IFOSFAMIDE
NITROGEN MUSTARD DERIVATIVES · TESTICULAR GERM CELL TUMOR
Hikma Pharmaceuticals USA
Drug class
Nitrogen Mustard Derivatives
Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines. Read more about Nitrogen Mustard Derivatives
62 drugs in this class 45 manufacturers
Drugs in Nitrogen Mustard Derivatives
ALKERAN (melphalan HCl)
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA
APOPHARMA USA I
MELPHALAN HCL
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA
ATHENEX PHARMAC
MELPHALAN HCL
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA
MEITHEAL PHARMA
MELPHALAN HCL
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA
FOSUN PHARMA US
EVOMELA (melphalan HCl/betadex sulfobutyl ether sodium)
NITROGEN MUSTARD DERIVATIVES · CONDITIONING PRIOR TO AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANT
ACROTECH BIOPHA
ALKERAN (AS HCL) (melphalan HCl)
NITROGEN MUSTARD DERIVATIVES · MULTIPLE MYELOMA
APOPHARMA USA I
LEUKERAN (chlorambucil)
NITROGEN MUSTARD DERIVATIVES · HODGKIN'S LYMPHOMA ·+2
WAYLIS THERAPEU
HEPZATO (melphalan HCl)
NITROGEN MUSTARD DERIVATIVES · UNRESECTABLE HEPATIC METASTATIC UVEAL MELANOMA
DELCATH SYSTEMS
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Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines.
They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells.
Clinically represented by agents such as cyclophosphamide, chlorambucil, melphalan, ifosfamide, and bendamustine, this class is widely employed in oncology and hematology to treat leukemias, lymphomas, multiple myeloma, and various solid tumors, as well as serving key immunosuppressive roles in conditioning regimens for stem cell transplantation and severe autoimmune disorders.
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drugbank.com
Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines
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nih.gov
Nitrogen mustard derivatives are a foundational class of cytotoxic alkylating antineoplastic agents structurally derived from bis-(2-chloroethyl)amines They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells Clinically represented by agents such ...
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uni-regensburg.de
They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells
-
nih.gov
They exert their principal therapeutic effect by forming reactive aziridinium intermediates that covalently bind to DNA bases—chiefly guanine residues—producing intra- and inter-strand cross-links that disrupt replication and transcription, ultimately triggering apoptotic cell death in rapidly dividing cells
-
nih.gov
Clinically represented by agents such as cyclophosphamide, chlorambucil, melphalan, ifosfamide, and bendamustine, this class is widely employed in oncology and hematology to treat leukemias, lymphomas, multiple myeloma, and various solid tumors, as well as serving key immunosuppressive roles in conditioning regimens for stem cell transplantation and severe autoimmune disorders
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