Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disorder causing structural spinal damage and pathological thoracic kyphosis. Accurate quantification of spinal curvature is crucial for monitoring disease progression and guiding treatment. Conventional Cobb angle measurement on radiographs or DEXA images is widely used but is time-consuming and prone to inter-observer variability. This study evaluates an automated deep learning-based approach using a You Only Look Once (YOLO) model for...
ABSTRACT Background The Australasian Society of Clinical Immunology and Allergy (ASCIA) Guideline: Infant Feeding for Food Allergy Prevention is an update of the 2016 ASCIA guideline. This updated guideline provides recommendations specifically in relation to infant feeding for food allergy prevention. Methods A review of the guideline began in 2024, informed by a systematic evidence review process and using the Appraisal of Guidelines for Research & Evaluation II (AGREE II) framework. Where...
Allergy
Vale SL, Netting MJ, Hornung CJ, Smith J, Roche I, McWilliam V, Hollinshead K, South C, Young A, Rueter K, Perrett KP, Palmer DJ, Joshi P, Campbell DE, Koplin JJ, Ford LS•
ABSTRACT Background A label of betalactam (BL) allergy is estimated in around 10% of the population in their medical records. Second‐line choices carry significant negative consequences, including reduced efficacy, effectiveness, and safety. This study aimed to develop a new highly specific score constructed by selecting variables assisted by artificial intelligence to identify low‐risk BL‐allergic patients. Methods In this study, derivation and validation of the BL‐predictor score were perf...
Allergy
Labella M, Nuñez R, Doña I, de Guzmán JR, Moreno E, Garvey LH, Laguna JJ, Barbaud A, Bonnadona P, Boel JB, Mosbech H, Sfriso G, Castells M, Phillips E, Torres MJ•
Parasitic infections are increasingly recognized as contributors to cancer development, yet the underlying oncogenic mechanisms remain insufficiently understood. Growing evidence from molecular oncology, immunology, and microbiome research suggests that chronic parasitic infections may drive tumorigenesis through sustained inflammation, deregulated signaling pathways, genomic instability, and the release of parasite-derived exosomes that reshape the tumor microenvironment. These insights undersc...
Parasitic Infections
Pawłowska M, Jarek D, Milanowski J, Szewczyk-Golec K•
Objective: To compare seizure outcomes during pregnancy in women with epilepsy (WWE) by history of catamenial patterns. Background: Catamenial patterns are defined as increased seizure frequency during certain phases of the menstrual cycle (perimenstrual, peri-ovulatory, or luteal in anovulatory cycles). Animal studies suggest seizure improvement occurs with higher progesterone and allopregnanolone concentrations and lower estrogen concentrations. Prior human studies also reported that WWE wi...
Pregnancy
Osterhaus EC, French JA, Jain R, Kerr WT, Pennell PB•
Background Nearly 1 in 4 Americans experience chronic nasal congestion on a daily basis. For those that present to an otolaryngologist's office, nasal congestion or obstruction can be due to a wide variety of etiologies, with many resulting from an inflammatory, infectious, or anatomic cause, though commonly a combination. A first line treatment used to treat nasal congestion is often an intranasal corticosteroid (INCS) spray, but given the abundance of INCS sprays at the otolaryngologist's dis...
Background The CD3xCD20 bispecific antibody epcoritamab demonstrated deep, durable responses with manageable safety in relapsed/refractory (R/R) follicular lymphoma (FL) in EPCORE NHL-3 (phase 1/2; NCT04542824). This analysis evaluated 3-year follow-up outcomes in Japanese patients. Methods Adults with CD20 + FL and ≥ 2 prior lines of therapy (LOTs) received subcutaneous epcoritamab (0.16/0.8-mg step-up doses; 48-mg full doses) until disease progression or death. The primary endpoint was over...
Follicular Lymphoma
Izutsu K, Akahane D, Toubai T, Saito T, Mishima Y, Fujisaki T, Nishikori M, Kumode T, Suehiro Y, Ishitsuka K, Patah P, Takahashi A, Månsson BD, Favaro E, Fukuhara N•
Background Spring coil migration is a rare cause of gastrointestinal bleeding and a rare, delayed complication of arterial embolization. There is no consensus on the treatment of gastrointestinal bleeding due to coil migration. We present the case of a 70-year-old Chinese male who experienced duodenal ulcer bleeding caused by coil migration and recovered well after undergoing open surgery. Case presentation A 70-year-old Chinese male was admitted to the department of gastroenterology with com...
Objectives We sought to understand barriers to high-quality hospital-based child acute lower respiratory infection (ALRI) care at Mchinji District Hospital in Malawi. Methods In 2020, we conducted focus group discussions (FGDs) with clinical officers (COs) who provided direct clinical care after a half-day refresher course on pediatric ALRI case management. The underpinning research methodology of the FGDs was phenomenology, and they were analyzed using inductive and deductive thematic analys...
Lower Respiratory Infection
Hooli S, Zadutsa B, Phiri E, Hofstee K, Davis N, McCollum ED, Makwenda C, King C•
Background/Objective: Maxillary canine impaction is a frequent orthodontic challenge. Three-dimensional CBCT assessment allows precise evaluation of periradicular bone density, which may play a role in eruption failure. This study aimed to compare bone density (HU) around impacted canines with that of the contralateral erupted tooth and to assess correlations with age and sex. Methods: A total of 26 patients (10 males, 16 females; 13–19 years) with unilateral maxillary canine impaction were exam...
Introduction Lumbar CT and MRI scans are helpful for osteoporosis (OP) screening. Deep learning enhances the efficiency and accuracy of musculoskeletal quantification for OP screening. Objectives To develop a deep learning-based model (UNet3D) for musculoskeletal quantification from lumbar CT and MRI in OP patients, and to explore musculoskeletal relationship. Materials Retrospectively analyzing OP patients’ lumbar CT, MRI and DXA scans between January 2018 and August 2025 from two center,...
Osteoporosis
Guan Z, Wang Y, Zhang S, Zhang Y, Wang L, Chen Y, Lu X•
ABSTRACT Objective To examine the efficacy of cervical physical therapy (e.g. cervical mobilization, exercise, and myofascial treatments) on pressure pain thresholds (PPTs) in patients with migraine, compared to no treatment, sham treatment, or usual medical care. Method A systematic search was performed in PubMed, Embase.com, Web of Science, SPORTDiscus, Cinahl Plus and PEDro. Two independent reviewers assessed the selected randomized controlled trials (RCTs). The risk of bias was assessed...
Migraine
Amons AL, Castien RF, De Hertogh W, Burchell GL, Schoonmade LJ, van der Wouden JC, Dekker J, van der Horst HE•
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