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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 517–528 of 2,098 articles

PubMed

Efficacy and safety of sivelestat in sepsis-induced acute respiratory distress syndrome: an updated meta-analysis based on disease severity and treatment strategy subgroups.

Objective Sivelestat sodium hydrate is a selective neutrophil elastase inhibitor that attenuates neutrophil-mediated alveolar–capillary injury and is used in some East Asian countries for acute lung injury/ARDS. We evaluated the efficacy and safety of sivelestat in sepsis-induced acute respiratory distress syndrome (ARDS) and explored whether disease severity, baseline mortality risk, and treatment background modify the mortality effect. Methods We searched PubMed/MEDLINE, Embase, Cochrane CE...

Articles
Haibier A, Ma J, Wang Y, Wu T•
PubMed

Control and prevention strategies of porcine respiratory disease complex: current evidence and future directions.

Porcine Respiratory Disease Complex (PRDC) is a multifactorial disease with a major economic impact on the global swine industry. Its emergence and progression are strongly influenced by interactions among infectious agents, environmental conditions, and management practices, making its prevention and control particularly challenging. This review summarizes the principal strategies and emerging approaches for PRDC prevention and control, highlights recent advances, and discusses their potential...

Articles
Pastor-Calonge AI, Mencía-Ares Ó, Manzanares-Vigo L, Cid-González A, Gutiérrez-Martín CB, Martínez-Martínez S•
PubMed

Low-intensity extracorporeal shock wave therapy for pediatric respiratory diseases: current evidence and translational barriers.

Low-intensity extracorporeal shock wave therapy (Li-ESWT) has demonstrable mechanobiologic activity in nonpulmonary systems, where it has been linked to adenosine triphosphate (ATP) release and downstream signaling, macrophage and fibroblast responses, matrix remodeling, and tissue repair. Whether those effects extend to pediatric respiratory disease is uncertain. Adult clinical studies indicate biologic responsiveness in selected inflammatory or reparative settings, but effect sizes are variabl...

Articles
Su X, Liu D, Liu J, Lv D, Guo J, Hui Q, Ye F, Chen Y, Wang C, Tang L, Xia M, Zhang Q•
PubMed

A single-cell atlas of the human respiratory system identifies a monocyte-centered HSPA1B(+) inflammatory primed state associated with WTAP.

Chronic obstructive pulmonary disease (COPD) is characterized by persistent pulmonary inflammation and tissue remodeling, yet the cellular states and regulatory mechanisms underlying monocyte functional heterogeneity remain incompletely understood. Here, we generate a high-resolution single-cell transcriptomic atlas of the human respiratory system and identify a diverse monocyte functional landscape in healthy lungs containing a HSPA1B+ inflammatory monocytes state. This population exhibits enha...

Articles
Wang Y, Zhu L, Zhu Y, Chen G•
PubMed

Distinct calcium responses distinguish itch- and pain-associated neurons in the anterior cingulate cortex.

Itch and pain are distinct aversive sensations. We previously identified segregated neuronal populations in the anterior cingulate cortex (ACC) that selectively respond to pain and itch stimuli and reported full-trace classification with a mean-frequency difference, leaving the broader calcium-transient properties associated with this separation unresolved. Here, we reanalyzed denoised in vivo calcium traces from stimulus-responsive ACC neurons and quantified interpretable response features, inc...

Articles
Lee C, Ko HG•
PubMed

Can routine chest CT with artificial intelligence tool be used for opportunistically osteoporosis screening? A preliminary study.

Introduction Patients with pulmonary diseases face an elevated risk of osteoporosis. Conventional diagnosis relies on quantitative computed tomography (QCT), which delivers a high radiation dose and requires a dedicated scan. Whether conventional chest CT can be used for osteoporosis screening remains uncertain. Methods A deep learning system was used to measure bone mineral density (BMD) in routine chest CT scans for osteoporosis screening, with QCT as the reference standard. A total of 98 p...

