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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 481–492 of 2,098 articles

PLOS

Association of airway CCL28 with type 2 inflammation and secretory IgA in patients with asthma

Objective: This study aimed to investigate sputum CCL28 expression in patients with acute asthma exacerbations and its association with type 2 airway inflammation and secretory IgA. We further evaluated whether sputum CCL28, alone or in combination with routine clinical indicators, could assist in identifying eosinophilic asthma. Methods: This study included 75 patients with non-severe acute asthma and 27 healthy controls. Induced sputum samples were collected, and the levels of CCL28, IL-4, IL-...

Articles
Xiaohan Jiang, Jinmei Zhang, Ke Xu, Xiaobing Yang, Yuanfei Yan, Hao Chai, Jiyong Ma, Ying Shi•
PLOS

Alzheimer’s disease research must connect vascular molecular phenotypes with physiology

Molecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. Longitudinal studies are needed to link molecular and structural changes to vascular mechanics, hemodynamics, and tissue perfusion. Molecular profiling studies have mapped vascular alterations in Alzheimer’s disease, but have not proven a role for them in pathology. This Perspective argues for longitudinal studies to link molecular and structural changes to vasc...

Articles
Thomas S. Lewis, Jessica Wagner, Jonas J. Neher•
PubMed

Bilateral Iatrogenic Pneumothorax After Acupuncture in a 26-Year-Old Woman Presenting With Cough, Pleuritic Chest Pain, and Tachycardia: A Case Report.

Patient: Female, 26-year-old Final Diagnosis: Bilateral iatrogenic pneumothorax Symptoms: Persistent cough • pleuritic chest pain • difficulty taking a full breath Clinical Procedure: — Specialty: Pulmonology Objective: Unusual clinical course Background Acupuncture is widely used and generally safe, but pneumothorax is a serious complication of needling in the neck, shoulder, or upper back. Bilateral pneumothorax is rare and can present with nonspecific symptoms, delaying diagnosis. This...

Articles
Nożewski J, Zalewska B, Zwierko B•
PubMed

IL-27 Reduces Cell-Surface LDLR in Human Macrophages and Restricts VSV-G-Pseudotyped HIV infection.

The low-density lipoprotein receptor (LDLR) is a major cellular receptor for vesicular stomatitis virus glycoprotein (VSV-G), which is widely used to pseudotyped virus vectors. A replication incompetent VSV-G-pseudotyped HIV (VSV-G-HIVLuc) has been used in HIV infection studies. Although IL-27-polarized macrophages induce multiple antiviral genes and resist replication-competent HIV infection, their impact on VSV-G-HIVLuc infection has not been studied. Here, we evaluated the role of IL-27 polar...

Articles
Chen Q, Kariyawasam U, Maruquez M, Metz J, Yang J, Rupert A, Imamichi T•
PubMed

Economic evaluation of the global congenital syphilis prevention benefit of a prospective syphilis vaccine.

Abstract Introduction Globally, congenital syphilis (CS) disease burdens remain high and their eradication remains elusive. Syphilis vaccines (SV) in preclinical development can contribute to CS prevention. Evaluating this contribution helps rationalise development efforts, supports payer planning and predicts demand. Methods We economically evaluate, from a societal perspective, the CS-related impacts of a hypothetical single-dose SV administered to representative 15-year-old females in 189...

Articles
Sevilla JP, Burnes D, Bloom DE•
PubMed

Endoscopic hemostasis using a narrow-caliber endoscope for a bleeding duodenal ulcer in a 7-month-old infant: A case report.

Abstract Duodenal ulcers are rare in infants, and their endoscopic management is challenging because of anatomical factors and limited availability of hemostatic devices compatible with narrow‐caliber endoscopes. Here, we present the case of a 7‐month‐old female infant who developed upper gastrointestinal bleeding 9 days post‐cardiac surgery while receiving aspirin therapy. Emergency esophagogastroduodenoscopy revealed a bleeding duodenal ulcer with an exposed vessel. Because of the inability t...

Articles
Hayashi S, Yamazaki K, Tanaka H, Yamashita K, Ozawa N, Shimizu S, Shimizu M•
PubMed

Mapping the Care Journey of Children with Nephrotic Syndrome from Caregivers' Perspectives: A Qualitative Study.

