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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 241–252 of 2,098 articles

PubMed

Correlating Laryngoscopic and Clinical Findings With Airway Intervention in Angioedema.

ABSTRACT Objective(s) To evaluate whether specific presenting symptoms and laryngoscopic subsite involvement in aerodigestive angioedema predict clinical severity, defined by airway intervention, hospital admission, and length of stay (LOS). A secondary objective was to assess the performance of a reduced symptom‐based model for predicting intubation. Methods A retrospective cohort study was performed of adult patients presenting with aerodigestive angioedema at a single tertiary academic me...

Articles
Thornton N, Webb K, Bowman CN, Kwak MW, Ali N, Stepp R, York A, Daniero J•
PubMed

Systemic Sarcoidosis After Polycaprolactone Fillers Successfully Treated with Upadacitinib.

Dermal fillers are widely used in aesthetic medicine but may occasionally induce granulomatous reactions. We describe a case of systemic sarcoidosis developing after polycaprolactone filler injections, successfully treated with upadacitinib. CASE PRESENTATION A 56-year-old woman presented with progressive subcutaneous nodules in the nasolabial folds, chin and jawline that appeared 2 years after aesthetic filler injections with polycaprolactone (Ellansé®; polycaprolactone plus carboxymethylcell...

Articles
Behaghel C, Pothen L, Gérard T, Marot L, Baeck M, De Greef A•
PubMed

Hepatic Sarcoidosis as a Rare Cause of Secondary Hemophagocytic Lymphohistiocytosis.

ABSTRACT Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome often triggered by an underlying disease process. Macrophage activation syndrome (MAS) is a secondary HLH phenotype associated with autoimmune disease. A 72-year-old man presented with fever, pancytopenia, hyperferritinemia, splenomegaly, and acute liver injury. Bone marrow biopsy demonstrated hemophagocytosis, supporting HLH. Despite corticosteroid therapy, progressive liver injury prompted liver...

Articles
Shariff H, Nair S, Patel A, Martinez Mencia A, Jiang W, Qualtieri J, Binder A, Mendoza F, Sass DA•
PubMed

Concurrent erythema multiforme and psoriasiform eruption during enfortumab vedotin plus pembrolizumab therapy for advanced urothelial carcinoma.

ABSTRACT Enfortumab vedotin (EV) plus pembrolizumab is an effective first-line treatment for advanced urothelial carcinoma, but clinically significant cutaneous adverse events may require treatment interruption or discontinuation. We report a 74-year-old man with metastatic upper-tract urothelial carcinoma who achieved a complete metabolic and radiologic response after three cycles of EV plus pembrolizumab. After six cycles and before cycle 7, he developed painful plantar lesions that progresse...

Articles
Di Trolio R, Di Lorenzo G•
PubMed

Decoding Immune Dysregulation in Childhood Idiopathic Nephrotic Syndrome: Insights From Lymphocyte Subsets and Urinary Cytokine Analysis.

Background Idiopathic nephrotic syndrome (INS) is a primary kidney disease of childhood involving podocytes where immune dysregulation is thought to play a major role in pathogenesis. The aim of the study was to evaluate peripheral lymphocyte subsets and urinary cytokines in children with INS to understand the immune mechanisms and their association with steroid responsiveness. Methods This was a prospective longitudinal observational study of children with INS, conducted at a tertiary care h...

Articles
Anju Ashok AK, Saharia GK, Satapathy AK, Mangaraj M•
PubMed

Pathogen-specific positron emission tomography for Enterobacterales bone infection.

Aims Gram-negative bone infections involving Enterobacterales group of bacteria pose a growing concern, especially for orthopaedic surgeries and diabetic ulcers. Current imaging methods either identify morphological changes by CT and MRI, or inflammation, using white blood cell scans or 2-deoxy-2-[18F]fluoro-d-glucose ([18F]-FDG) positron emission tomography (PET). While valuable, these are not specific, resulting in delayed diagnoses. PET/CT using 2-deoxy-2-[18F]fluoro-d-sorbitol ([18F]-FDS) i...

Articles
Gordon O, Napiorkowski A, Flavahan K, De Jesus P, Dikeman DA, Kronenberg A, Archer NK, Jain SK•
PubMed

Recurrent oesophageal strictures in bullous systemic lupus erythematosus: a case report.

