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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 1,969–1,980 of 2,098 articles

PubMed

Reported Prevalence and Associated Factors of PTSD and Posttraumatic Stress Symptoms Among Individuals With Diabetes: A Scoping Review.

Background Posttraumatic stress disorder (PTSD) and posttraumatic stress symptoms (PTSS) may occur among individuals with diabetes, but reported estimates and associated factors vary considerably across studies. This scoping review is aimed at mapping the reported prevalence of PTSD/PTSS and factors associated with these outcomes among individuals with diabetes. Methods A scoping review was conducted in accordance with the PRISMA‐ScR guidelines. Web of Science, PubMed, Embase, Cochrane Librar...

Articles
Yuanping Z, Ruiqing C, Xiong K, Yuanyuan J•
PubMed

Electroacupuncture May Alleviate Depression and Exerts Anti-Inflammatory Effects Through IDO1 Modulation of the Kynurenine Pathway.

Background Depression is one of the most common mental health conditions worldwide. Numerous studies have identified various factors associated with the onset of depression. Among these factors, inflammation is a key contributor. During the inflammatory process, pro‐inflammatory cytokines activate indole‐2,3‐dioxygenase (IDO), which converts tryptophan (TRP) to kynurenine (KYN) via the KYN pathway (KP). This increases the production of neurotoxic byproducts, thereby exacerbating depressive symp...

Articles
Chen B, Wu X, Ying X, Zhang J, Jiang S, Di Z, Chen Y, Huang Y, Chang H, Ma R, Guo Q•
PubMed

Nonlinear Relationship of Weight-Adjusted Waist Index With Self-Reported Trouble Sleeping and the Mediating Role of Depression.

Purpose The weight‐adjusted waist index (WWI) is a novel measure for obesity that appears to outperform body mass index (BMI) and waist circumference (WC) in assessing lean and fat mass. Our aim was to explore the possible link between WWI and trouble sleeping. Methods This cross‐sectional study included 30,999 adults who participated in the National Health and Nutrition Examination Survey (NHANES) database. The WWI was calculated as WC (cm) divided by the square root of weight (kg). Trouble...

Articles
Song Y, Wang Z, Shao X, Zhong S•
PubMed

Mortality Trends in Patients Aged 25 and Older With Comorbid COPD and Diabetes Mellitus in the United States: A CDC WONDER Database Study From 2000 to 2023.

Introduction Diabetes mellitus (DM) and chronic obstructive pulmonary disease (COPD) are among the leading chronic diseases that significantly impact global morbidity and mortality. Growing evidence indicates a bidirectional interplay between metabolic and pulmonary dysfunction. This study aims to identify the demographic and regional trends of DM and COPD‐related mortality in the United States from 2000 to 2023. Methodology DM‐ and COPD‐related deaths in the United States from 2000 to 2023 w...

Articles
Ahmed M, Fatima S, Shafiq SB, Mansoor KT, Aqsa F, Naveed MA, Ali A, Sandhyavenu H, Qureshi B, Neppala S•
PubMed

Prevalence of Cardiovascular Diseases in COPD-OSA Overlap Syndrome Versus COPD Alone: A Systematic Review.

Background Chronic obstructive pulmonary disease (COPD) is frequently associated with cardiovascular comorbidities. Obstructive sleep apnea (OSA) may coexist with COPD, forming the so‐called overlap syndrome (OS), and may further increase cardiovascular risk through intermittent hypoxia, systemic inflammation, and sympathetic activation. This systematic review is aimed at synthesizing and comparing the burden of cardiovascular comorbidities in patients with COPD and coexisting OSA versus those...

Articles
Oprea ȘF, Dumitrache-Rujinski Ș, Diaconu CC•
PubMed

Adjunctive Short-Wave Diathermy to High-Frequency Chest Wall Oscillation for Acute Exacerbation of COPD: A Randomized Controlled Trial.

Objective This study aimed to evaluate the efficacy and safety of combining short‐wave diathermy (SWD) with high‐frequency chest wall oscillation (HFCWO) compared with HFCWO alone and routine treatment in patients hospitalized for acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods This single‐center, parallel‐group randomized controlled trial enrolled 89 patients with AECOPD admitted to Yongkang First People’s Hospital between March 2024 and March 2025. Participants...

