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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 253–264 of 2,098 articles

PubMed

Motivation in adolescents and caretakers undergoing a weight management program - longitudinal data from the cluster-randomized, motivation-focused STARKIDS trial.

Background Motivation towards behavior change is an important determinant of long-term weight management. Previous research demonstrates that children’s and adolescents’ motivation can be increased through participation in weight management programs. However, little is known about motivational changes in caretakers of children and adolescents with overweight and obesity despite their recognized role as “agents of change” in pediatric weight management. The study aims to compare motivational cha...

Articles
Herschbach A, Junne F, Erschens R, Ehehalt S, Jacoby J, Martus P, Mack I, Weiland A, Krauß I, Greule C, Sudeck G, Zurstiege G, Wels A, Adam SH, Hoell A, Bethge W, Ums M, Sammet T, Reyer M, Schliesing O, Zipfel S, Gawrilow C, Giel KE, Ziser K•
PubMed

The Gut Microbiota-Associated Metabolite Network in Ischemic Stroke: From Pathophysiological Imbalance to Potential Precision Intervention Strategies.

Abstract Ischemic stroke (IS) remains a leading cause of death and long-term neurological disability worldwide, and current treatment options are constrained by narrow therapeutic windows and limited neuroprotective efficacy. Accumulating evidence implicates the microbiota-gut-brain axis (MGBA) in the development and progression of IS. Following cerebral ischemia, bidirectional communication between the brain and gut is disrupted, resulting in gut microbial dysbiosis, impaired intestinal barrie...

Articles
Jia X, Zheng X, Tu R, Lyu P, Chen X, Zhang M, Bu N, Wang Y, Bai Y, Wang S•
PubMed

Burden and clinical characteristics of respiratory syncytial virus infection in older adults in the outpatient setting in Germany: a prospective multiseason study.

Background Respiratory syncytial virus (RSV) is a leading cause of acute respiratory infections (ARI), yet evidence from outpatient settings, particularly among older adults, remains limited. Methods BUCOSS was a prospective observational study conducted across three consecutive respiratory seasons (2022–2025) in patients aged ≥ 60 years with ARI, recruited from 29 primary care and office-based pulmonology practices. RSV and other respiratory pathogens were identified via multiplex polymerase...

Articles
Hinze CA, Barten-Neiner G, Eberhardt F, Reeves R, Marijic P, Stierl M, Martens B, Wyen C, Landgraf I, Freye M, Knaupp T, Ammenwerth W, Schmidt P, Panning M, Diel R, Rohde G•
PubMed

Scoping Review of Acupuncture for Migraine: Current Evidence and Research Gaps.

Background Migraine is a disabling neurological disorder that significantly impairs quality of life and imposes a substantial socioeconomic burden. While acupuncture has shown clinical benefits for migraine management, the scope and methodological quality of the existing evidence remain unclear. This scoping review aimed to map the current landscape of clinical research on acupuncture for migraine, characterize the evidence base, identify research gaps, and inform future research priorities. M...

Articles
Wu Y, Ji Y, Wu Y, Li W, Zhang J, Yao C, Li Z, Xiao B•
PubMed

The Paradox of Vulnerability: An Interpretative Phenomenological Analysis of Mental Health Among Academicians in Malaysian Public Universities.

Purpose Academicians in higher education are positioned as authoritative knowledge bearers, yet their own mental health remains comparatively unexamined by research, which has instead focused predominantly on students. This creates a conceptual and literature blind spot around a population that experiences personal distress despite its revered status. The purpose of this study is therefore to examine how academicians at Malaysian public universities experience and make sense of their mental hea...

Articles
S Senathirajah ARB, Sivagurunathan R, Haque R, Qazi S, Qayyum S, Sun J, Ng PK•
PubMed

Health Information Literacy Moderates the Associations of Perceived Social Support with Insomnia and Infertility Psychological Distress in Women Undergoing Assisted Reproductive Technology: A Cross-Sectional Study.

Purpose Psychological distress is common among women undergoing assisted reproductive technology (ART). Perceived social support, insomnia, and health information literacy may be interrelated with psychological distress during fertility treatment, but their conditional relationships remain insufficiently understood. This study examined the indirect association between perceived social support and infertility psychological distress through insomnia and whether health information literacy moderat...

