Clinical intelligence & editorial.

PubMed

Tumor necrosis factor inhibitors and cardiovascular outcomes in adults with moderate-to-severe plaque psoriasis: a systematic review and meta-analysis.

Background Moderate-to-severe plaque psoriasis is associated with persistent systemic inflammation and increased cardiovascular risk. Objectives To evaluate the association between anti-TNF therapy and clinical cardiovascular outcomes in adults with moderate-to-severe plaque psoriasis. Methods The authors conducted a systematic review and meta-analysis in accordance with PRISMA 2020 and prospectively registered the protocol in PROSPERO (CRD420251270784). Randomized controlled trials and com...

Plaque Psoriasis

Mesa Rodríguez LF, Zambrano Aristizábal A, Vega Padilla JD• October 27, 2026

PubMed

Distrust as a global disease with special reference to cardiology.

Twenty years ago, writing from India, one of us described distrust as a ‘third burden’ confronting medicine. Alongside infectious and cardiovascular disease, a quieter disorder was spreading: erosion of trust among physicians, patients, institutions, and society. The concern was not merely reputational. Trust was part of medicine’s infrastructure; without it, even technically excellent care could fail.1 Two decades later, writing from Italy and within a very different healthcare environment, th...

Cardiology

Tona F, Kothari SS• October 27, 2026

PubMed

American Society of Hematology 2026 guidelines for immune thrombocytopenia: initial and second-line therapy for adults with primary ITP.

Background Since publication of the American Society of Hematology 2019 Guidelines for Immune Thrombocytopenia (ITP), new clinical trials have been completed, and new treatments have become available. Objective These evidence-based guidelines from the American Society of Hematology (ASH) are a focused update of the 2019 ASH ITP guidelines, centering on treatment of adults with primary ITP. Methods ASH formed a multidisciplinary guideline panel that included 2 patient representatives and was...

Hematology

Cuker A, Terrell DR, Sowdagar H, Arnold DM, Audia S, Bussel JB, González-López TJ, Grace RF, Masias C, McCrae KR, Mitrovic M, Neunert C, Panch SR, Shah S, Shy B, VandeVelde J, Cines DB, Vesely SK• October 27, 2026

PubMed

Characterization of the Preclinical in Vitro and in Vivo Pharmacokinetic Properties of the Cyclic Oligomeric Depsipeptide Ryanodine Receptor 2 Inhibitor ent-Verticilide.

ent-Verticilide is a synthetic cyclic oligomeric depsipeptide that inhibits ryanodine receptor 2 (RyR2)-mediated calcium (Ca) leak and has demonstrated antiarrhythmic activity in mice. This study characterized the preclinical absorption, distribution, metabolism, and pharmacokinetic properties of ent-verticilide and investigated factors affecting its oral exposure. ent-Verticilide was stable in rat plasma and simulated gastric and intestinal fluids but exhibited extensive plasma protein binding...

Ent

Do TQ, Crouch RD, Wu K, Thorpe MP, Smith AN, Johnston JN, Akers WS, Knollmann BC• October 27, 2026

PubMed

A Dual-parameter 3D Assessment of Alveolar Cleft Bone Grafts: Integrating Bone Density and Modified Volumetry.

Background: Alveolar cleft is a discontinuity of the maxillary alveolar process commonly associated with cleft lip and palate, leading to functional and aesthetic impairments. Secondary alveolar bone grafting (SABG) is the standard treatment to restore continuity. However, conventional postoperative evaluation relies solely on volume measurement. Although 3D computed tomography is widely used for this purpose, it ignores the porous, trabecular nature of newly formed bone (NFB), resulting in sys...

Bone Density

Deng M, Wei S, Wang Y• October 27, 2026

PubMed

Differences in A1C trajectory by sex and BMI in paediatric type 1 diabetes: a retrospective cohort study using a diabetes registry in British Columbia, Canada.

Abstract Objectives To determine if there are differences in Hemoglobin A1C (A1C) trajectory by sex among children and youth living with type 1 diabetes and to examine how this would be modified by body mass index (BMI). Design Retrospective cohort study using the British Columbia Pediatric Diabetes Registry (BC-PDR), a provincial paediatric diabetes registry that started enrolling patients in 2017 and included data up to 2 years prior to enrolment. Setting Data were extracted from the BC-...

