Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.
The affiliation for the ninth author is incorrect. Rui Wu is not affiliated with #8 but with #7: Department of Infectious Diseases, Hangzhou Xixi Hospital, Hangzhou Sixth People's Hospital, Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Marburg virus disease (MVD), a deadly zoonotic illness in humans, is caused by the Marburg virus (MARV), a single-stranded RNA virus belonging to the Orthomarburgvirus genus of the Filoviridae family. There are currently no approved vaccines or efficient antiviral therapies for MARV, despite high morbidity and fatality rates of the virus, particularly in Africa. Recognizing its epidemic potential and its inclusion on the WHO list of blueprint priority pathogens, an immunoinformatics approach was...
Background Cough variant asthma (CVA) is a prevalent but underdiagnosed subtype of chronic cough, largely due to the limited accessibility of pulmonary function tests in primary care. Objective This study aimed to develop and prospectively validate an interpretable machine learning model using routine laboratory data to facilitate accessible CVA screening. Methods We conducted a multicenter study combining retrospective model development and prospective validation using data from January 20...
Abstract A total of 568 sows (Line 1050, PIC Genetics, Hendersonville, TN) and their litters (PIC 337 × 1050) were used to evaluate the effects of United States grain sorghum compared to corn in lactation diets on sow and litter performance. Sows, in four separate farrowing groups (approximately 142 ± 1 sows per group), were moved into farrowing rooms and blocked by parity on d 112 ± 1 of gestation. Sows were assigned to one of three dietary treatments, consisting of diets with corn, grain sorg...
Chronic pharyngitis is a clinically heterogeneous condition in which persistent throat symptoms, visible mucosal abnormalities, and underlying biological processes do not necessarily coincide. This critical narrative review synthesizes evidence from human chronic pharyngitis, experimental injury models, adjacent upper-airway disorders, and other mucosal systems to examine how epithelial barrier function, innate and adaptive immunity, microbial ecology, sensory signaling, and tissue repair may co...
Objectives This study aimed to compare plasma spermine and spermidine concentrations in patients with primary open-angle glaucoma (POAG), patients with exfoliation glaucoma (EG), and healthy individuals, and to explore their potential association with disease severity. Materials and Methods This prospective case-control study was conducted at a tertiary referral center and included patients with an established diagnosis of POAG or EG for more than two years. The control group consisted of age...
Psoriasis is a chronic, immune-mediated inflammatory dermatosis characterized by a profound dysregulation of immune-epithelial crosstalk. Beyond canonical ATP production, mitochondria function as essential intracellular immunometabolic hubs embedded within the cytokine-driven network of psoriatic lesions. Within this inflammatory niche, keratinocytes and immune cells undergo structural and metabolic adaptations. Aberrant mitochondrial stress byproducts—including mitochondrial reactive oxygen spe...
Pemphigus is a severe autoimmune bullous disease characterized by the production of pathogenic autoantibodies leading to acantholysis. Emerging evidence suggests that microRNA regulate immune responses and may contribute to disease pathogenesis. However, an updated, integrative synthesis linking miRNA expression profiles to their molecular targets remains lacking. This review specifically addresses the expression profiles, target genes, and molecular pathways of miR-338-3p, miR-146a-5p, miR-155-...
Rationale: Antivenom is the key specific treatment for clinically significant snakebite envenoming. Delayed serum sickness-like reactions after antivenom therapy may be overlooked after discharge and can resemble infection or septic shock. Patient concerns: A woman in her early 60s returned approximately 7 days after antivenom therapy with generalized urticarial and purpuric maculopapular rash, pruritus, fever, vomiting, fatigue, dizziness, hypotension, and thrombocytopenia. Diagnoses: The...
Recent studies have confirmed the connection between gut microbiota (GM) and hyperlipidemia. This study used the Mendelian randomization (MR) technique to explore the association between GM and hyperlipidemia. MR was used to examine data derived from a genome-wide association study that combined data from 211 intestinal microbiota and hyperlipidemia. Five statistical tools were used for statistical analyses, including the MR-Egger method, the weighted median method, the inverse variance weighted...
Background Dietary factors have been associated with Crohn’s disease (CD), but evidence regarding the role of combined dietary patterns remains limited. We investigated the associations of individual food consumption and broader dietary patterns with CD. Methods This case–control study included 219 patients with CD and 395 controls. Intake frequency of selected foods was scored on a four-level scale. Based on the combined consumption of foods classified as risk-promoting or protective, partic...
Background Numerous baseline mucosal transcriptomic signatures have been proposed to stratify therapeutic outcomes in ulcerative colitis (UC), but cross-cohort transferability is frequently undermined by platform heterogeneity, endpoint/timepoint differences, and drug-specific biases. The resulting lack of a biologic-agnostic molecular baseline has limited clinical translation and prospective trial design. Methods We integratively re-analyzed endpoint-linked baseline mucosal transcriptomes fr...
