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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,765–1,776 of 2,098 articles

PubMed

Yeast chemical genetics to investigate mechanism of action of Pacific natural products.

Abstract Natural products are a major source of bioactive molecules with important applications in medicine, and investigation of species native to the Pacific region has been particularly fruitful, including species used in traditional and Indigenous medicinal practices. Yeast represents a powerful model system for investigating mechanisms of action and other cellular processes; however, its use in natural product research is often limited to growth inhibition or cytotoxicity assays, with unde...

Articles
Ooi RJ, Robinson HF, Pay R, Bircham PW, Keyzers RA, Atkinson PH, Munkacsi AB•
PubMed

Global Burden of Cancer Attributable to Metabolic Risk Factors among Adults Aged 20-49 Years, 1990-2021, with Projections to 2040.

Background Early-onset cancers (diagnosed in individuals under 50 years of age) are increasingly contributing to the global cancer burden. Among the known contributors, specific metabolic risk factors—namely high body mass index (BMI) and high fasting plasma glucose (FPG)—have emerged as significant determinants. This study assessed global cancer-related burden attributable to these two metabolic risk factors among persons aged 20–49 years and projected their trends through 2040. Methods Usin...

Articles
Qiao W, Zhou K, He L, Guo J, Guo Q, Zhang J, Li Y•
PubMed

Distinct treatment response trajectories to allergen immunotherapy in allergic asthma and rhinitis: Insights from a multicenter study in routine clinical practice.

Background While allergen-specific immunotherapy (AIT) is recognized as an effective treatment, its efficacy varies widely. However, whether clinical response trajectories to AIT differ among individuals and influence its effectiveness has not been investigated. Objective This study aimed to characterize real-world clinical response trajectories to three-year AIT (3y-AIT). Methods We conducted a retrospective multicenter study across 53 centers to identify clinical response trajectories in...

Articles
Zhang P, Qin R, Zhang W, Yang Y, Li H, Dong X, He Y, Wang H, Chen Z, Chen L, Wu J, Bao Y, Tian M, Tan G, Ye J, Jin M, Liang Y, Xu K, Mao L, Lv Q, Zhang Y, Wang W, Li J•
PubMed

Comparison of Lidocaine and Dexmedetomidine in Preventing Fentanyl-induced Cough in Patients Undergoing Elective Surgery: A Blinded Randomized Controlled Trial.

Background Fentanyl-induced cough (FIC) refers to a cough that can occur as a side effect of fentanyl, an opioid analgesic primarily used for pain management. Both lidocaine (LIDO) and dexmedetomidine (DEX) are effective in preventing FIC, but the comparative efficacy of each has not yet been thoroughly investigated. Objectives In this study, we aimed to compare the effect of LIDO versus DEX in preventing FIC in adult patients undergoing elective surgery. Methods A total of 171 adult patien...

Articles
Jarineshin H, Zarezadeh H, Ghazizadeh S, Mahmoudi M, Taherzadeh F, Vatankhah M•
PubMed

Refractory Kawasaki Disease With a Coronary Artery Aneurysm in a Three-Month-Old Infant: Diagnostic Challenges and Rescue With Infliximab.

Kawasaki disease (KD) is an acute systemic vasculitis and the leading cause of acquired heart disease in children. Diagnosis is particularly challenging in early infancy due to incomplete presentations. We describe a three-month-old infant with persistent fever, irritability, and lymphadenopathy who was initially treated for bacterial infection. By Day 7, the patient developed conjunctivitis, cracked lips, and pharyngeal congestion, meeting criteria for incomplete Kawasaki disease. Laboratory f...

Articles
Nernji DH, Elhuni E, Al Jashmi R, Atiq A•
PubMed

Clinical Efficacy of Early and Late Vedolizumab or Infliximab Interventions in Moderate Ulcerative Colitis: A Multicenter, Retrospective Cohort Study.

Background Late biologic intervention has been partly displaced during the last decade by early biologic therapy. However, there is a scarcity of direct evidence to inform clinical decision-making with greater confidence. The study aimed to compare the efficacy and safety of the early biologic approach with those of the late biologic approach in patients with moderate ulcerative colitis (UC). Methods Moderate UC patients treated with biologics between January 2021 and February 2024 from three...

Articles
Meng RP, Zhang J, Wei HQ, Liao XP, Liu E, Lin H, Huang BB, Lyu L, Wei YL, Zhou JY, Xie X•
PubMed

Phase II study of the triple combination of rabbit ATG, ciclosporin and eltrombopag in patients with transfusion-dependent aplastic anaemia: West Japan Hematology Study Group (W-JHS) AA02 trial.

