Selective Serotonin 5-HT3 Antagonists

Selective serotonin 5-HT3 antagonists are a therapeutic class of medications that competitively inhibit type 3 serotonin (5-HT3) receptors located peripherally on gastrointestinal vagal afferents and centrally within the chemoreceptor trigger zone By blocking serotonin-mediated emetic signaling, these agents primarily serve as potent antiemetics to prevent and manage nausea and vomiting associated with cancer chemotherapy, radiation therapy, and surgical procedures

By blocking serotonin-mediated emetic signaling, these agents primarily serve as potent antiemetics to prevent and manage nausea and vomiting associated with cancer chemotherapy, radiation therapy, and surgical procedures

Additionally, specific agents in this class are utilized in gastroenterology to treat severe diarrhea-predominant irritable bowel syndrome by reducing colonic motility and visceral sensitivity

Additionally, specific agents in this class are utilized in gastroenterology to treat severe diarrhea-predominant irritable bowel syndrome by reducing colonic motility and visceral sensitivity