A1c

Leung JM, Braschel M, Bone JN, Amed S• October 27, 2026

PubMed

From single-cell atlases to predictive intercellular response networks in liver cancer.

Cancer research has long been driven by the search for altered genes, deregulated pathways, and molecular subclasses. In liver cancer, this perspective has been highly productive, but it is no longer sufficient. Liver cancer usually develops in chronically diseased tissues shaped by inflammation, fibrosis, cirrhosis, metabolic stress, vascular remodeling, and immune adaptation. Therefore, the decisive biological question is increasingly not only which pathway is altered, but where, in which cell...

Liver Cancer

Weiskirchen R• October 27, 2026

PubMed

Implementing "Community-based approach for lowering stress through mindfulness in Chicago" (CALM-Chicago) for depression and hypertension: Study protocol of a proof-of-concept trial.

Background Community-based mental health interventions hold potential to reach communities who are less likely to engage in traditional clinic-based services. Partnering with community members and organizations to develop a community-informed approach increases the likelihood of successful implementation of these interventions. We will evaluate the effectiveness and implementation of an adapted mindfulness-based stress reduction intervention among Black/African American adults with comorbid dep...

Depression

Carroll AJ, Davis P, Reed LR, Ellis A, Kandula NR, Kho AN, Youmans QR, Maletich CM, Huffman MD, Smith JD, Burnett-Zeigler IE• October 27, 2026

PubMed

Integrating machine learning and traditional statistics to evaluate the Uric acid-to-HDL cholesterol ratio for identification of prevalent COPD in older adults.

Background The uric acid-to-high-density lipoprotein cholesterol ratio (UHR) is a novel inflammatory and metabolic biomarker, but its association with chronic obstructive pulmonary disease (COPD) in older adults remains unclear. This study investigated the relationship between UHR and COPD prevalence among adults aged ≥ 60 years. Methods This cross-sectional study analyzed 5,277 participants aged ≥ 60 years from NHANES 2013–2018. Weighted multivariable logistic regression estimated the UHR–CO...

Cholesterol

Li L, Fu C, Zhang R, Zhang M, Tian X• October 27, 2026

PubMed

A web-based risk communication tool for anticipatory dental anxiety related to MRONJ concerns in older adults receiving antiresorptive therapy: An explanatory sequential mixed methods study.

Objective To evaluate feasibility, acceptability, and immediate patient-reported outcomes of Dental Confidence, a web-based risk communication tool addressing anticipatory dental anxiety in the context of medication-related osteonecrosis of the jaw (MRONJ) in older adults receiving antiresorptive therapy. Methods In this prospective single-arm explanatory sequential mixed methods study, 51 participants completed assessments before and immediately after application use. Five participants were...

Anxiety

Suwanaratana R, Rujiraphan T, Wiphakphongpakorn P, Chanalithichai N• October 27, 2026

PubMed

Blood-Based Biomarkers in Alzheimer's Disease: Advances in Detection Technologies and Clinical Applications.

ABSTRACT Alzheimer's disease (AD) is a neurodegenerative disorder. Irreversible pathological alterations are already present when clinical symptoms emerge. Therefore, early diagnosis and intervention are crucial for improving patient outcomes and reducing the social and healthcare burden. With its advantages of minimal invasiveness, convenience, affordability, and high accessibility, blood‐based testing has overcome the limitations of conventional methods, becoming a major focus of research in...

Alzheimer’S Disease

Li S, Huang L, Guo Q• October 27, 2026

PubMed

Executive Summary of the 2025 World Allergy Organization Guidelines for Hereditary Angioedema.

This Executive Summary is intended to provide a concise overview of the key concepts and recommendations of the 2025 World Allergy Organization Guidelines for Hereditary Angioedema. It should be read and cited in conjunction with the full guideline, which remains the primary source for the complete recommendations, supporting evidence, and methodological framework.1 Introduction Hereditary angioedema (HAE) is a rare genetic disorder characterized by recurrent subcutaneous and submucosal swelli...

Allergy

Giavina-Bianchi P, Vazquez DO, Josviack D, Kaplan AP, Martinez PAS, Fantini CA, Bernstein JA, Martin BL, Ansotegui IJ, Craig TJ, Morais-Almeida M• October 27, 2026