Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
Abstract In a study of oral linezolid among 18 patients with early syphilis, 15 showed adequate serological response by 6 months. Among 6 patients treated with benzathine penicillin G, 5 showed adequate serological response. There were no serious adverse events. Linezolid shows promise for the treatment of early syphilis.
A 23-year-old female presented with urticaria, peri-orbital angioedema, wheeze and cough during intense exercise, with progression slowed by exercise cessation. Additional triggers included passive heating and strong emotion, while low-to-moderate intensity exercise did not provoke symptoms. Symptoms occurred independently of food intake. Past medical history included exercise-induced bronchoconstriction (EIB), eczema and seasonal allergies. Skin-prick and specific IgE testing for food allergens...
The clinical challenge of eradicating bone infection stems from microbial persistence within a distinct skeletal niche that is poorly perfused, hypoxic, mineralised, and highly susceptible to collateral damage. Neutrophils are central arbiters of this process and function as a double-edged sword: they are indispensable for initial pathogen containment, yet can become major drivers of chronic osteolysis, biofilm persistence, and inflammation when their effector programmes turn maladaptive. Recent...
Purpose of the Review Implementation science, a multi-method research area that integrates input from constituents and content experts, has emerged as an important tool in improving implementation of evidence-based practices. This review summarizes three ongoing implementation studies focused on identification of patients with significantly increased risk for atherosclerotic cardiovascular disease (ASCVD) due to genomic risk such as familial hypercholesterolemia (FH) within a single health syst...
Atrazine (ATR), a widely applied herbicide, poses health risks to animals and humans owing to its environmental persistence and bioaccumulation. Kidney is a target organ of ATR, and renal ion disturbance is a major effect of ATR-induced nephrotoxicity. Selenium-enriched yeast (Yeast-Se) is an organic selenium source with high bioavailability and antioxidant properties that protects against chemical-induced organ damage. This study aimed to explore investigate the protective effect of Yeast-Se on...
Purpose To describe short-term clinical and anatomical outcomes associated with oral prednisolone and posterior sub-Tenon triamcinolone acetonide as initial corticosteroid-based treatment strategies in acute ocular Vogt–Koyanagi–Harada Disease (VKH). Methods This retrospective comparative cohort study included 30 treatment-naïve patients (60 eyes) with acute ocular VKH treated at a tertiary referral center between January 2021 and December 2025. Patients were classified using a study-specific...
Background: Adolescent pregnancy remains a significant public health concern, particularly in low- and middle-income countries (LMICs). Although various interventions have been implemented to address this issue, many have failed to achieve positive outcomes due to numerous barriers. Objective: To explore the barriers to implementing adolescent pregnancy prevention interventions in LMICs. Methods: This qualitative exploratory study involved 19 adolescent pregnancy prevention program implementers...
The word “study” is misspelled in the article title. The correct title is: Ultrasound-guided microwave ablation versus conventional surgery for Granulomatous Lobular Mastitis: A two-center retrospective comparative study. The correct citation is: Lin Y, Hong Z, Xie W, Lu A, Wu X, Chen D (2026) Ultrasound-guided microwave ablation versus conventional surgery for Granulomatous Lobular Mastitis: A two-center retrospective comparative study. PLoS One 21(6): e0351776. https://doi.org/10.1371/journal....
Schistosomiasis remains an important but neglected public health problem in Uganda. We estimated its prevalence, microscopy-based species distribution and associated factors among women delivering at Jinja Regional Referral Hospital. A hospital-based analytical cross-sectional study included 392 women from 1 September to 30 December 2025. One stool and one urine specimen per participant were examined microscopically for Schistosoma mansoni and S. haematobium, respectively. Multivariable logistic...
Background: Stroke is a major cause of morbidity and mortality worldwide, with hypertension being its most important modifiable risk factor. Although the association between elevated blood pressure and stroke is well established, the extent to which longitudinal blood pressure patterns influence the timing of stroke remains poorly understood, particularly in low-resource settings. We investigated the association between longitudinal systolic and diastolic blood pressure trajectories and time to...
Background: Low back pain (LBP) is a common musculoskeletal disorder during pregnancy that can affect quality of life. While extensively studied in high-income countries, data from sub-Saharan Africa remain scarce. This study aimed to determine the prevalence, identify associated factors, and assess the impact of LBP among pregnant women in Ouagadougou, Burkina Faso. Methods: A cross-sectional study was conducted from February to May 2024 in 11 primary healthcare centers across five health distr...
Smoking is a well-documented risk factor for chronic diseases, including arthritis. Vaping, often marketed as a safer alternative, has risen sharply, yet its implications for musculoskeletal health remain unclear. We examine the associations of vaping and smoking with arthritis using Double Machine Learning (DML), and present illustrative economic scenarios projecting the potential cost implications of arthritis cases associated with these behaviors. Data from the Behavioral Risk Factor Surveill...
