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There was a mistake in Table 1 as published. The dietary caffeine intake is right-skewed, the median (interquartile range) is now reported instead of the mean ± SD: 73.00 (4.00, 192.00), 112.00 (26.00, 246.02), and 146.77 (49.70, 289.00) in the low-, middle-, and high-income groups, respectively. In addition, two values in the “Marital status” rows of the high-income group were transcribed incorrectly: “Separated” should read 40 (1.52%) rather than 296 (11.22%), and “Living with partner” should...
Background Prostate artery embolization (PAE) has emerged as a minimally invasive therapy which affords improvement in benign prostatic hyperplasia (BPH) symptoms and objective urinary parameters with a favorable adverse event (AE) profile. While PAE was recently included in the American Urological Association (AUA) Guidelines, guidance on its specific use-cases is limited. This study sought to answer remaining questions surrounding the safety and efficacy of PAE across different patient subpop...
Benign Prostatic Hyperplasia
Knight GM, Varadhan A, Benishay E, Rivera-Rodríguez DM, Jenkins K, Hohlastos E, Salem R, Mouli S•
Introduction: Syphilis has resurged across North America, including syphilis in pregnancy. Congenital syphilis can be prevented by timely treatment of syphilis in pregnancy, but conventional syphilis screening is problematic for people facing barriers to care. Syphilis point-of-care tests (POCT) have improved prenatal syphilis management in low- and middle-income countries. There is minimal literature regarding POCT feasibility and effectiveness for prenatal syphilis screening in high-income cou...
Syphilis
Njideka Sanya, Mary-Elizabeth Vaccaro, Medora Uppal, Sarah Glen, Chelsea Kirkby, Tehreem Zafar, Janet Gasparelli, Kate MacNeil, Stephanie Milliken, Jeffrey Pernica, Jacqueline Wong, Donald Brody Duncan, Marek Smieja, Amanda Ramdyal, Robin Lennox, Tim O’Shea, Anna Cvetkovic, Lawrence Mbuagbaw, Suzanne Turner, Laura Erdman•
Chronic obstructive pulmonary disease (COPD) is a complex and common condition with significant health, social, and economic burdens, especially due to frequent hospitalizations and comorbidities. International research shows current care for COPD is limited by delayed diagnosis, poor coordination among providers, and inconsistent adherence to treatment guidelines, which negatively impacts patient outcomes. Clinical pathways offer a promising solution by improving care coordination, aligning tre...
Copd
Kathrina Mazurik, Darcy D. Marciniuk, Erika Penz, Patricia Comfort, Alireza Ghorbani-Pashakolaei, Tracey-Ann Stitchell, Tracey Carr, Joshua Shitta, Amy Reid, Gill Westhorp, Collin Hartness, Jason Vanstone, Brenda Andreas, Maggie King, Kim Bell, Johnny Ahale, Ghazale Ahmadalitabar, Stacey McHenry, LUCID Project Team, Gary Groot•
Juvenile idiopathic arthritis (JIA) is the most common pediatric chronic inflammatory rheumatic condition, with substantial quality-of-life impacts. Treatment selection is complex due to limited guideline evidence, and difficult trade-offs. Decisions are often solely physician driven. We evaluated the feasibility of Large Language Model-based Decision Aid (LLM-DA) designed to support collaborative rather than solely physician decision-making in JIA care. A multi-method feasibility study was cond...
Arthritis
Antonia Barbaric, Susanne M. Benseler, Chitra Lalloo, Xinyi Celine Liu, Alex Mariakakis, Quynh Pham, Sebastiaan J. Vastert, Rae S. M. Yeung, Joseph A. Cafazzo, Joost F. Swart•
Background: Adults with congenital heart disease (CHD) may experience substantial psychological distress. This study evaluated whether a documented history of anxiety disorders is associated with a distinct psychosocial profile in adults with CHD. Methods: In this cross-sectional study, 45 adults with CHD were included: 21 with a documented history of anxiety disorders and 24 without. Psychosocial assessment included the EuroQol-5D-3L (EQ-5D-3L), Rosenberg Self-Esteem Scale (RSES), State–Trait A...
Anxiety
Efrén Martínez-Quintana, Marta Isabel García-Suárez, María Alcántara-Castellano, Jesús María González-Martín, Fayna Rodríguez-González•
Abstract Aim This single‐arm feasibility trial evaluated the feasibility and safety of a manualized outpatient Morita therapy (MT) program for patients with panic disorder (PD) and agoraphobia in routine psychiatric care, and explored preliminary signals of symptom change. Methods Ten outpatients with PD and agoraphobia were enrolled in a 12‐session manualized MT program. Feasibility outcomes included retention, attendance, and therapist adherence. Exploratory outcomes were the changes in sc...
Background Lower respiratory infection (LRI) remains an important cause of death and health loss in children younger than 5 years. We examined the residual global and Chinese under-5 LRI burden, vaccine-relevant pathogen inequalities, and the separate clinical-care needs of children hospitalized with pneumonia in China. Methods GBD and related public data were used to characterize under-5 LRI incidence, deaths, DALYs, SDI gradients, pathogen-attributed burden, and national Hib3 and PCV3 cover...
Lower Respiratory Infection
Su X, Liu D, Liu J, Lv D, Guo J, Hui Q, Ye F, Chen Y, Wang C, Tang L, Xia M, Zhang Q•
Background Pemphigus vulgaris (PV) may initially present with persistent oral erosions and can be mistaken for infectious or inflammatory mucosal disease. Case Description A previously healthy 43‐year‐old woman developed recurrent painful oral erosions that persisted despite multiple antifungal and antibacterial treatments. An initial biopsy from a necrotic oral ulcer was nondiagnostic. Following substantial oral improvement, she developed a generalized painful vesiculobullous eruption involv...
Attention-deficit/hyperactivity disorder (ADHD) is diagnosed primarily through clinical interviews, behavioral observations, and rating scales, while continuous performance tests (CPTs) provide complementary, performance-based measures of sustained attention, response inhibition, and response consistency. This narrative review compares major CPT paradigms used in pediatric ADHD assessment according to their cognitive targets, task characteristics, psychometric properties, ecological validity, cl...
Objective To establish reference ranges for the disturbance coefficient (DC) and edema coefficient (EC) in neonates without traumatic brain injury, based on head circumference, weight, and body length, to provide early warnings for neonatal brain injury. Methods Neonates were collected from the rooming-in unit of Northern Theater Command General Hospital, China, between June and December 2024. The non-invasive cerebral edema dynamic monitor was used to measure DC and EC at 24, 48, and 72 h af...
Edema
Wu B, Jia J, Qu D, Ma J, Xia Y, Li M, Zhu J, Yang M, Wei B•
Background Pseudo-pseudo Meigs syndrome (PPMS), or Tjalma syndrome, is a rare systemic lupus erythematosus (SLE)-associated phenotype characterized by ascites, pleural effusion, and elevated CA125 without an ovarian neoplasm. After assisted reproductive technology (ART), it may overlap with ovarian hyperstimulation syndrome (OHSS) or mimic gynecologic malignancy. Case presentation A 25-year-old woman underwent two controlled ovarian stimulation (COS) cycles for intracytoplasmic sperm injectio...
Systemic Lupus Erythematosus
Li S, Zhao D, Zhang M•
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