Articles
Jiang L, Wu M, Yao J, Yang L, Yang J, Yuan M, Zhang K, Zhang Q, Zhao M, Zeng T•
PubMed

Statistical Reporting Consistency and Interpretation of Mediation Effects in Intergenerational Support and Late-Life Depression: A Comment on Hu et al [Letter].

Dear editor I read with interest the cross-sectional study by Hu et al, which examined intergenerational support, social networks, attitudes toward aging, and depressive symptoms among 1157 older adults in China. The integration of familial and social resources is thus valuable. However, several inconsistencies in the published descriptive and mediation results warrant clarification.1 First, the published total means do not equal the sums of their corresponding component means. The intergenera...

Articles
Menhas R•
PubMed

Remnant Cholesterol Inflammatory Index and its Association With Cardiometabolic Multimorbidity in Middle-Aged and Advanced-Aged Individuals: Evidence From the China Health and Retirement Longitudinal Study.

Background The association between remnant cholesterol inflammatory index (RCII) and cardiometabolic multimorbidity (CMM) remains unclear. RCII is defined as: {Total Cholesterol − (High-Density Lipoprotein Cholesterol + Low-Density Lipoprotein Cholesterol)] × High-Sensitivity C-Reactive Protein/10}. This study examined the association between baseline RCII and CMM among middle-aged and older adults in China. Material/Methods This study analyzed data from the China Health and Retirement Longit...

Articles
Wang Y, Dong Q, Wang W, Tang S, Yu N, Wang Y, Zou C•
PubMed

A Rare Case of Aleukemic B-Cell Acute Lymphoblastic Leukemia Presenting as Rapidly Progressive Severe Low Back Pain in an Adolescent With a History of Anxiety and Depression.

Introduction Musculoskeletal complaints are a frequent cause of pediatric emergency visits. While adolescent back pain is typically benign, it can occasionally signal underlying malignancy. Distinguishing organic pathology from functional disorders is particularly challenging in patients with pre‐existing psychiatric comorbidities, leading to potential diagnostic delays. Case Presentation We report a 17‐year‐old female with a history of anxiety and depression presenting with two weeks of seve...

Articles
Huang T, Meng L, Zheng L, Han X, Ansa-Addo E, Hong F•
PubMed

Identifying biomarkers for methotrexate efficacy in rheumatoid arthritis: a machine learning approach to whole-blood transcriptomic analysis.

Abstract Objectives Methotrexate (MTX) is the first-line treatment for rheumatoid arthritis (RA), yet inadequate response is reported in 30–40% of patients. Predicting MTX response early could enable more personalized and effective treatment. This study aimed to identify biomarkers predictive of MTX response at 6 months through whole-blood transcriptomic signatures using machine learning. Methods RNA sequencing data were generated in whole-blood samples taken from 100 MTX-naive RA patients a...

Articles
Yap CF, Nair N, Verstappen SMM, Hyrich K, Barturen G, Rivas-Torrubia M, Gut M, Gut I, Alarcón Riquelme ME, Barton A, Plant D, RAMS Co-Investigators•
PubMed

Rheumatoid Arthritis and Sleep Disturbances: A Narrative Review of Bidirectional Mechanisms.

Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease in which sleep disturbances are common and closely linked to pain, fatigue, mood symptoms, physical dysfunction, and disease activity. This narrative review synthesizes clinical and mechanistic evidence for a bidirectional relationship between RA and impaired sleep while distinguishing diagnosed sleep disorders from transdiagnostic sleep symptoms. RA-related inflammation, pain, stiffness, and psychological comorbidity may impai...

Articles
Fan X, Zhao F, Cheng Y, Zhang C, Zhu X, Shen Z, He D•
PubMed

Anxiety and Depression in Glaucoma: A Narrative Review of Bidirectional Associations, Causal Evidence, and Clinical Implications.

Background Anxiety and depressive symptoms are common neuropsychiatric comorbidities in glaucoma, but the direction and causal meaning of these associations remain uncertain. Objective To evaluate evidence in both directions by assessing whether glaucoma contributes to anxiety and depression and whether anxiety or depression influences glaucoma-related outcomes or progression. Methods We conducted a structured narrative review of PubMed, Web of Science Core Collection, CNKI, Wanfang Data, a...

Articles
Liu R, Geng X, Han W, Zhao Y•