Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Background Evidence on the uptake and determinants of liver cancer screening in Southwest China remains limited. This study aimed to assess the participation rate, influencing factors, and screening outcomes among high-risk individuals in a population-based liver cancer screening program. Methods A community-based screening program was conducted across 18 districts or counties in Chongqing, China, from October 2013 to October 2022. High-risk individuals identified through a risk assessment sy...
Liver Cancer
Li B, Yu Z, Zhang Y, Li Q, Liu X, Guo Q, Zhou H, Du J, He M•
Background Postoperative pulmonary complications (PPCs) are common after hepatectomy and are associated with delayed recovery, prolonged hospitalization, and increased healthcare burden in patients with primary liver cancer (PLC). Existing PPC risk assessment approaches are mainly derived from general surgical populations and may not adequately incorporate hepatectomy-specific perioperative factors, including surgical complexity and intraoperative characteristics. This study aimed to develop an...
Endometriosis (EMS) is a chronic inflammatory disorder marked by ectopic endometrial lesions that commonly cause pain and infertility. Existing surgical and hormonal therapies are limited by adverse effects and high recurrence rates, while nanozyme-based approaches offer opportunities to develop alternative therapeutic strategies. Here, we developed bio-dissociable platinum quantum dot clusters (PtQDC) as nanozymes for nonhormonal EMS therapy. PtQDC undergoes gradual dissociation in lesion tissu...
Endometriosis
Cao C, Ding J, Hao H, Jiao Y, Cao Y, Fu Y, Cui X, Gao D, Gao Y, Wang Y, Yu C, Wang T, Liu Y•
The molecular mechanism by which hypoxia-inducible factor 1-alpha (HIF-1α) regulates asthma pathogenesis through modulation of neutrophil extracellular trap (NET) formation remains poorly defined. Given that NETs act as core drivers of allergic asthma pathology by amplifying airway inflammation and inducing airway epithelial ferroptosis, this study aimed to elucidate the regulatory axis involving airway epithelial cell-derived exosomal miR-146a-3p. We proposed that exosomal miR-146a-3p directly...
Asthma
Yang J, Li Y, Li Z, Liu M, Xiang Y, Xu F, Zhang Y, Li G, Chai J, Yan G, Wang C•
Background Connective tissue disease-associated pulmonary hypertension (CTD-PH) is a serious complication, but evidence on early oral treatment intensification in patients followed primarily by echocardiography is limited. We evaluated outcomes associated with initial selexipag-containing oral triple therapy vs. dual therapy in echocardiography-defined CTD-PH. Methods This single-center retrospective cohort included consecutive adults who initiated PH-targeted therapy between April 2020 and J...
Pulmonary Hypertension
Shen X, Chen Q, Ren M, Wang L, Wu J, Cao J, Yin Y, Ren T, Zhou X, Cheng T, Wang M•
by Matt Baker, Physicians Office Resource From the first abnormal glucose result to long-term risk reduction, the physician’s most valuable tool may be a workable plan and a continuing relationship.
Infectious mononucleosis caused by Epstein-Barr virus (EBV) commonly presents with pharyngitis, lymphadenopathy, and fever. Cutaneous eruptions may occur, particularly following antibiotic exposure. We report a case of a man in his late 20s who developed a widespread maculopapular rash following sequential exposure to multiple antibiotics in the setting of acute EBV infection. The rash progressed to involve the palms and soles, raising concern for secondary syphilis and a possible drug hypersens...
Inflammatory bowel disease(IBD) is commonly diagnosed during the reproductive years, making sexuality, fertility, pregnancy, and lactation central to long-term care. Misconceptions about heritability, fertility, and medication safety contribute to voluntary childlessness and discontinuation of effective therapy during pregnancy. Accumulating evidence indicates that disease activity, rather than IBD itself or most maintenance therapies, is the major determinant of adverse maternal and fetal outco...
Lactation
Song EM, Yoon J, Kim SE, Kim DH, Yang YJ, Shin SY, Kim JE, Bae JH, Hong SM, Kang SB, Kim ES, Kim SJ, Lee J, Na SY, Park SJ, Park SH, Yun H, Kim TH, Lee YJ, Kim MH, Choi M, Moon W, Jung SA, Guidelines Committee of the Korean Association for the Study of Intestinal Diseases (KASID)•
Purpose Spirometry is the standard for assessing airflow obstruction in COPD, but low-burden screening tools may support primary care in identifying patients needing referral, potentially enabling earlier diagnosis and timely disease management. A novel, easy-to-use device (AMES BV, the Netherlands) estimates obstruction from nasal pressure variation during tidal breathing and may support referral decisions. This study aimed to assess the ability of nasal pressure analysis to identify airflow o...
ABSTRACT Objectives The study aimed to assess the prevalence of sarcopenia and sarcopenic obesity among community‐dwelling postmenopausal women. It also examined predictors of these conditions and their association with bone fragility. Methods The cross‐sectional study included 300 community‐dwelling ambulant postmenopausal women aged 50 years or older recruited over 2 years. All participants underwent assessment of body mass index, bone mineral density, and body composition by dual‐energy X...
Obesity
Rajan R, Cherian K, Paul T, Asha HS, Jose A, Rebekah G, Thomas N, Kapoor N•
Objectives: This study aimed to identify specific microbiota associated with diarrhea-predominant irritable bowel syndrome (IBS-D) and to evaluate clinical improvement in IBS-D according to changes in gut microbiota abundance following treatment with Hangeshashinto (HST), an anti-inflammatory Kampo medicine. Methods: This post-hoc retrospective analysis included 20 IBS-D patients from a previous study in whom gut microbiota had been analyzed. Patients were enrolled at two affiliated instituti...
Diarrhea And Irritable Bowel
Yoshida N, Yasuda T, Inagaki Y, Tomita Y, Hirose R, Kobayashi R, Iwai N, Inoue K, Dohi O, Uchiyama K, Takagi T•
Background Gastric syphilis is a rare manifestation of Treponema pallidum infection and an important mimic of gastric malignancy. Because its clinical, endoscopic, and histologic findings are nonspecific, diagnosis requires careful clinicopathologic correlation. Case Presentation A 20-year-old woman presented with recurrent epigastric pain, nausea, and acid reflux. Examination revealed painless oral and nasal mucous patches. Serologic testing was positive for T. pallidum-specific antibody, wi...
Syphilis
Han W, Zhang Q, Ye H, Ma J, Wang C, Maimaiti H, Chen L, Wang Y, Song X•
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