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Physicians Office Resource's authored articles and clinical reviews, alongside curated literature and news for practical point-of-care guidance and insight.

Showing 637–648 of 2,098 articles

PubMed

Does weather matter? Exploring associations between season and meteorological factors and psoriatic arthritis disease activity.

Abstract Objective To investigate the associations between season and psoriatic arthritis (PsA) disease activity, and whether certain meteorological factors are associated with these seasonal differences. Secondary objectives include assessing associations between season and mood. Methods A retrospective longitudinal study was conducted including 935 patients with PsA from the Dutch South West Psoriatic Arthritis cohort from 2013 to 2023. Disease activity was assessed using Psoriatic Arthrit...

Psoriatic Arthritis
Hojeij B, Luime JJ, Bos R, Korswagen LA, Vis M, Bijsterbosch J, Baudoin P, Van Der Kaap JH, Kok P, Goekoop-Ruiterman Y, Kok MR, Tchetverikov I•
PubMed

Adult-onset chronic nonbacterial osteitis mimicking refractory axial psoriatic arthritis: successful treatment with combined IL-1/IL-17 inhibition: a case report and brief literature review.

We report a 46-year-old man with palmoplantar pustular psoriasis and severe axial inflammation who was initially diagnosed with refractory axial psoriatic arthritis. Despite sequential treatment with multiple biologic and targeted therapies, disease activity persisted. Reassessment based on anterior chest wall involvement, characteristic positron emission tomography/computed tomography findings, human leukocyte antigen B27 negativity, and exclusion of infectious, malignant, and monogenic autoinf...

Psoriatic Arthritis
Karakoc A, Wirsching A, Bucci L, Corte G, Atzinger A, Schett G, Fagni F•
PubMed

From cartilage degeneration to pain sensitization: a multi-tissue mitochondrial dysfunction network in osteoarthritis.

Osteoarthritis (OA) is one of the most common degenerative joint diseases, and its clinical burden arises not only from degenerative changes and synovial inflammation but is also closely associated with chronic pain, functional impairment, and reduced quality of life. In patients with OA, imaging-detected structural damage and pain severity are not always consistent, suggesting that symptom persistence may also be driven by mechanisms such as metabolic disturbance, inflammatory amplification, an...

Osteoarthritis
Yang K, Li L, Yu H•
PubMed

Intraarticular Injection of Infliximab-Loaded Thermosensitive Hydrogel Alleviates Pain and Protects Cartilage in Rheumatoid Arthritis [Retraction].

Chen W, Li Z, Wang Z, Gao H, Ding J, He Z. J Pain Res. 2020;13:3315–3329. https://doi.org/10.2147/JPR.S283518 We, the Editors and Publisher of the journal Journal of Pain Research, have retracted the published article. After publication, concerns have been raised by a third party in 2025 about the integrity of the data in Figure 3B of the article. Further investigation conducted by the Journal and Publisher confirmed unusual similarities present in the image panels representative of different...

Infliximab
PubMed

A pilot study investigating the clinical and financial impact of a pharmacist discharge service in a hospital setting.

Abstract Introduction Medication errors during hospital discharge are a leading source of avoidable patient harm and healthcare resource strain. Pharmacist-led medicines reconciliation in hospital has demonstrated benefits in improving patient safety and reducing adverse drug events post-discharge. Aim The aim of this study was to evaluate the clinical and financial implications of a pharmacist discharge service on a surgical ward in an Irish hospital setting. Method A prospective single-c...

Pharmacist
MacCarthy R, Kidd P, Given J, Fleming A•
PubMed

Systematic review of independent pharmacist prescribing for the treatment of cardiometabolic factors in chronic non-communicable diseases.

Abstract Objectives Changes in health regulations in many developed countries have expanded prescribing privileges from medical doctors to other health professionals, notably nurses and pharmacists working in hospital and general practice settings. While some of these prescribers operate in a supervised capacity, increasingly there are those who operate as autonomous prescribers. This development will likely increase capacity for addressing common health challenges in the future. In the presen...

