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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,933–1,944 of 2,098 articles

PubMed

The Mechanism of Icariin in Regulating BMSCs for Treating Osteoporosis: A Review.

Introduction Osteoporosis (OP) is a common skeletal disease mainly caused by the imbalance between bone formation and bone resorption. Dysfunction and senescence of bone marrow mesenchymal stem cells (BMSCs) are critical pathogenic factors for OP, resulting in impaired osteogenic differentiation, increased adipogenic shift, and enhanced susceptibility to inflammation and oxidative stress. Therefore, the purpose of this review is to systematically synthesize current evidence on how Icariin (ICA)...

Articles
Wang C, Wu Z, Xu Y, Li Y, Man Z, Liu K, Wang J, Lin W, Qie F, Shi X, Yuan Y•
PubMed

Bone Marrow Mesenchymal Stem Cell Senescence in the Development of Osteoporosis: Mechanisms, Interventions, and Future Directions.

Osteoporosis, a significant age-related disease, is marked by diminished bone density and an elevated risk of fractures, representing a considerable global health challenge. Bone marrow mesenchymal stem cells (BMSCs) are essential in maintaining bone integrity through their differentiation into osteoblasts, which are crucial for bone formation. Nevertheless, the aging of BMSCs diminishes their regenerative abilities and intensifies inflammation, thereby playing a critical role in osteoporosis pa...

Articles
Li C, Li B, Zhang J, Liu K, Du G, Guo C, Yang Z•
PubMed

The Patent Landscape of AI-Based Imaging Diagnostics for Osteoporosis: A Scoping Review.

Background Osteoporosis is a widespread skeletal disorder characterized by reduced bone density and increased fracture risk. Early detection is critical to preventing disability and healthcare burden. Methods A systematic search was conducted in Google Patents for documents filed between June 2022 and June 2025 that applied artificial intelligence or machine learning to osteoporosis detection using X-ray imaging. Patents were screened in three stages by independent reviewers according to pred...

Articles
Feng Z, Wu S, Wang X, Lou L, Liu X, Chai Y•
PubMed

Multimodal Osteoporosis Assessment using X-ray Imaging and Clinical Data with a Hybrid Deep Learning Model.

Introduction/Background Osteoporosis is a systemic skeletal disorder characterised by low bone mass. The classification typically includes three stages: normal, osteopenia, and osteoporosis. Early detection is essential for effective treatment and reducing fracture risk. This detection is possible through X-ray imaging and clinical assessments, such as measuring T-score and SoS, etc. This study aims to enhance the accuracy of osteoporosis assessment by combining both imaging and clinical data u...

Articles
Pappathi NA, Sakthivel B, Abdullah S S•
PubMed

Integrating Shared Decision-Making, Motivational Interviewing, and Health Coaching in Obesity Care: A Stage-Based Conceptual Framework for Sustainable Behavior Change.

Background Obesity is a chronic, multifactorial disease that requires sustained modification of health behaviors. Although effective behavioral, pharmacological, and surgical treatments are available, long‐term weight loss maintenance remains challenging. Shared decision‐making (SDM), motivational interviewing (MI), and health coaching (HC) have been studied as patient‐centered approaches that may support communication, decision‐making, motivation, and engagement. However, their impact on behav...

Articles
Domosławska-Żylińska K, Olejniczak D, Włodarczyk D•
PubMed

Glucagon-like Peptide-1 Receptor Agonists in Treating Diabetes Mellitus and Weight Loss with Potential Application to Rare Obesity-related Genetic Disorders: A Commentary.

Background Glucagon-like peptide-1 (GLP1) and receptor (GLP1R) agonists are now in common use for treating type 2 diabetes mellitus and weight loss as major global health burdens affecting millions worldwide with prevalence of both diagnosed and undiagnosed diabetes approaching 15% for all U.S. adults increasing with age (www.cdc.gov/diabetes/php/data-research/index.html). More than two in five U.S. adults have obesity (www.cdc.gov/obesity/adult-obesity-facts/index.html) along with a growing nu...

Articles
Francis L, Butler MG•
PubMed

Effects of Acupuncture on Cerebral Blood Flow in Episodic Migraine Patients Investigated by Arterial Spin Labeling MRI.

