeling, and in vitro Validation.

Background Gut microbiota, immune traits, and circulating metabolites may contribute to skeletal biology. We integrated genetic association analyses, transcriptomic profiling, and cell experiments to prioritize osteoporosis-associated molecular candidates. Methods Two-sample Mendelian randomization (MR), gene prioritization, and three GEO datasets comprising 110 samples were integrated. MR estimates were recalculated while retaining outcome-associated instruments, followed by false-discovery-...

Articles
Sun L, Ni S, Yang K, Zhu X, Tang J, Shi H, Sun X, Ding H•
PubMed

Corrigendum to Markers of compromised gut epithelial barrier integrity increase during the menopause transition.

Original citation: J Clin Invest. 2026;136(17):e205059. https://doi.org/10.1172/JCI205059. Citation for this corrigendum: J Clin Invest. 2026;136(21):e213400. https://doi.org/10.1172/JCI213400. The results section has been updated to correct the upper limit of the confidence interval for the annual reported increase for FABP2. The correct text appears below. During its period of MT-related increase (FMP –2.5 to FMP +6 years), FABP2 rose by 2.6% per year (95% CI 1.7 to 3.4%; P < 0.0001). The...

Articles
Shieh A, Epeldegui M, Karlamangla AS, Jones R, Pacifici R, Greendale GA•
PubMed

Integrating palliative care into respiratory care for people with advanced COPD: study protocol for the international EU PAL-COPD stepped wedge cluster randomised controlled trial of the ICLEAR-EU intervention.

Introduction Individuals with advanced chronic obstructive pulmonary disease (COPD) often experience significant symptom burden, unmet care needs and frequent hospitalisations, yet remain underserved by palliative care. Evidence suggests palliative care can improve quality of life and reduce avoidable hospital readmissions but robust multi-country randomised evaluations are lacking. Building on a successful pilot subsequently adapted, this protocol presents the EU PAL-COPD study evaluating the...

Articles
Van Der Meer MMH, Stevens J, Daenen F, Preston N, Marsden P, Wichmann A, Beernaert K, Dombrecht L, Csikós Á, Grønvold M, Hammer NM, May P, Queiroz Almeida D, Martins Pereira S, Hernández-Marrero P, Verschuur E, Sallnow L, Deliens L, Pardon K, EU PAL-COPD consortium, consortium EU PAL-COPD•
PubMed

Cardiopulmonary Event Prevalence Before First Recorded COPD Diagnosis: A Retrospective Cohort Study Using the Clinical Practice Research Datalink.

Purpose Post-COPD diagnosis, individuals have an increased risk of cardiopulmonary events, but little is known about the risk pre-diagnosis. This study extends previous evidence by investigating the prevalence of cardiopulmonary events before the first recorded COPD diagnosis, including within a standardised 3-year pre-diagnosis window, and compared cardiopulmonary risk with that of matched controls without COPD. Patients and Methods This retrospective, cohort study included patients with a d...

Articles
Russell REK, Pradeep V, Patrick JA, Morgan CL, Chen H, Pollack M, Dods S, Müllerová H, Vogelmeier CF, Singh D, Gale CP, Varghese D•
PubMed

Effect of High-Power Laser Acupuncture on Fatigue and Proprioception in Chronic Nonspecific Low Back Pain: A Randomized Controlled Trial.

Objective To examine the effects of adding high-power laser acupuncture (HPLA) to an exercise program on back muscular fatigability and endurance, lumbar proprioception, pain severity, and pain-related self-efficacy in chronic nonspecific low back pain (CNLBP) patients. Methods Sixty adults with CNLBP aged 20–40 years enrolled in this double-blind, randomized sham-controlled trial with equal and random assignment to receive HPLA plus exercise therapy or sham laser plus the same exercise thera...

Articles
Elimy DA, Elsayed SH, Alshehre YM, Ismail AMA, Alshaikh FJ, Algheryafi RA, Abdrabo MS, Eladl HM, Toson RA, Ali AS, Ali ZA, Khalifa HA, Allam NM•
PubMed

Atrial remodelling defines the heart failure phenotype in hypertrophic cardiomyopathy.

Abstract Background Exercise intolerance is a hallmark of hypertrophic cardiomyopathy (HCM), yet conventional markers including left ventricular hypertrophy, outflow obstruction and systolic function correlate only modestly with functional limitation. Left atrial (LA) remodelling integrates chronic diastolic burden and atrial myopathy and may better characterise the heart failure phenotype of HCM. Objective To determine whether LA remodelling is associated with exercise capacity and clinical...

Articles
Melot A, Al Wazzan A, Saadi MP, Gonzalez De Alaiza Ortega S, Bezard M, Donal E•
POR

Closing the Childhood Lead Testing Gap: The Role of Point-of-Care Testing

by Meridian Bioscience No safe blood lead level in children has been identified, and even low levels are linked to lower IQ, attention problems and poorer school performance. 1 Because the damage cannot be undone, the goal is to identify exposure early and remove the source before lead levels rise. In 2021, the CDC lowered its blood lead reference value (BLRV) from 5.0 to 3.5 &micro;g/dL. The BLRV is not a &ldquo;safe&rdquo; threshold or a measure of toxicity. Rather, it is a population-based...

Point of Care Testing
Meridian Bioscience•