Background Childhood nephrotic syndrome often follows a relapsing course requiring prolonged treatment, monitoring, and substantial family involvement. This study aimed to map the caregiver-informed care journey of children with nephrotic syndrome and examine how caregiving challenges and support needs changed across four phases: diagnosis and assessment, inpatient treatment, transition to home, and long-term management. Methods A descriptive qualitative design incorporating caregiver-informe...

Articles
Liang J, Lv Y, Wang X, Zhong H•
PubMed

Severe Hypertriglyceridemia Associated With Acute Pancreatitis in a Patient on Risankizumab.

ABSTRACT Hypertriglyceridemia is a frequent condition, and it has many causes including obesity, hypothyroidism, and some medication. Exploring the cause is mandatory to avoid complications such as acute pancreatitis. We reported a case of hypertriglyceridemia-induced pancreatitis, started after starting risankizumab for Crohn's disease. This case describes the possible association between the increase of triglyceride level and the use of risankizumab, which was revealed by hypertriglyceridemia...

Articles
El Yazal S, Chokshi A, Hudhud D•
PubMed

Predicting PANSS symptoms in schizophrenia spectrum disorders using speech only: an international, multi-centre, computational secondary analysis across multiple languages.

Summary Background Speech carries cues to variation in mental state in schizophrenia, typically indexed with clinician-rated scales such as Positive and Negative Syndrome Scale (PANSS). In this study, we aggregate multi-centre recordings to assemble a large corpus and assess symptom-prediction models at scale, to enable rater-independent, efficient, and reproducible assessments for early detection of relapse-related signals from speech. Methods In this computational secondary analysis, we co...

Articles
He R, Kirdun M, Palominos C, Orejudo LN, Barthelemy S, Bhola S, Ciampelli S, Decker A, Demirlek C, Fusaroli R, García-Molina JT, Gimenez G, Hüppi R, Koelkebeck K, Lecomte A, Qiu R, Simonsen A, Tourneur V, Verim B, Wang H, Yalincetin B, Yin S, Zhou Y, Amblard M, Arriola RA, Bora E, de Boer J, Figueroa-Barra AI, Koops S, Musiol M, Palaniyappan L, Parola A, Spaniel F, Tang SX, Sommer IE, Homan P, Hinzen W•
PubMed

Implementing Routine Mental Health Screening and Structured Follow-up for Youth With Juvenile Idiopathic Arthritis: A Single-center Quality Improvement Project.

Introduction: Youth with juvenile idiopathic arthritis (JIA) have higher rates of anxiety and depression, yet pediatric rheumatology clinics rarely embed systematic mental health care into routine care. Unrecognized symptoms can impair physical functioning and disease management. The objectives of this quality improvement initiative were to increase (1) anxiety/depression screening from 0% to ≥75% and (2) algorithm-concordant follow-up for youth screening positive from 0% to ≥75%. Methods: Ou...

Articles
Xiao E, Beattie K, Cellucci T, Dushnicky M, Heale L, Herrington J, Prowse K, Batthish M•
PubMed

Allergic rhinitis as a potentially modifiable contributor to small airway dysfunction and incomplete clinical remission in severe asthma.

To the Editors, We read with great interest the article by Al-Ahmad et al, which demonstrated that small airway dysfunction (SAD) is a functional barrier to spirometry-defined clinical remission (CR) in severe asthma treated with biologic therapies.1 We congratulate the authors on this important work, which highlights the complementary value of impulse oscillometry (IOS) and spirometry in assessing distal airway impairment. However, we would like to draw attention to one finding that deserves...

Articles
Wu H, Ouyang Q•
PubMed

Associations of Mediterranean Diet Adherence, Dietary Glycemic Index, and Antioxidant Intake With Acne Vulgaris: A Case–Control Study in Young Adults.

ABSTRACT Background Dietary patterns, glycemic characteristics, and oxidative balance have been implicated in acne vulgaris, although findings remain inconsistent. Aim This study evaluated the associations of Mediterranean diet adherence, dietary glycemic index (GI), and dietary antioxidant score with acne vulgaris in young adults. Methods This case–control study included 279 participants (115 acne/164 controls). Dietary intake was assessed using three‐day food records, and Mediterranean d...

Articles
Özturan‐Şirin A, Yazıcı A•