Sign in Register

Clinical intelligence & editorial.

Advertisement

Advertisement

Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,957–1,968 of 2,098 articles

PubMed

Genetics and reproduction in buffalo: latest insights into the genetic architecture of reproductive traits.

Buffaloes are integral to the agricultural economies of numerous countries, providing essential contributions to milk and meat production, as well as draught power. Fertility in buffaloes is a complex quantitative trait that significantly affects both production and economic efficiency. Therefore, elucidating the genetic architecture underlying reproductive traits in buffaloes is critical for the development of sustainable breeding programs aimed at enhancing reproductive performance. This revie...

Articles
Zhou J, Liu C, Feng W, Deng T, He H, Yang H, Yang L, Liang A•
PubMed

Pompe Disease: A Review of Diagnosis, Molecular Genetics, and Treatment Management.

Introduction Pompe disease, a rare autosomal recessive lysosomal storage disorder, results from mutations in the GAA gene that lead to deficient acid alpha-glucosidase activity and glycogen accumulation in various tissues. Methods This review employs the diagnostic approach to the disease, encompassing enzymatic assays and molecular genetics, with a focus on genotype-phenotype correlations and region-specific mutations. Results Over 500 mutations in the GAA gene, including missense, nonsens...

Articles
Adadi N, El Brouzi MY•
PubMed

Identifying Novel Biomarkers and Therapeutic Targets for Endometriosis: Integrative Analysis of the Plasma Proteome and Genome.

Background There is currently no consensus on the etiology, pathogenesis, or treatment of endometriosis (EM). The discovery of disease‐associated plasma proteins with causal genetic evidence provides an opportunity to identify new EM biomarkers and therapeutic targets. Methods Protein quantitative trait loci (pQTLs) were derived from plasma proteomic associations in the UK Biobank Pharma Proteomics Project (UKB‐PPP). Genetic associations with EM were obtained from the FinnGen cohort. The asso...

Articles
Zheng J, Yao YL, Chen XZ, Fu LJ, Chi YG, Zhong ZH, Ding YB•
PubMed

Shared Genetic Architecture and Pleiotropic Loci Linking Endometriosis and Inflammatory Bowel Disease: An Integrative GWAS, Colocalization, and Mendelian Randomization Study.

Background Endometriosis (EMS) and inflammatory bowel disease (IBD) are both chronic inflammatory disorders with overlapping clinical features, suggesting a potentially shared etiology. Although epidemiological studies have reported an association between the two conditions, the genetic basis of this relationship remains poorly understood. This study is aimed at characterizing the shared genetic architecture of EMS and IBD, identify pleiotropic loci implicated in both conditions, and explore th...

Articles
Cui X, Wang J, Chen J, Wu H, Liu J, Fang Y, Wan G•
PubMed

Diagnostic Accuracy of the Kissing Ovaries Sign on Transvaginal Ultrasound for Prediction of Bowel Endometriosis in Women with Surgically Confirmed Endometriosis.

Background: Endometriosis is a common gynecological disorder. Non-invasive imaging markers that predict disease severity and bowel involvement are clinically valuable. The purpose of the current study was to evaluate the diagnostic performance of the kissing ovaries (KO) sign on transvaginal ultrasound for predicting bowel endometriosis and advanced disease. Methods: This retrospective diagnostic accuracy study included 252 women with surgically and histopathologically confirmed endometriosis...

Articles
Ahmadbeigi M, Padmehr R, Shadjoo K, Mohammadipour S, Mozzahab A, Gorgin A, Kargar R•
PubMed

Lived Experiences of Endometriosis-Related Pain and Perceptions of a Blended Digital CBT Intervention: A Mixed-Methods Study.

Background Endometriosis affects approximately 10% of women of reproductive age and is associated with reduced health and quality of life yet remains poorly understood and undertreated. The Digital behAvioural HeaLth treatment for chronIc pAin (DAHLIA) aims to enhance behavioural self‐management and resilience to pain through six self‐guided digital modules and regular therapist contact. This study aimed to explore women’s lived experiences of endometriosis‐related pain and their perceptions of...

