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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 529–540 of 2,098 articles

PubMed

Pharmacomicrobiomics of GLP-1 receptor agonist gastrointestinal tolerability: integrating host genetics and the gut microbiome.

Gastrointestinal (GI) adverse events, such as nausea, vomiting, diarrhea, and constipation, remain a dominant barrier to the sustained use of GLP-1 receptor agonists (GLP-1 RAs), driving discontinuation independently of the drug’s metabolic benefits. Two host-side biological systems have been independently established as determinants of this variability. The first is host genetics, anchored by a 2026 genome-wide association study in which GLP1R variants predicted both weight-loss efficacy and na...

Articles
Kumbhare SV, Pedroso I, Sinha R, Almonacid DE•
PubMed

Effects of different electrical stimulation on depression: a systematic review and network meta-analysis.

Background Depression is a prevalent psychiatric disorder characterised by persistent low mood and anhedonia, substantially impairing quality of life. Conventional treatments show variable efficacy and tolerability, with high post-discontinuation relapse rates. Electrical stimulation has emerged as an alternative intervention, but comparative efficacy and safety of different modalities remain uncertain. This systematic review and network meta-analysis aimed to synthesise evidence and quantitati...

Articles
Chai J, Li S, Huang J, Yao S, Zhou L, Chen X, Liu F, Ji C, Chen H, Tan S, Li R, Ma R, Li S, Zhao S•
PubMed

Case Report: Severe depression and suicidality in a young patient with RYR1-related congenital myopathy.

Background RYR1-related congenital myopathies (RYR1-CMYO) are rare inherited neuromuscular disorders characterized by considerable clinical and histopathological heterogeneity. Although chronic physical disability may be associated with substantial psychological burden, psychiatric manifestations in patients diagnosed with RYR1-related disorders remain insufficiently characterized. Case presentation We report the case of an 18-year-old man with a longstanding RYR1-related congenital myopathy...

Articles
Radu ŞA, Vasiliu O, Tudor C•
PubMed

Pulmonary function report capture and rule-based text indexing in an inpatient EHR cohort with recorded COPD.

Background Inpatient electronic health record (EHR) extracts may not contain pulmonary function reports stored in outpatient or laboratory systems. Before report text is used to refine a chronic obstructive pulmonary disease (COPD) research cohort, investigators need to know how much of that text is captured and whether this capture is selective. Herein, we audited pulmonary function report capture and built a transparent index of literal report terms. Methods We conducted a single-center ret...

Articles
Yang K, Li C, Chen W, He J, Yalikun M, Dong J•
PubMed

Eight-week flexi-bar vibration exercise improves cardiovascular function accompanied by altered gut microbiota and metabolites in middle-aged and elderly women: a randomized controlled trial.

Aims This study aimed to investigate the impact of 8-week FE on cardiovascular health in middle-aged and elderly women and explore correlational associations involving gut microbiota and its metabolites. Methods Thirty middle-aged and elderly women were randomly divided into FE group and control group. Body composition parameters were assessed using a body composition analyzer. cfPWV and baPWV were detected to assess central and systemic arterial stiffness, respectively. To evaluate central h...

Articles
Gao D, Deng W, Hu M, Mai Y, Liang G, Wu J, Wu Y, Guo J, Huang J•
PubMed

Digital twin technology in cardiovascular care: future perspectives for nursing practice, patient management, and clinical decision-making.

Background and objective Cardiovascular diseases remain the leading cause of mortality globally and continue to impose substantial clinical, economic, and organisational burdens on healthcare systems due to increasing disease complexity, recurrent hospitalisations, and the need for long-term monitoring and personalised care. Rapid advances in artificial intelligence, computational modelling, wearable biosensors, telehealth, and digital health technologies have accelerated the emergence of Digit...

Articles
Shafqat N, Verma V, Naseema S•
PubMed

Paired metabolomics identify associations between fecal and serum metabolites in cardiovascular-kidney-metabolic syndrome.

Background Whether fecal metabolic alterations are associated with circulating metabolic changes in cardiovascular-kidney-metabolic (CKM) syndrome remains unclear. We compared serum and fecal metabolites between different CKM stages and investigated fecal-serum associations. Methods Forty-four participants participated in the cross-sectional study, including 19 subjects in CKM stages 1–2 and 25 subjects in CKM stages 3-4. All participants underwent untargeted serum and fecal metabolomics and...

Articles
Zhao Z, Dai J, Zou Y, An X, Zhang Y, Zhu C, Hao L, Jia L•
PubMed

Retraction: Corrigendum: Anticancer effects of ABTL0812, a clinical stage drug inducer of autophagy-mediated cancer cell death, in glioblastoma models.

The journal retracts the 22 January 2025 article cited above. Following publication, concerns were raised regarding the integrity of the images in the published figures. The authors failed to provide a satisfactory explanation during the investigation, which was conducted in accordance with Frontiers' policies. This retraction was approved by the Chief Editors of Frontiers in Pharmacology and the Chief Executive Editor of Frontiers. The authors received a communication regarding the retraction...

Articles
Frontiers Editorial Office•
PubMed

Development and validity and reliability testing of a questionnaire on life and death education cognition and selection preference of cancer patients.

Objective To develop a questionnaire on life and death education cognition and selection preference of cancer patients and test its reliability and validity. Methods This study is a methodological research aimed at developing a questionnaire and conducting psychometric evaluation on it. The 5W1H method is used as the theoretical framework for the preference dimensions of life and death education. The initial questionnaire was developed through literature analysis, qualitative interviews, and...

Articles
Huang R, Zhang X, Chen W, Li Y, Li J•
PubMed

Implementation of rural telehealth physical therapy for chronic low back pain: qualitative findings informing a randomized clinical trial aimed at decreasing opioid use.

Background Low back pain (LBP), the most expensive health condition in the United States, accounts for over $134.5 billion in federal spending. As a leading cause of disability worldwide, LBP is a common reason for initiating prescription opioid therapy and often requires ongoing multidisciplinary care. In rural settings, where provider shortages, transportation barriers, and geographic constraints limit access to preventive and specialty healthcare for approximately 60 million Americans, teleh...

Articles
Ali KJ, McLaughlin KH, Boyér LL, Martino G, Skolasky RL•
PubMed

Association between multimodal pelvic floor rehabilitation and symptom improvement in postpartum women with low back pain and constipation: a retrospective cohort study.

Objective To examine the association between multimodal pelvic floor rehabilitation and improvements in low back pain, functional disability, and constipation-related symptoms among postpartum women with concomitant low back pain and constipation. Methods This single-center retrospective observational cohort study screened 410 postpartum women who underwent rehabilitation assessment between January 2023 and December 2025. Of these, 352 met the baseline eligibility criteria and initiated rehab...

Articles
Feng Y, Xiao G, Zhu Y, Li Y, Xu X•
PubMed

Association between an improved positioning management strategy and non-incisional low back pain and sleep quality in patients undergoing modified radical mastectomy for breast cancer: a retrospective cohort study.

Background Non-incisional low back pain, particularly low back pain, and sleep disturbance are common yet underrecognized problems during early recovery after breast cancer surgery. This study evaluated whether an improved positioning management strategy was associated with reduced non-incisional low back pain and improved postoperative sleep quality. Methods This single-center retrospective cohort study included adult women who underwent modified radical mastectomy or simple mastectomy for b...

Articles
Sun H, Zhang M, Feng S, Zhang W, Liu Z, Liang C, Liu Y, Sun X•