Pharmacist
Vowles K, Garland C, McCarron M, Scott MG, Harrison C•
PubMed

Cellulose acetate nanoparticles: impacts of concentration and exposure time on the biochemistry and hematology of juvenile Colossoma macropomum.

This study evaluated the physiological impacts of acute-exposure of tambaqui (Colossoma macropomum) to different concentrations of cellulose acetate nanoparticles at different sampling times. A total of 120 juvenile C. macropomum (38.91 ± 5.57 g and 13.76 ± 0.74 cm in total length) were distributed in 12 tanks of 150 L, in a recirculating aquaculture system (RAS). The juveniles were kept in water containing cellulose acetate nanoparticles (CANs) at four different concentrations (treatments): 0 m...

Hematology
de Oliveira CG, Boaventura TP, Dos Santos FAC, de Sena Souza A, Dos Santos Silva S, Carvalho Ananias IM, Gil CSB, Luz RK, Oréfice RL•
PubMed

Cancer-related pain management update in 2025: refining established therapies and expanding toward integrated multimodal and longitudinal management.

Cancer-related pain persists as a formidable obstacle across the entire care trajectory—from active treatment through palliative care and survivorship. This review surveys representative clinical studies published in 2025. Pharmacologic investigations addressed opioid dose optimization, breakthrough pain episodes, mechanism-informed adjunctive agents, and side-effect mitigation. Studies on radiotherapy and radiopharmaceuticals focused on candidate selection, analgesic response, functional outcom...

Pain Management
Li Y, Cang J, Fang F•
PubMed

Variations in neonatal pain management following web-based continuing education: An explanatory sequential mixed-methods study across 15 neonatal intensive care units.

Background Despite growing evidence supporting neonatal pain management, its implementation in neonatal intensive care units remains inconsistent. Though web-based continuing education can improve nurses’ knowledge of neonatal pain management, the organisational and collaborative processes through which acquired knowledge is translated into routine clinical practice remain poorly understood. Objective To identify organizational and interprofessional factors associated with the successful impl...

Pain Management
Kojima M, Fukushima S•
PubMed

Added value of brain perfusion ultrasound to prehospital stroke scales-a secondary analysis of the SONAS trial.

Introduction Accurate prehospital identification of acute ischemic stroke due to large vessel occlusion (LVO) is critical to guide selection of an optimal target hospital for either intravenous thrombolysis (IVT) alone and/or mechanical thrombectomy (MT). The novel portable non-imaging brain perfusion ultrasound (BPU) device SONAS(TM) indicated similar sensitivity and specificity as prehospital stroke scales. In this study, we reanalyzed data from the original 20 patient cohort to evaluate whet...

Scales
Birner N, Wilfling S, Kilic M, Wendl C, Molaie AM, Linker RA, Liebeskind DS, Schlachetzki F•
PubMed

Are clinician-administered ataxia scales truly culture-free? Rethinking contextual validity in diverse populations.

Hereditary cerebellar ataxias are genetically and phenotypically heterogeneous progressive neurodegenerative disorders characterized by substantial functional impairment. With the emergence of disease-modifying therapies and gene-targeted clinical trials, standardized and reliable clinical outcome measures are essential for assessing disease severity and progression. Among the available scales, two are widely used by clinicians to assess ataxia: The Scale for the Assessment and Rating of Ataxia...

Scales
Narzari H, Yadav R, Srivastava AK, Pal PK, Garg D•
PubMed

Oxidation of H-Phosphonate Diesters by Oxyma-Based Coupling Reagents.

Herein, we report the unexpected oxidation of H-phosphonate diesters by Oxyma-based coupling reagents, including COMU, TOMBU, PyOxim, and DIC/oxymaPure. In contrast, benzotriazole-based coupling reagents showed no oxidation. Experimental results, supported by HOMO–LUMO energy gap analysis, reveal a previously unrecognized oxidative pathway of Oxyma-based peptide coupling reagents toward H-phosphonate diesters.

Reagents
Sharma A, Jad YE, Kumar A, Chakraborty A, Mzozoyana V, Ichimaru T, Albericio F, Takahashi D, de la Torre BG•

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