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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 493–504 of 2,098 articles

PubMed

Keratinocyte TMEM79 protects early life epidermal homeostasis and restrains STING-dependent skin inflammation.

Abstract Chronic inflammatory skin diseases are characterized by epithelial barrier dysfunction and immune dysregulation, yet the epithelial-intrinsic mechanisms that initiate inflammation remain poorly understood. TMEM79 is a dermatitis-associated transmembrane protein expressed in keratinocytes, but how its loss promotes skin disease remains unclear. Here, using keratinocyte-specific Tmem79 conditional knockout (cKO) mice and TMEM79-deficient human keratinocytes, we find that TMEM79 is requir...

Articles
Ge M, Predes D, Kwong AC, To E, Chen M, Jain A, Wei W, Ordovas-Montanes J, Leyva-Castillo JM, Chiu IM, He X•
PubMed

Development of novel Mu opioid receptor antagonists based on a 6,4-spiro bicyclic fentanyl-derived scaffold.

Scaffold reorganization represents a strategy for modulating Mu opioid receptor (MOR) signaling within flexible opioid scaffolds. Herein, a 6,4-spiro bicyclic core derived from the fentanyl framework was adopted to reduce conformational flexibility while preserving key pharmacophoric features of the parent 8-membered scaffold. Biological evaluations identified compound 3, bearing 2-furanyl and cyclobutylmethyl substituents, as the most potent analogue in this series. Compound 3 exhibited MOR bin...

Articles
Li E, Neel LT, Upadhyay N, Reda A, Kale BS, Long Z, Opare A, Woodard S, Selley DE, Dewey WL, Pagare PP, Zhang Y•
PubMed

Moderna/Merck-first out of the gate with a personal neoantigen cancer vaccine-who else is in the race and what strategy(ies) will win?

Moderna/Merck are expected to present their data at this 2026 European Society for Medical Oncology (ESMO) Congress demonstrating that the combination of a personal neoantigen cancer vaccine, prepared as a messenger RNA (mRNA) in lipid nanoparticle (LNP) format, and standard-of-care anti-programmed cell death protein 1 (PD-1) antibody (pembrolizumab) is more effective than anti-PD-1 alone in the adjuvant setting of stage IIB-IV melanoma. This is a big win for the up-again, down-again field of ca...

Articles
Fritsch EF, Wu CJ•
PubMed

Real-world effectiveness of Paxlovid in protecting Long COVID for outpatient adult patients: A target trial emulation study from the RECOVER Initiative.

Paxlovid (nirmatrelvir/ritonavir) has been approved for use in patients who are at high risk for severe acute COVID-19 illness. Evidence regarding whether acute use of Paxlovid protects against Post-Acute Sequelae of SARS-CoV-2 infection (PASC), or Long COVID, is mixed in high-risk patients and lacking in low-risk patients. With a target trial emulation framework, we evaluated the association of Paxlovid treatment within 5 days of SARS-CoV-2 infection with incident Long COVID and hospitalization...

Articles
Zang C, Li H, Khullar D, Zhang Y, Strobel S, Chen Y, Sala MA, Patel PB, Comellas AP, Wylam A, Weiner M, Forrest CB, Carton T, Wang F, Kaushal R, RECOVER Consortium•
PubMed

Red Light Therapy and Mitochondrial Rejuvenation in Age-Related Disorders.

Aging is associated with mitochondrial dysfunction, impaired ATP production, and a decline in tissue regenerative capacity, leading to the development of age-related diseases. This review summarizes current evidence regarding the effects of photobiomodulation (PBM) on mitochondrial function and age-related disorders. PBM using red and near-infrared light may enhance proper mitochondrial function by acting on cytochrome c oxidase (CCO) and other signaling pathways, including the transient recepto...

Articles
Iglewska M, Flis KA, Kołakowska M, Hryniewicz WW, Pluto-Prądzyńska A•
PubMed

Cancer-Associated Fibroblasts-Orchestrated Immune Remodeling as a Key Driver in Liver Cancer.

Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA) develop within a highly immunosuppressive tumor microenvironment (TME) characterized by chronic inflammation, extensive stromal remodeling, and impaired antitumor immunity. Among stromal components, cancer-associated fibroblasts (CAFs) have emerged as key regulators of tumor progression and immune homeostasis. This review provides an overview of CAF-mediated immune remodeling in primary liver cancers, with particular empha...