Dear Editor, Bullous systemic lupus erythematosus (BSLE) represents a rare subset of systemic lupus erythematosus (SLE), affecting fewer than 1% of patients. It is characterized by acute-onset vesiculobullous eruptions with subepidermal blistering, linear deposition of immunoglobulin G and complement at the basement membrane zone (BMZ) [1, 2]. Autoantibodies to type VII collagen contribute to dermal–epidermal separation [2, 3]. We report recurrent oesophageal strictures in a patient with refract...

Articles
Moniati F, Reynolds JA•
PubMed

Long-Term Follow-up of Azathioprine-Induced Portosinusoidal Vascular Disease in a Patient With Crohn's Disease.

ABSTRACT Azathioprine is widely used to treat inflammatory bowel disease, organ transplantation, and autoimmune disorders. Hepatotoxicity is a rare but serious complication. We report a 48-year-old man with ileocolonic Crohn’s disease who developed azathioprine-induced portosinusoidal vascular disease (PSVD) after 15 years of treatment. Diagnosis was suspected due to persistent cytopenia (leukopenia and thrombocytopenia) and when transabdominal ultrasonography and upper gastrointestinal endosco...

Articles
Azizi F, Ouldgougam R, Aouameur Y, Bourezak SES, Gasri M, Amir ZC, Boudjella MEA•
PubMed

Prevalence of Contact Sensitization in Patients with Atopic Dermatitis: A Retrospective Study from China.

The prevalence of contact sensitization in atopic dermatitis (AD) has been controversial and remains poorly studied in the Chinese population. This retrospective study aimed to assess the prevalence and differences in contact sensitization between AD and non-AD patients undergoing patch testing in China. We analysed clinical records of 3,487 patients who underwent patch testing from 2018 to 2023, including 146 AD patients and 3,341 non-AD patients. Results demonstrated that contact sensitization...

Articles
Wang A, Ye C, Fei C, Li Y, Ma Y, Cao T, Wu Y, Cheng Y, Hao F, Zou Y•
PubMed

Vitiligo Following Dupilumab Therapy for Moderate-to-Severe Atopic Dermatitis: A Case Report with Insight into Type 1/Type 2 Immune Imbalance.

Abstract Dupilumab, a biologic agent, has been widely utilized for its remarkable therapeutic efficacy in treating moderate-to-severe atopic dermatitis (AD). This report presents a case of a 72-year-old male with a 2-year history of AD who experienced complete resolution of AD symptoms after dupilumab treatment. However, hypopigmented macules, consistent with vitiligo, were observed diffusely on the scalp, preauricular region, postauricular region, lateral cervical region, posterolateral cervic...

Articles
Gong X, Chen J, Jiang J, Mei Q•
PubMed

Chitosan functionalized selenium nanoconjugates of Mucuna pruriens as a nanotherapeutic approach for Parkinson's disease.

Nature’s mother holds many untapped treasures of phytoconstituents that can cure and exhibit unexpected therapeutic activity against several diseases. Seeds of velvet beans, popularly known as Mucuna pruriens (MP), are the richest source of Levodopa (L-DOPA). L-DOPA is the precursor for dopamine, a key neurotransmitter deficient in the brain of patients suffering from Parkinson’s disease (PD). The peripheral degradation of L-DOPA before crossing the blood-brain barrier (BBB) is the greatest chal...

Articles
Sahoo SS, Modak S, Sahu PK, Behera A, Ranch KM, Swain RP•
PubMed

Treat-to-target weight management in fibromyalgia: a preliminary estimate of clinically meaningful weight loss.

Dear Editor, Clinicians routinely advise patients with fibromyalgia and obesity to lose weight, expecting symptomatic benefit. Yet this recommendation remains nonspecific, as we lack a clear understanding of how much weight loss is required for a clinically relevant benefit. Rheumatology has embraced a treat-to-target philosophy, defining quantitative goals that guide management in rheumatoid and psoriatic arthritis and increasingly framing obesity itself as a modifiable target with defined thre...

Articles
Ciaffi J, Ablin JN, Aloush V, Caporali R, Ursini F•