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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,945–1,956 of 2,098 articles

PubMed

Retrospective Case Series of Ocular Lyme Disease, 1988-2025.

Reports of ocular manifestations of Lyme disease (LD) are uncommon, and signs and symptoms may be overlooked by physicians. We conducted a retrospective case series of ocular LD reported during 1988–2025. Among 27 published reports in PubMed, we noted that, in 38 cases, the most common ocular manifestation was uveitis, representing 45% of cases, followed by optic neuritis and cranial nerve palsies (including trochlear and abducens). Not all cases met Centers for Disease Control and Prevention su...

Articles
Bellafiore J, Mahrous A, Gurumurthy V, Capitle E, Schutzer SE•
PubMed

Advancing Diagnostic Accuracy in Liver Cancer: A Systematic Review of Artificial Intelligence Applications in Hepatocellular Carcinoma and Cholangiocarcinoma Detection Using Abdominal CT Imaging.

Objective: This study aimed to systematically evaluate the diagnostic performance of artificial intelligence (AI) in differentiating hepatocellular carcinoma (HCC) from cholangiocarcinoma (CCA) using abdominal CT and MRI, with an emphasis on its clinical implications for liver cancer management. Methods: Following the PRISMA guidelines, we conducted a comprehensive literature search across five major databases (PubMed, Web of Science, ScienceDirect, Scopus, and Google Scholar) from 2000 to Ma...

Articles
Rattanapitoon SK, Arunsarn P, Meererksom T, Thanchonnang C, Boonsuya A, Phinsiri S, Nomsungnoen P, Pongseeda P, Keeratibharat N, Chansangrat J, Pechdee P, Rattanapitoon NK•
PubMed

Elevated Liver Enzymes and Genotype I of T. gondii Among Liver Cancer Patients: Evidence of a Potential Link.

Objective: Toxoplasma gondii is an intracellular protozoan that may disrupt the traditional cell barriers against cancer, allowing the accumulation of oncogenic mutations over time. Our research aimed to explore the relationship between T. gondii infection and liver cancer development. Methods: The present study, conducted in the city of Nasiriya, Iraq, involved 80 blood samples collected from individuals aged 18 to 70 years, of both sexes. The samples were divided into two groups: 40 from pa...

Articles
Jasim NH, Al-Waaly ABM•
PubMed

CTH Promotes Liver Cancer Progression and Exploratory Evaluation Supports Enhanced Antitumor Activity of PPG Plus GPC3 CAR-T Cells.

Although hydrogen sulfide (H2S) is a key regulator in cancer biology, the mechanism by which the H2S‐producing enzyme cystathionine‐γ‐lyase (CTH) functions in hepatocellular carcinoma (HCC) remains elusive. Using the slow‐releasing H2S donor GYY4137, we observed enhanced migration and invasion in HuH7 and HepG2 cells. Subsequently, we observed consistent protumorigenic effects of CTH not only in vitro but also in subcutaneous and orthotopic mouse models. Here, our findings suggest that CTH‐H2S s...

Articles
Guo Y, Yu M, Zhu X, Li W, Liu Y, Wu X•
PubMed

Correction to "Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones".

B. Wang, J. Wei, Q. Huangfu, F. Gao, L. Qin, J. Zhong, J. Wen, Z. Ye, X. Yang, and H. Liu, “Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones,” Oxidative Medicine and Cellular Longevity, 2022, https://doi.org/10.1155/2022/4345037. In the article, the authors have identified an error in which the incorrect number of participants was stated throughout the article. The correct number of participants is 40 controls and 31 kidney stone patients...

Articles
PubMed

Daridorexant and Insomnia in Clinical Practice: A Nominal Group Technique Consensus Study among Italian Sleep and Insomnia Experts.

Introduction Chronic insomnia disorder significantly affects cognitive, emotional, and physical health. Recently, the dual orexin receptor antagonist (DORA) daridorexant was approved for treating chronic insomnia in several countries. Given the limited evidence available, expert consensus was sought to clarify key clinical issues, inform practice, and guide future research. Methods Thirteen Italian sleep experts employed the Nominal Group Technique (NGT) to identify and rank important clinica...