Objective To investigate the temporal dynamics of cerebral blood flow (CBF) responses to Japanese‐style acupuncture in patients with episodic migraine using arterial spin labeling (ASL) magnetic resonance imaging (MRI) and to compare these responses with those of healthy controls. Methods Patients with episodic migraine were recruited according to the International Classification of Headache Disorders, 3rd edition (ICHD‐3), and healthy volunteers without migraine served as controls. Japanese‐...

Articles
Kikuchi T, Yamaguchi S, Matsuda H, Tsuchiya K, Araki N•
PubMed

Awareness and Prescribing Patterns of Acute and Preventive Migraine Medications Among General Practitioners: The Kawasaki Medical Association Study.

Aim In Japan, the introduction of anti‐calcitonin gene‐related peptide (CGRP) monoclonal antibodies and the 5‐HT1F receptor agonist lasmiditan has transformed migraine treatment. However, medical consultation and prescription rates for migraine remain low. This study aimed to clarify the awareness and prescribing patterns of acute and preventive migraine medications among physicians in Kawasaki, Japan. Methods A questionnaire survey of 1274 physicians registered with the Kawasaki Medical Asso...

Articles
Akiyama H, Ono H, Komine Y, Nakano Y, Yamano Y•
PubMed

Iron-Sensitive MRI Reveals Individual Differences in Pain Modulation Rather Than Categorical Markers in Chronic Pain and Migraine.

Objective To determine whether regional iron levels are associated with endogenous pain‐inhibitory function and whether iron‐sensitive MRI techniques, quantitative magnetic susceptibility (QSM) and R2∗ mapping capture differences in midbrain iron content in the globus pallidus (GP), periaqueductal grey (PAG), and red nucleus (RN) across chronic pain (CP), migraineurs (M), and healthy volunteers (HV). Methods Sixty participants (20 CP, 20 M, and 20 HV) underwent a 3T MRI examination. Pain modu...

Articles
Ydlibi O, Salehi Ravesh M, Bernerth F, Maedler B, Jansen O, Gierthmühlen J, Peters S•
PubMed

Transcranial Photobiomodulation Attenuates Neurogenic Inflammation and Sensory Hypersensitivity in a Nitroglycerin-Induced Migraine Model: Toward a Nonpharmacological Therapy.

Background Migraine is a debilitating neurological condition, characterized by headache, photophobia, and heightened mechanical/thermal sensitivity. Current pharmacological therapies often lead to incomplete relief and adverse effects, necessitating the use of noninvasive alternatives. This study evaluated transcranial photobiomodulation (PBM) in a nitroglycerin (NTG)‐induced migraine model in male mice. Methods Mice were assigned to Sham, NTG, NTG + Sumatriptan (SUMA; 600 µg/kg, s.c.), NTG +...

Articles
Kazmi S, Vatandoust SM, Athari SZ, Ebrahimian A, Moradi A, Mahmoudi J, Sadigh-Eteghad S, Rajabi M, Akhbari-Shojaei S, Neshan-Alipour R, Nozad A, Hosseinkhani M, Hosseini L, Hamblin MR, Farajdokht F•
PubMed

Body Mass Index Protects Against Temporomandibular Disorders, Whereas Systemic Inflammation, Vitamin D, and Migraine Do Not: A Causal Inference Study.

Background and Objectives Observational studies link temporomandibular disorders (TMDs) with body mass index (BMI), vitamin D, C‐reactive protein (CRP), and migraine but causal relationships remain unclear. This study aimed to assess the bidirectional causal effects between these factors and TMD using Mendelian randomization (MR). Materials and Methods We used publicly available GWAS summary statistics. TMD data were from FinnGen R13 (23,035 cases; 477,151 controls). Exposure data for BMI, vi...

Articles
Yu M, Dai L•
PubMed

Menopause and Muscle: Closer to Answers, but Significant Questions Remain.

The review by Menzies, Bowtell, Shur and Brook arrives at exactly the right moment [1]. For years, menopause has been framed, sometimes breathlessly, as a musculoskeletal ‘breaking point’ that inevitably triggers rapid skeletal muscle loss. In contrast, this review does something far more valuable. It slows the narrative down, puts human data first and makes a compelling case that our certainty about muscle loss in menopause has outrun the evidence [1]. Their central contribution is not a single...

Articles
Phillips SM•