Articles
Petersson S, Engman L, Carlsson E, Taygar A, Bartels SL, Wicksell RK•
PubMed

An Insight on Flavonoids and Flavonoidsincorporated Nano-formulations in the Management of Diabetes Mellitus.

Diabetes mellitus is a worldwide health challenge and imposes a considerable strain on healthcare systems. By 2035, it is anticipated that around 592 million adults will be impacted by diabetes as a result of causes like aging, rapid population expansion, urbanization, obesity, lifestyle modifications, and heightened intake of calorie-dense, fatty, and fast meals. Despite the availability of several pharmaceutical therapies, they often come with higher expenses and adverse side effects, making t...

Articles
Patel M, Shah P, Singh S, Prajapati BG•
PubMed

Determination, Validation, and Development of Prediction Scores Related to Hypoglycemia Risk Factors Among Ambulatory Type 2 Diabetes Mellitus Patients in Bali, Indonesia.

Introduction Hypoglycemia is a complication that can disrupt the continuity of therapy for Type 2 Diabetes Mellitus (T2DM) patients. Therefore, ambulatory T2DM patients need supportive treatment to ensure the safety of their medication. Currently, health workers lack a standardized reference for assessing the risk of hypoglycemia in these patients. Therefore, this study aimed to determine, validate, and develop a prediction score of risk factors influencing hypoglycemia in T2DM patients. Metho...

Articles
Jaya MKA, Rahmawati F, Yasin NM, Ikawati Z•
PubMed

Beyond Traditional Silos: An Integrated Framework Leveraging Novel Pathways for Reducing Cardio-renal Risk in Type 2 Diabetes.

Diabetes mellitus is a major risk factor for chronic kidney disease (CKD) and accelerates kidney function decline, leading to end-stage renal disease. In addition, patients with CKD are at elevated risk of developing cardiovascular disease with its manifestations as coronary artery disease, heart failure, arrhythmias, and sudden cardiac death through the cardiorenal connection. An online regional and international expert panel of cardiologists, nephrologists, and diabetologists convened in Novem...

Articles
Sabbour HM, Hassanein M, Farghaly M, Aljubori HMMS, Attallah NM, Al Rukhaimi M, Al-Ashkar M•
PubMed

The Application of Omics Technologies in Type II Diabetes Mellitus Research.

Diabetes mellitus represents a spectrum of chronic metabolic disorders characterized by elevated blood glucose levels (hyperglycemia), largely due to insulin deficiency or resistance. Type 2 diabetes mellitus (T2DM) is the most prevalent form, accounting for over 90% of diabetes cases globally. Its rising prevalence is a global concern, with projections indicating 783 million cases by 2045. T2DM leads to severe complications, including macrovascular diseases like cardiovascular events and microv...

Articles
Al Sultan A, Rattray Z, Rattray NJW•
PubMed

Targeting the Gut Microbiota in the Treatment of Type 2 Diabetes: Dietary Interventions, Microbial Preparations, and Fecal Transplantation.

Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disease worldwide, characterized by hyperglycemia and insulin resistance (IR). Its escalating global prevalence and the associated morbidity and mortality render it a major public health concern. Conventional glucose-lowering therapies frequently entail adverse effects, hypoglycaemia risk, and fail to arrest disease progression. Emerging evidence positions the gut microbiota as a central regulator of glucose homeostasis and insulin...

Articles
Ding L, Xi Z, Zou Y, Li S, Chen D, Liu Y, Zhao J•
PubMed

Potential Involvement of Fructosylated Human Insulin and Serological Evidence in Subclinical Autoimmune Activity in Type 2 Diabetes Mellitus.

Introduction Type 2 Diabetes Mellitus (T2DM) involves chronic inflammation and recurrent hyperglycemia, often linked to excessive fructose intake. Some patients develop autoantibodies, indicating immune dysfunction. Fructose promotes protein glycation and the formation of Advanced Glycation End-products (AGEs), which may expose novel epitopes recognized as foreign. This study examined the antigenicity of fructosylated human insulin and its impact on lymphocytes in diabetic patients. Methods F...

Articles
Raza A, Habib S, Noor S, Ahmad R, Chandni M, Moinuddin, Mahmood R, Rahaman PF, Ahmad A•