Articles
Porro N, Marri S, Salani F, Marra F, Gragnani L, Gentilini A•
PubMed

Chaihuang weikuining protects against ethanol-induced gastric ulcer through modulation of gut microbiota and inhibition of JAK1/STAT3 signaling.

Background Chaihuang weikuining (CHWKN) is a traditional Chinese medicinal formula with reported anti-ulcer activity. However, the underlying mechanisms remain unclear. This study aimed to investigate the protective effects of CHWKN against ethanol-induced gastric ulcer (GU) and to explore the role of gut microbiota in mediating these effects. Methods An ethanol-induced GU model was established in rats. Histological staining (H&E and PAS) and biochemical analyses were used to evaluate gastric...

Articles
Fu A, Guo R, Wang K, Zhuge H, Ying G, Ma W, Ding Q, Li S, Bao J, Yu W•
PubMed

Case Report: Successful peripartum management of acquired hemophilia A relapse during pregnancy.

Background Few reports of Pregnancy-related Acquired hemophilia A (AHA) manifested prenatally. Due to rarity, there are no definitive guidelines for the peripartum management of pregnant women with AHA and their newborns. Case presentation we report a 30-year-old woman with relapsed AHA during pregnancy. She maintained partial remission with cyclosporin, underwent cesarean section with rFVIIa prophylaxis, and controlled postpartum bleeding. The newborn had transient FVIII inhibitors without b...

Articles
Chen H, Yu X, Zhu T•
PubMed

Beyond PET/CT: the evolving role of circulating tumor DNA in follicular lymphoma.

Introduction Response assessment in follicular lymphoma (FL) has traditionally relied on imaging. The introduction of 18F-FDG PET/CT represented a major advance over anatomical assessment and established end-of-treatment metabolic response as a powerful prognostic marker in FL (1, 2). Nevertheless, PET remains an indirect measure of lymphoma biology. FDG uptake may reflect inflammation, immune activation, or treatment-related changes, whereas low-volume residual disease may remain below the spa...

Articles
Barrio S, Martín-Muñoz A, Jiménez-Ubieto A•
PubMed

The effects of physical exercise on executive function, internalizing symptoms and externalizing symptoms in children and adolescents with attention-deficit/hyperactivity disorder: a systematic review and meta-analysis.

Background The aim of this study is to comprehensively assess the potential effects of physical exercise on executive function, internalizing symptoms and externalizing symptoms in children and adolescents with attention-deficit/hyperactivity disorder (ADHD), and to explore the moderating factors influencing these effects. Methods We performed a systematic search of six databases (including Web of Science, PubMed, Embase, PsycNET, the Cochrane Library and SPORTDiscus). Data analysis was perfo...

Articles
Shi J, Zheng X, Wang W•
PubMed

The association of body weight status with hypertriglyceridemia among community-dwelling older adults in regional China.

Aim To investigate associations of body weight with hypertriglyceridemia (HTG) among older adults in regional China. Methods In this cross-sectional study, non-diabetic community-dwelling adults aged 60 + years and not receiving anti-lipid medications were randomly determined from Nanjing municipality, China, in 2023. HTG was defined based on fasting triglyceride concentration. Body weight status was assessed with waist circumstance (WC) and body mass index (BMI), respectively. Mixed-effects...

Articles
Lu S, Lu Y, Ao G, Yang L, Ji Y, Xu T, Tang W, Xu F•
PubMed

Reduced photoreceptor layer thickness in early type 2 diabetes mellitus is associated with decreased contrast sensitivity: a prospective cross-sectional study.

Purpose To investigate changes in contrast sensitivity (CS) in patients with Type 2 Diabetes Mellitus (T2DM) with no diabetic retinopathy (DR) or nonproliferative diabetic retinopathy (NPDR) and to assess the relationships between these alterations and early retinal microstructure. Methods This prospective cross-sectional study included subjects aged 40–60 years, including 30 healthy controls, 30 individuals with T2DM without DR, and 30 individuals with T2DM and NPDR. General data from all gr...

Articles
Tu Y, Zhu X, Sun Y, Sun X, Cao G•