Articles
Li Q, Sun J, Ying L, Ying Z•
PubMed

The Role of Melatonin in Smoking Cessation and COPD Management: A Randomized Controlled Trial.

Background Chronic obstructive pulmonary disease (COPD) is a leading global health concern, characterized by persistent airflow obstruction and a significant burden on quality of life. Smoking cessation is critical for COPD management, but nicotine addiction poses challenges. Emerging evidence suggests that melatonin may aid in addiction management, though its efficacy in COPD remains underexplored. Methods This randomized, triple‐blind, controlled clinical trial evaluated the impact of melat...

Articles
Gholinataj Jelodar M, Haddad N, Hoseinzadeh F, Mirzaei S, Sahebnasagh A, Ramezani V, Mohammadi MH, Saghafi F•
PubMed

Critical Errors in Inhaler Technique Among Patients With Asthma and COPD: A Cross-Sectional Study in a Real-World Setting.

Background The correct use of inhalation devices is essential for achieving adequate control of asthma and COPD; however, critical errors in inhalation technique are frequent and substantially reduce treatment effectiveness. This study’s objective was to evaluate the prevalence of inadequate inhalation technique among patients with asthma and COPD and to identify the most common critical errors and the factors associated with incorrect use. Methods This cross‐sectional observational study inc...

Articles
Damasceno IHM, Oliveira RJF, Neves SJF, Martins RR, Diniz RDS•
PubMed

Neutrophil to High-Density Lipoprotein Cholesterol Ratio and All-Cause Mortality Among Asthmatic Individuals: A Cohort Study.

Background At present, there is no epidemiological study available to confirm the efficacy of neutrophil to high‐density lipoprotein cholesterol ratio (NHR) in assessing the prognosis of the asthma population. This study aims to investigate the value of NHR in assessing the prognosis of asthma patients by utilizing data from National Health and Nutrition Examination Survey (NHANES) and constructing the predictive models. Methods This study used Cox regression models, cumulative risk curves, a...

Articles
Li D, Luo C, Xia J•
PubMed

Linderae Radix Attenuates Hyperlipidemia by Regulating Reverse Cholesterol Transport through the miR-33-PPARα/LXRα Axis.

Introduction It has been reported that miR-33 could down-regulate the key protein expression of reverse cholesterol transport (RCT) to clear excess cholesterol. Our previous studies reported that Linderae Radix (Wuyao in Chinese, WY) has a strong anti-hyperlipidemia effect by regulating RCT, but whether the regulation of WY on RCT is related to miR-33 remains unclear. Methods In in vivo research, mice were randomly divided into five groups. miR-33 agomir was administered to hyperlipidemic (HL...

Articles
Ye H, Lai W, Lei S, Zhang J, Li K, Wang Z, Zheng X, Yang X, Lou Z•
PubMed

Circulating Levels of Remnant Cholesterol as Potential Biomarkers for Predicting Gestational Diabetes: A Systematic Review.

Objectives Gestational diabetes mellitus (GDM) is a common pregnancy complication with serious consequences for both mother and child. Current diagnostic methods are invasive and limited. The present study was conducted to evaluate circulating remnant cholesterol (RC) as a potential predictive and diagnostic biomarker for GDM. Methods The present study was conducted following PRISMA guidelines. Databases including Scopus, PubMed, Web of Science (WoS), Embase, ProQuest, Cochrane, and Google Sc...

Articles
Abdi F, Rahnemaei FA, Khosravani F, Sadri F, Mohammadi Y•
PubMed

Mechanisms, Mediators, and Pharmacological Approaches Targeting Brain Cholesterol Transport in Alzheimer's Disease.

Cholesterol transport within the brain represents a highly regulated process essential for maintaining neuronal function and central nervous system (CNS) homeostasis. Unlike peripheral tissues, the brain relies on in situ cholesterol synthesis, primarily by astrocytes and other glial cells, which supply neurons via high-density lipoprotein (HDL)-like particles, identified in the human cerebrospinal fluid (CSF). The major component of HDL-like lipoproteins is the apolipoprotein E (ApoE), whose E4...

Articles
Ugolotti M, Papotti B, Trentini A, Mola G, Cervellati C, Adorni MP, Zimetti F•