Articles
Zhang R, Li H, Lu M, Chen S, Huang C•
PubMed

Magnolol alleviates high-fat diet-induced steatosis, inflammation and fibrosis in obesity-associated liver injuries via MOGAT1-mediated lipid metabolism and NF-κB signaling.

Background Magnolol (MAG), a bioactive compound from Magnolia officinalis, possesses anti-inflammatory and lipid-lowering properties, but its role in obesity-associated liver injury and its molecular targets remain unknown. Methods High-fat diet (HFD)-fed mice were treated with MAG (10 or 20 mg/kg) daily for 7 days. AML12 hepatocytes were challenged with PA with or without MAG pretreatment. Liver injury was evaluated by histology, serum biochemistry, qPCR and Western blot. RNA-seq and mechani...

Articles
Huang Z, Huang Z, Luo L, Wu Z, Wen Z, Xiao Z•
PubMed

Triterpenoids – future multi-target compounds against obesity and towards restoration of metabolic health.

Obesity and its associated diseases represent one of the most urgent public health crises of our time, affecting billions worldwide. Current pharmacological agents, such as GLP-1 and GLP-1/GIP receptor agonists, have demonstrated high clinical efficacy in diabetes and weight management. However, the required lifelong medication is often limited by high economic costs and severe side effects, including gastrointestinal complications. Consequently, the search for complementary therapies is invalua...

Articles
Becker J, Ebert BE, Festel G, Blank LM•
PubMed

Contemporary diagnosis and management of vestibular migraine: a systematic review of conventional and CGRP-targeted therapies.

Background Vestibular migraine (VM) is a common cause of recurrent episodic vertigo, and it is associated with significant disability from recurrent vestibular and migraine symptoms. While there are a number of standard preventive treatments, their effectiveness is quite variable, and new treatments which target calcitonin gene-related peptide (CGRP) have been identified as potential treatments. The purpose of this systematic review was to assess the state of the art in the diagnosis of vestibu...

Articles
Alabood S, Aldokhail L, Alotaibi E, Alsaqr M, Alshehri A, Bakry E•
PubMed

Stem cells, extracellular vesicles, and cell-free strategies in pulmonary arterial hypertension: a bibliometric study, 2006–2026.

Pulmonary arterial hypertension (PAH) remains a high-mortality vasculopathy for which no current therapy reverses established vascular remodeling. Stem cell-based and cell-free extracellular vesicle (EV) therapies are promising disease-modifying strategies, yet prior PAH bibliometric studies have not treated this stem-cell-to-cell-free arc as a dedicated, continuous research front. We analyzed 891 articles and reviews (1 January 2006 to 15 March 2026) from the Web of Science Core Collection and...

Articles
Xue X, Zhang H, Cao Y, Wang Z, Song Q, Han J, Wang D, Wu Y, Liu Q•
PubMed

The association between obesity index and hypertension in type 2 diabetes: a cross-sectional study.

Background The present study explored the association between the Chinese visceral adiposity index (CVAI) and lipid accumulation product (LAP) and hypertension in type 2 diabetes mellitus (T2DM) subjects. Methods A total of 4,155 T2DM individuals were enrolled from the Second Hospital of Shijiazhuang in this cross-sectional investigation. We employed multivariable logistic regression, restricted cubic spline (RCS) modeling, threshold effect assessment, and stratified subgroup analyses. Missin...

Articles
Xing Y, Yin Y, Zhao Q, Zhang L, Xiu X•
PubMed

A study on the correlation between serum anti-Müllerian hormone levels in male participants of pre-pregnancy genetic health checkup in Qingyang District, Chengdu City.

Objective To explore the relationship between serum anti-Müllerian hormone (AMH) levels and semen quality in men undergoing preconception health checkups. Methods A total of 145 male preconception patients were enrolled. Semen parameters, including sperm kinetics, were measured via computer-aided sperm analysis (CASA), and serum AMH levels were detected using chemiluminescence immunoassay. Spearman’s correlation and multivariate linear regression analyses were used for statistical analysis....

Articles
Kou H, Gui C, Liu F, Sheng X•