Indication
Pemphigus
Pemphigus refers to a group of rare, chronic, life-threatening autoimmune blistering diseases that target stratified squamous epithelia, including the epidermis and mucous membranes. Read more about Pemphigus
335 drugs 162 manufacturers
Drugs that treat it
Common Pemphigus therapies.
DEXAMETHASONE
DEXAMETHASONE
CORTISONE ACETATE
DEXAMETHASONE SODIUM PHOSPHATE
PREDNISONE
SOLU-MEDROL (methylprednisolone sodium succinate)
METHYLPREDNISOLONE
METHYLPREDNISOLONE
News & literature
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Coming soonPemphigus refers to a group of rare, chronic, life-threatening autoimmune blistering diseases that target stratified squamous epithelia, including the epidermis and mucous membranes.
It primarily affects adults and is characterized pathophysiologically by pathogenic IgG autoantibodies directed against desmogleins—principally desmoglein 1 and desmoglein 3—which are vital cell-to-cell adhesion molecules within desmosomes.
This autoimmune attack induces acantholysis, or the detachment of neighboring keratinocytes, resulting in intraepithelial clefting.
Clinically, this process manifests as fragile, flaccid bullae and extensive, painful mucosal and cutaneous erosions that leave patients susceptible to severe fluid loss and secondary systemic infections.
- nih.gov
Pemphigus refers to a group of rare, chronic, life-threatening autoimmune blistering diseases that target stratified squamous epithelia, including the epidermis and mucous membranes It primarily affects adults and is characterized pathophysiologically by pathogenic IgG autoantibodies directed against desmogleins—principally desmoglein 1 and desmoglein 3—which are vital cell-to-cell adhesion molecules within desmosomes This autoimmune attack induces acantholysis, or the detachment of neighboring ...
- nih.gov
Pemphigus refers to a group of rare, chronic, life-threatening autoimmune blistering diseases that target stratified squamous epithelia, including the epidermis and mucous membranes
- mayoclinic.org
Clinically, this process manifests as fragile, flaccid bullae and extensive, painful mucosal and cutaneous erosions that leave patients susceptible to severe fluid loss and secondary systemic infections
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