Indication

Adjuvant therapy following surgical resection of Kit (CD117) positive gastrointestinal stromal tumor

Kit (CD117)-positive gastrointestinal stromal tumors are mesenchymal neoplasms arising from the interstitial cells of Cajal within the digestive tract, most commonly in the stomach or small intestine. Read more about Adjuvant therapy following surgical resection of Kit (CD117) positive gastrointestinal stromal tumor

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Common Adjuvant therapy following surgical resection of Kit (CD117) positive gastrointestinal stromal tumor therapies.

Showing 10–18 of 28 drugs

IMATINIB MESYLATE

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
ASCEND LABORATO

IMATINIB MESYLATE

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
Hikma Pharmaceuticals USA

IMATINIB (imatinib mesylate)

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
ARMAS PHARMACEU

IMATINIB MESYLATE

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
AREVA PHARMACEU

IMATINIB MESYLATE

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
GSMS, INC.

IMATINIB MESYLATE

ANTINEOPLASTIC - PROTEIN-TYROSINE KINASE INHIBITORS·PHILADELPHIA CHROMOSOME POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA·+11
CHARTWELL RX LL
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About Adjuvant therapy following surgical resection of Kit (CD117) positive gastrointestinal stromal tumor.

Kit (CD117)-positive gastrointestinal stromal tumors are mesenchymal neoplasms arising from the interstitial cells of Cajal within the digestive tract, most commonly in the stomach or small intestine.

Pathophysiologically, these tumors are characterized by cell-surface expression of the CD117 antigen, typically driven by activating mutations in the *KIT* proto-oncogene receptor tyrosine kinase that promote uncontrolled cellular proliferation.

In this post-surgical clinical state, patients who have undergone complete gross surgical resection of the primary tumor face a variable risk of disease recurrence depending on tumor size, mitotic rate, location, or tumor rupture.

Adjuvant therapy is indicated in this setting to eradicate residual micrometastatic disease and reduce the risk of relapse.

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