Articles
Ferini-Strambi L, Arnaldi D, Bonanni E, Cicolin A, Gigli GL, Liguori C, Lombardi C, Parrino L, Provini F, Puligheddu M, Romigi A, Silvestri R, Palagini L•
PubMed

Psychological Factors, Central Sensitization, and Insomnia as Potential Prognostic Factors for Short-Term Pain and Disability in Patients With Frozen Shoulder: A Multicentric Prospective Single-Cohort Study.

Background Identifying modifiable prognostic factors is essential for personalizing conservative interventions. Several psychological and systemic variables remain underexplored in the frozen shoulder (FS) population, particularly regarding their prognostic relevance for short‐term changes in pain and disability. Aim To estimate the prognostic value of psychological factors, central sensitization, and sleep disturbances in predicting clinical outcomes after 3 months of standardized conservati...

Articles
Brindisino F, Silvestri E, Fioretti A, Pulina F, Conteduca J, Navarro Ledesma S, Barbosa GM, Struyf F•
PubMed

Mendelian Randomization Research Examining the Effects of Insomnia on Herpes Zoster and Postherpetic Neuralgia.

Background Insomnia is closely linked to herpes zoster (HZ) and postherpetic neuralgia (PHN); nonetheless, the causal relationship has not been sufficiently clarified. This research employs the Mendelian randomization (MR) method to investigate the causal relationship between insomnia and HZ, as well as PHN. Methods Summary statistics from publicly available GWASs were utilized for four sleep traits (insomnia, sleep duration, habitual short sleep [< 7 h/day], and habitual long sleep [≥ 9 h/da...

Articles
Yang X, Li X, Lin J, Chen Y, Zhang X, Zhao Q•
PubMed

High Anemia Awareness Does Not Mitigate Insomnia Risk in Ghanaian University Students: A Cross-Sectional Study.

Background Anemia and insomnia represent significant public health concerns among university students. However, their interrelationship and the potential role of anemia prevention knowledge in mitigating these conditions remain unexplored in Ghanaian tertiary institutions. Aim This study determined the prevalence of anemia and insomnia among Ghanaian university students. Likewise, the knowledge, attitudes, and practices regarding anemia prevention and the association between anemia prevention...

Articles
Agyapong L, Apreku JB, Acheampong I, Kpeglo G, Ansaful ONK, Sagoe E, Dadzie CE, Sirbah AC, Yusif MA, Apalebilah S, Owusu G, Donkor DM, Siame D, Boachie J•
PubMed

The association of left atrial volume index and coronary artery disease in type 2 diabetic patients without a history of hypertension and valvular heart disease.

BACKGROUND: Left atrial volume index (LAVI) evaluated using echocardiography serves a powerful predictor of cardiovascular outcomes. Since type 2 diabetes mellitus (T2DM) is a main risk factor for coronary artery disease (CAD), the present investigation was conducted to examine the association between LAVI and incidence of CAD in diabetic patients. METHODS: In this case-control study, 90 type 2 diabetic patients aged 18–70 years who underwent coronary angiography at Imam Hossein Hospital, Teh...

Articles
Mahjoob MP, Sadeghi R, Haji Aghajani M, Omidi F, Rostamnezhad M, Salehi M•
PubMed

Efficacy of recombinant growth hormone therapy in children born small for gestational age (SGA): a retrospective analysis.

Introduction Children born small for gestational age (SGA) present with a birth weight or length below –2 standard deviations (SD) relative to population norms for gestational age and sex. In Poland, such patients are eligible for recombinant human growth hormone (rhGH) therapy reimbursed by the National Health Fund. Aim of the study To retrospectively assess the effectiveness of rhGH therapy in children diagnosed with SGA based on clinical data from 39 patients treated with rhGH between 2016...

Articles
Pałysa A, Kopiec-Burdecka M, Pyrżak B•
PubMed

Sex Hormone-Based Models Outperform Conventional Scores for Metabolic Dysfunction-Associated Steatotic Liver Disease Screening: A Sex-Specific Analysis in Type 2 Diabetes.

Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is highly prevalent among patients with Type 2 diabetes mellitus (T2DM). Although various noninvasive assessment tools for MASLD are currently available, few have been specifically validated in T2DM populations. Furthermore, the role of sex hormones in MASLD and their potential influence on cardiovascular and renal outcomes remain incompletely understood. Methods In this cross‐sectional study of 731 Chinese patients w...

Articles
Li G, Liu W, Chen R, Guo J, Wang L•