Summary The efficacy of a triple combination of rabbit anti‐human thymocyte immunoglobulin (rATG), ciclosporin and eltrombopag (EPAG) was prospectively evaluated in patients with severe or transfusion‐dependent non‐severe aplastic anaemia (SAA) across 29 institutions in Japan. Sixty patients were enrolled, of whom 48 had SAA. The primary end‐point, the haematological overall response rate at 12 weeks, was 52.6% (95% confidence interval, 39.0%–66.0%), increasing to 67.9% at 26 weeks. The most fr...

Articles
Nakamura F, Ishiyama K, Suzuki R, Maruyama H, Onishi Y, Usuki K, Koh H, Takenaka K, Saiki R, Ogawa S, Matsumoto K, Takahashi T, Hosomichi K, Zaimoku Y, Yoshimura K, Matsumura I, Akashi K, Nakao S•
PubMed

Diagnostic Efficiency in Urinary Tract Infection: Evaluation of a Comprehensive Intervention Based on Clinical Conditions, Urinalysis, and Gram Staining.

Introduction: Urinary tract infection (UTI) is the second most common cause of infection globally, following respiratory system infections. The aim is to evaluate the effectiveness of an optimization strategy in the diagnosis of UTIs through the patient’s clinical condition and laboratory tests, with the purpose of reducing unnecessary urine culture processing, reducing antibiotic treatment of asymptomatic bacteriuria, and improving the diagnostic accuracy of UTIs. Methods: A quasi-experimental...

Articles
Solórzano C, Rubio MC, León JL, Caro MA, Olarte Licht LA, Luna Gualdron JM, Manrique-Hernandez EF, Licht-Ardila M, Hurtado Ortiz A•
PubMed

Changes to Weight Bias Internalization and Eating Behaviors in Adults Aged 50+ With Overweight or Obesity During a Structured 12-Week Behavioral Weight Management Intervention.

ABSTRACT Background Weight stigma is a prevalent issue among individuals with overweight and obesity pursuing weight loss; however, few studies have examined this issue in middle‐aged and older adults. Treatment‐seeking populations may also be at risk of disordered eating or excess concern about weight and shape; thus, it is important to evaluate how these parameters may change over the course of a weight loss intervention. Methods Adults aged 50+ (n = 83; 60 F, 23 M) completed measures of e...

Articles
Howes E, Howard KR, Laskaridou E, Parker M, D'Angelo A, Warnock J, Heidary C, Lambert S, Thakur V, Davy BM•
PubMed

Challenges in the Classification of Cardiac Arrhythmias and Ischemia Using End-to-End Deep Learning and the Electrocardiogram: A Systematic Review.

Background: Cardiac arrhythmias and ischemia are increasingly problematic worldwide because of their frequency, as well as the economic burden they confer. Methods: This research presents a systematic literature review (SLR), based on the PRISMA 2020 statement, that looks into the difficulties in their classification using end-to-end deep learning (DL) techniques and the electrocardiogram (ECG) from 2019 to 2025. A total of 121 relevant studies were identified from Scopus, Web of Science, and IE...

Articles
Oporto E, Mauricio D, Maculan N, Uribe G•
PubMed

Bacterial pharyngitis, antimicrobial susceptibility, and associated factors among children at comprehensive specialized hospitals, Northwest Ethiopia.

Background Bacterial pharyngitis is a common childhood infection involving inflammation of the pharynx and tonsils. Compared to viral causes, it often presents more severely and can result in complications if untreated. However, data on its bacterial etiology, resistance patterns, and associated risk factors are limited in developing countries, including Ethiopia. Objective To assess the prevalence, bacterial causes, antimicrobial susceptibility patterns, and risk factors of pharyngitis among...

Articles
Mihrete K, Awoke T, Melake A, Sisay T, Abera B•
PubMed

Vanishing Bile Duct Syndrome as a Rare Complication of Classic Hodgkin's Lymphoma: A Case Report and Literature Review.

Vanishing bile duct syndrome (VBDS) is an acquired condition of progressive intrahepatic bile duct loss, resulting in severe cholestasis. Here, we present a case of VBDS in a patient with newly diagnosed classic Hodgkin's lymphoma (cHL). Our patient presented with cholestatic liver test elevations, including bilirubin and alkaline phosphatase. Liver biopsy confirmed the paucity of bile ducts and did not show involvement by lymphoma. Though the exact pathophysiology is unclear, it is postulated t...

Articles
Tai JW, Shah VD, Harmon RL, Chandna S, Yan J, Fathizadeh P, Beaven S, Karunasiri D, Kim P•